Nature Immunology,
Journal Year:
2024,
Volume and Issue:
25(5), P. 847 - 859
Published: April 24, 2024
Abstract
Immune
cells
need
to
sustain
a
state
of
constant
alertness
over
lifetime.
Yet,
little
is
known
about
the
regulatory
processes
that
control
fluent
and
fragile
balance
called
homeostasis.
Here
we
demonstrate
JAK-STAT
signaling,
beyond
its
role
in
immune
responses,
major
regulator
cell
We
investigated
JAK-STAT-mediated
transcription
chromatin
accessibility
across
12
mouse
models,
including
knockouts
all
STAT
factors
TYK2
kinase.
Baseline
signaling
was
detected
CD8
+
T
macrophages
unperturbed
mice—but
abrogated
unstimulated
deprived
their
normal
tissue
context.
observed
diverse
gene-regulatory
programs,
effects
STAT2
IRF9
were
independent
STAT1.
In
summary,
our
large-scale
dataset
integrative
analysis
mutant
wild-type
mice
uncovered
crucial
cells,
where
it
contributes
poised
epigenetic
transcriptional
helps
prepare
these
for
rapid
response
stimuli.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6578 - 6578
Published: March 31, 2023
Systemic
lupus
erythematosus
(SLE)
is
a
genetically
predisposed,
female-predominant
disease,
characterized
by
multiple
organ
damage,
that
in
its
most
severe
forms
can
be
life-threatening.
The
pathogenesis
of
SLE
complex
and
involves
cells
both
innate
adaptive
immunity.
distinguishing
feature
the
production
autoantibodies,
with
formation
immune
complexes
precipitate
at
vascular
level,
causing
damage.
Although
progress
understanding
has
been
slower
than
other
rheumatic
diseases,
new
knowledge
recently
led
to
development
effective
targeted
therapies,
hold
out
hope
for
personalized
therapy.
However,
drugs
available
date
are
still
an
adjunct
conventional
therapy,
which
known
toxic
short
long
term.
purpose
this
review
summarize
recent
advances
disease
discuss
results
obtained
from
use
drugs,
look
future
therapies
may
used
absence
current
standard
care
or
even
cure
serious
systemic
autoimmune
disease.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 3038 - 3038
Published: Feb. 3, 2023
Lichen
planus
is
a
chronic
disease
affecting
the
skin,
appendages,
and
mucous
membranes.
A
cutaneous
lichen
rare
occurring
in
less
than
1%
of
general
population,
while
oral
illness
up
to
five
times
more
prevalent;
still,
both
forms
equally
impair
patient’s
quality
life.
The
etiology
not
entirely
understood.
Yet,
immune-mediated
mechanisms
have
been
recognized
since
environmental
factors
such
as
hepatitis
virus
infection,
mechanical
trauma,
psychological
stress,
or
microbiome
changes
can
trigger
genetically
susceptible
individuals.
According
current
understanding,
immunopathogenesis
caused
by
cell-mediated
cytotoxicity,
particularly
cytotoxic
T
lymphocytes,
whose
activity
further
influenced
Th1
IL-23/Th-17
axis.
However,
other
immunocytes
inflammatory
pathways
complement
these
mechanisms.
This
paper
presents
comprehensive
insight
into
actual
knowledge
about
planus,
with
causal
genetic
being
discussed,
described,
principal
effectors
its
circuits
identified.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 18, 2023
Interferon-gamma
(IFN-γ)
has
been
identified
as
a
crucial
factor
in
determining
the
responsiveness
to
immunotherapy.
Produced
primarily
by
natural
killer
(NK)
and
T
cells,
IFN-γ
promotes
activation,
maturation,
proliferation,
cytokine
expression,
effector
function
immune
while
simultaneously
inducing
antigen
presentation,
growth
arrest,
apoptosis
tumor
cells.
However,
cells
can
hijack
signaling
pathway
mount
resistance:
rather
than
increasing
antigenicity
succumbing
death,
acquire
stemness
characteristics
express
immunosuppressive
molecules
defend
against
antitumor
immunity.
In
this
review,
we
summarize
potential
mechanisms
of
resistance
occurring
at
two
critical
stages:
disrupted
signal
transduction
along
IFNG/IFNGR/JAK/STAT
pathway,
or
preferential
expression
specific
interferon-stimulated
genes
(ISGs).
Elucidating
molecular
through
which
develop
help
identify
promising
therapeutic
targets
improve
immunotherapy,
with
broad
application
value
conjugation
targeted,
antibody
cellular
therapies.
Nature Immunology,
Journal Year:
2024,
Volume and Issue:
25(5), P. 847 - 859
Published: April 24, 2024
Abstract
Immune
cells
need
to
sustain
a
state
of
constant
alertness
over
lifetime.
Yet,
little
is
known
about
the
regulatory
processes
that
control
fluent
and
fragile
balance
called
homeostasis.
Here
we
demonstrate
JAK-STAT
signaling,
beyond
its
role
in
immune
responses,
major
regulator
cell
We
investigated
JAK-STAT-mediated
transcription
chromatin
accessibility
across
12
mouse
models,
including
knockouts
all
STAT
factors
TYK2
kinase.
Baseline
signaling
was
detected
CD8
+
T
macrophages
unperturbed
mice—but
abrogated
unstimulated
deprived
their
normal
tissue
context.
observed
diverse
gene-regulatory
programs,
effects
STAT2
IRF9
were
independent
STAT1.
In
summary,
our
large-scale
dataset
integrative
analysis
mutant
wild-type
mice
uncovered
crucial
cells,
where
it
contributes
poised
epigenetic
transcriptional
helps
prepare
these
for
rapid
response
stimuli.
