Natural Product Reports, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
A personal selection of 32 recent papers is presented covering various aspects current developments in bioorganic chemistry and novel natural products such as asperochone from
Language: Английский
Nachrichten aus der Chemie, Journal Year: 2025, Volume and Issue: 73(3), P. 40 - 70
Published: Feb. 28, 2025
Abstract Highlights von November 2023 bis 2024: die erste Einelektron‐C–C‐σ‐Bindung und Anti‐Bredt‐Verbindung; gesättigte Heterocyclen elektrochemisch funktionalisieren; Ausrichten diskotischer Flüssigkristalle; enantioselektive Wagner‐Meerwein‐Umlagerung reiner Aliphaten; photokatalytisch Furanen zu Pyrrolen; mit Ammoniak primären Arylaminen; Metallschrott recyceln ionischen Flüssigkeiten; terminale Alkene Ni‐Katalysatoren zum (Z)‐ oder (E)‐Alken isomerisieren;neue Fungizide, Medikamente Alkaloide.
Citations
0
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
Synthetic biology has played an important role in the renaissance of natural products research during post-genomics era. The development and integration new tools have transformed workflow product discovery engineering, generating multidisciplinary interest field. In this review, we summarize recent developments biosynthesis from three different aspects. First, advances bioinformatics, experimental, analytical to identify associated with predicted biosynthetic gene clusters (BGCs) will be covered. This followed by extensive review on heterologous expression bacterial, fungal plant organisms. native host-independent paradigm identification, pathway characterization, enzyme is where synthetic most prominent role. Lastly, strategies engineer pathways for structural diversification complexity generation discussed, including assembly-line megasynthase precursor-directed modification, combinatorial biosynthesis.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Dec. 15, 2023
Actinobacteria, the bacterial phylum most renowned for natural product discovery, has been established as a valuable source drug discovery and biotechnology but is underrepresented within accessible genome strain collections. Herein, we introduce Natural Products Discovery Center (NPDC), featuring 122,449 strains assembled over eight decades, genomes of first 8490 NPDC (7142 Actinobacteria), online Portal making both publicly available. A comparative survey RefSeq Actinobacteria highlights taxonomic biosynthetic diversity collection, including three new genera, hundreds species, ~7000 gene cluster families. Selected examples demonstrate how Portal's metadata, genomes, clusters can be leveraged using mining approaches. Our findings underscore ongoing significance in serves an unparalleled resource genomes.
Language: Английский
Citations
7
Natural Product Reports, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 18, 2024
Covering: up to 2024.For many years, the value of complex polyketides lay in their medical properties, including antibiotic and antifungal activities, with little consideration paid native functions. However, more recent evidence gathered from study inter-organismal interactions has revealed influence these metabolites upon ecological adaptation distribution hosts, as well modes communication. The increasing number sequenced genomes associated transcriptomes also unveiled widespread occurrence underlying biosynthetic enzymes across all kingdoms life, important contributions they make physiological events specific each organism. This review depicts diversity roles fulfilled by type I polyketides, particularly light studies carried out during last decade, providing an initial overall picture diverse
Language: Английский
Citations
1
Nature Chemical Biology, Journal Year: 2024, Volume and Issue: 20(9), P. 1100 - 1102
Published: July 30, 2024
Language: Английский
Citations
0
Natural Product Reports, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
A personal selection of 32 recent papers is presented covering various aspects current developments in bioorganic chemistry and novel natural products such as asperochone from
Language: Английский
Citations
0