Cell Reports,
Journal Year:
2019,
Volume and Issue:
29(7), P. 1961 - 1973.e4
Published: Nov. 1, 2019
Sex
differences
in
autoimmunity
and
infection
suggest
that
a
better
understanding
of
molecular
sex
will
improve
the
diagnosis
treatment
immune-related
disease.
We
identified
144
differentially
expressed
genes,
referred
to
as
immune
expression
signature
(iSEXS),
between
human
males
females
using
an
integrated
multi-cohort
analysis
blood
transcriptome
profiles
from
six
discovery
cohorts
five
continents
with
458
healthy
individuals.
validated
iSEXS
11
additional
524
peripheral
samples.
When
we
separated
into
genes
located
on
chromosomes
(XY-iSEXS)
or
autosomes
(autosomal-iSEXS),
both
modules
distinguished
females.
reflects
cell
proportions,
female-associated
showing
higher
by
CD4+
T
cells
male-associated
myeloid
cells.
Autosomal-iSEXS
detected
increase
monocytes
age
females,
reflected
sex-differential
dynamics
during
influenza
infection,
predicted
antibody
response
males,
but
not
Cell,
Journal Year:
2018,
Volume and Issue:
174(5), P. 1277 - 1292.e14
Published: Aug. 1, 2018
Epidemiological
data
suggest
that
early
life
exposures
are
key
determinants
of
immune-mediated
disease
later
in
life.
Young
children
also
particularly
susceptible
to
infections,
warranting
more
analyses
immune
system
development
Such
mostly
have
been
performed
mouse
models
or
human
cord
blood
samples,
but
these
cannot
account
for
the
complex
environmental
influencing
newborns
after
birth.
Here,
we
longitudinal
100
newborn
children,
sampled
up
4
times
during
their
first
3
months
From
μL
blood,
analyze
58
cell
populations
by
mass
cytometry
and
267
plasma
proteins
immunoassays,
uncovering
drastic
changes
not
predictable
from
measurements
following
a
stereotypic
pattern.
Preterm
term
differ
at
birth
converge
onto
shared
trajectory,
seemingly
driven
microbial
interactions
hampered
gut
bacterial
dysbiosis.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Feb. 6, 2020
Differences
in
immune
function
and
responses
contribute
to
health-
life-span
disparities
between
sexes.
However,
the
role
of
sex
system
aging
is
not
well
understood.
Here,
we
characterize
peripheral
blood
mononuclear
cells
from
172
healthy
adults
22-93
years
age
using
ATAC-seq,
RNA-seq,
flow
cytometry.
These
data
reveal
a
shared
epigenomic
signature
including
declining
naïve
T
cell
increasing
monocyte
cytotoxic
functions.
changes
are
greater
magnitude
men
accompanied
by
male-specific
decline
B-cell
specific
loci.
Age-related
first
spike
around
late-thirties
with
similar
timing
sexes,
whereas
second
earlier
stronger
men.
Unexpectedly,
genomic
differences
sexes
increase
after
65,
having
higher
innate
pro-inflammatory
activity
lower
adaptive
activity.
Impact
on
phenotypes
can
be
visualized
at
https://immune-aging.jax.org
provide
insights
into
future
studies.
Science,
Journal Year:
2020,
Volume and Issue:
369(6511)
Published: Sept. 25, 2020
Although
the
development
of
effective
vaccines
has
saved
countless
lives
from
infectious
diseases,
basic
workings
human
immune
system
are
complex
and
have
required
animal
models,
such
as
inbred
mice,
to
define
mechanisms
immunity.
More
recently,
new
strategies
technologies
been
developed
directly
explore
with
unprecedented
precision.
We
discuss
how
these
approaches
advancing
our
mechanistic
understanding
immunology
facilitating
therapeutics
for
infection,
autoimmune
cancer.
Tobacco Induced Diseases,
Journal Year:
2020,
Volume and Issue:
18(July)
Published: July 14, 2020
1.
Chinese
Center
for
Disease
Control
and
Prevention.
[2018
Adult
Tobacco
Survey
Report].
http://www.chinacdc.cn/jkzt/st....
Published
2019.
Accessed
December
24,
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