Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 19, 2024
Background
High
dietary
sodium
intake
is
a
major
cardiovascular
risk
factor
and
adversely
affects
blood
pressure
control.
Patients
with
primary
aldosteronism
(PA)
are
at
increased
risk,
even
after
medical
treatment,
high
common
in
these
patients.
Here,
we
analyze
the
impact
of
moderate
restriction
on
microbiome
composition
immunophenotype
patients
PA.
Methods
Prospective
two-stage
clinical
trial
including
two
subgroups:
15
treatment-naive
PA
compared
to
matched
normotensive
controls;
31
mineralocorticoid
receptor
antagonist
treatment
before
three
months
restriction.
underwent
measurements,
laboratory
tests,
analysis
peripheral
mononuclear
cells
via
flow
cytometry
analysis.
Results
We
observed
higher
percentage
Tregs
(p
=
0.0303),
while
abundance
Bacteroides
uniformis
was
controls
0.00027)
Lactobacillus
species
however
subgroup
0.0290).
Sodium
accompanied
by
decrease
pro-inflammatory
Tc17
male
0.0081,
females
p
0.3274).
female
(0.01230,
0.0016)
decreased
upon
(0.002309,
0.0068).
Conclusion
Dietary
modulates
immune
cell
toward
less
inflammatory
phenotype.
This
suggests
potential
mechanism
which
reduction
composition,
leading
positively
impacting
risk.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 29, 2025
Dietary
behaviors
significantly
influence
tumor
progression,
with
increasing
focus
on
high-salt
diets
(HSD)
in
recent
years.
Traditionally,
HSD
has
been
regarded
as
a
major
risk
factor
for
multiple
health
issues,
including
hypertension,
cardiovascular
disease,
kidney
cancer,
and
osteoporosis.
However,
studies
have
uncovered
novel
aspect
of
HSD,
suggesting
that
may
inhibit
growth
specific
pathological
conditions
by
modulating
the
activity
immune
cells
infiltrate
tumors
enhancing
effectiveness
PD-1
immunotherapy.
This
review
focused
duel
molecular
mechanisms
cancer
development,
which
are
based
microenvironment,
gut
microbiota,
involvement
sodium
transporter
channels.
The
objective
this
is
to
explore
whether
could
be
potential
future
oncological
therapeutic
strategy
under
situation.
Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
31(1)
Published: Feb. 19, 2025
FOLFOX
is
the
recommended
chemotherapy
regimen
for
colorectal
cancer
(CRC),
but
its
response
rate
remains
low.
Our
previous
studies
have
established
a
close
relationship
between
gut
microbiota
and
anti-CRC
effect
of
FOLFOX,
though
underlying
mechanisms
remain
unclear.
Diet
has
been
confirmed
as
key
factor
influencing
microbiota,
high-salt
diets,
representative
western
dietary
habits,
shown
to
affect
immune
function,
risk
developing
CRC.
However,
impact
diets
on
efficacy
unstudied.
Therefore,
we
aimed
investigate
mechanism
FOLFOX.
We
performed
16
S
rRNA
sequencing
T500
targeted
metabolomics
analysis
fecal
samples
from
CRC
patients
healthy
adults.
A
orthotopic
xenograft
mouse
model
was
used
study
diet
FOLFOX's
efficacy.
non-targeted
were
conducted
samples.
Flow
cytometry
assess
cell
infiltration
in
tumor
paracancerous
tissues.
macrophage
conditioned
medium
system,
with
tryptophan
metabolites,
employed
annotate
functional
followed
by
vivo
verification
using
model.
The
structure
metabolic
profiles
are
significantly
different
9
adults
6
patients.
reduced
mice,
notable
changes
related
metabolites.
Correlation
revealed
significant
metabolites
indicated
that
altered
(CD45+F4/80+)
both
In
vitro
experiments
metabolite
SK
efficacy,
while
IPA
enhanced
it
through
macrophage-conditioned
medium.
vivo,
verified
under
diet,
inhibited
promoted
it.
reduces
bacterial
metabolism
mediated
immunomodulation.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 28, 2025
Abstract
Ionic
imbalance
in
the
tumor
microenvironment
alters
tumor-infiltrating
T
lymphocyte
function.
High
extracellular
K
+
suppresses
cell
function
by
negatively
regulating
receptor
(TCR)
signaling.
In
contrast,
elevated
Na
enhances
effector
boosting
phosphorylation
of
TCR
signaling
modules.
Here,
we
presented
a
mechanism
explaining
how
two
monovalent
cations
differently
regulate
At
rest,
high
intracellular
uncouples
allosteric
recruitment
ZAP-70,
key
module,
to
complex.
The
formation
antigen
complex
induces
efflux,
causing
spontaneous
ZAP-70
TCR.
Increasing
perturbs
efflux
and
slows
complex,
even
upon
binding.
This
leads
defects
development
arthritis-like
symptoms
juvenile
mice.
We
conclude
that
dynamics
is
integral
ligand
discrimination
fundamental
turning
off
during
quiescence.
