Heat-killed Mycobacterium tuberculosis induces trained immunity in vitro and in vivo administered systemically or intranasally

iScience, Journal Year: 2024, Volume and Issue: 27(2), P. 108869 - 108869

Published: Jan. 11, 2024

Trained immunity (TI) represents a memory-like process of innate immune cells. TI can be initiated with various compounds such as fungal β-glucan or the tuberculosis vaccine, Bacillus Calmette-Guérin. Nevertheless, considering clinical applications harnessing against infections and cancer, there is growing need for new, simple, easy-to-use inducers. Here, we demonstrate that heat-killed Mycobacterium (HKMtb) induces both in vitro vivo. In human monocytes, this effect truly trained process, HKMtb confers boosted inflammatory responses heterologous challenges, lipopolysaccharide (Toll-like receptor [TLR] 4 ligand) R848 (TLR7/8 ligand). Mechanistically, HKMtb-induced relies on epigenetic mechanisms Syk/HIF-1α-dependent manner. vivo, induced when administered systemically intranasally, latter generating more robust response. Summarizing, our research has demonstrated potential to act mucosal immunotherapy successfully induce responses.

Language: Английский

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Endotoxin tolerance and trained immunity: breaking down immunological memory barriers

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 29, 2024

For decades, innate immune cells were considered unsophisticated first responders, lacking the adaptive memory of their T and B cell counterparts. However, mounting evidence demonstrates surprising complexity immunity. Beyond quickly deploying specialized initiating inflammation, two fascinating phenomena – endotoxin tolerance (ET) trained immunity (TI) have emerged. ET, characterized by reduced inflammatory response upon repeated exposure, protects against excessive inflammation. Conversely, TI leads to an enhanced after initial priming, allowing system mount stronger defences subsequent challenges. Although seemingly distinct, these may share underlying mechanisms functional implications, blurring lines between them. This review will delve into ET TI, dissecting similarities, differences, remaining questions that warrant further investigation.

Language: Английский

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Engineered polysaccharides for controlling innate and adaptive immune responses

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(9), P. 733 - 751

Published: June 18, 2024

Language: Английский

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Innate Immune Training Initiates Efferocytosis to Protect against Lung Injury

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Jan. 26, 2024

Abstract Innate immune training involves myelopoiesis, dynamic gene modulation, and functional reprogramming of myeloid cells in response to secondary heterologous challenges. The present study evaluates whether systemic innate can protect tissues from local injury. Systemic pretreatment mice with β‐glucan, a trained immunity agonist, reduces the mortality rate bleomycin‐induced lung injury fibrosis, as well decreasing collagen deposition lungs. β‐Glucan induces neutrophil accumulation lungs enhances efferocytosis. Training β‐glucan results histone modification both alveolar macrophages (AMs) neighboring epithelial cells. also increases production RvD1 soluble mediators by AMs efferocytes. Efferocytosis stimulating release, thus inducing SIRT1 expression Elevated is associated decreased cell apoptosis after injury, attenuating tissue damage. Further, depletion dampens effects on macrophage accumulation, epigenetic macrophages, expression, injury‐mediated fibrosis lung. These findings provide mechanistic insights into clues potential ability centrally peripheral organs against disorders.

Language: Английский

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Natural product/diet-based regulation of macrophage polarization: Implications in treatment of inflammatory-related diseases and cancer

The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: 130, P. 109647 - 109647

Published: April 10, 2024

Language: Английский

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