Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease – novel insights into cellular communication circuits DOI Creative Commons
Moritz Peiseler, Robert F. Schwabe, Jochen Hampe

et al.

Journal of Hepatology, Journal Year: 2022, Volume and Issue: 77(4), P. 1136 - 1160

Published: June 22, 2022

Language: Английский

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis DOI Creative Commons
Ross Dobie, John R. Wilson‐Kanamori, Beth E. P. Henderson

et al.

Cell Reports, Journal Year: 2019, Volume and Issue: 29(7), P. 1832 - 1847.e8

Published: Nov. 1, 2019

Iterative liver injury results in progressive fibrosis disrupting hepatic architecture, regeneration potential, and function. Hepatic stellate cells (HSCs) are a major source of pathological matrix during thought to be functionally homogeneous population. Here, we use single-cell RNA sequencing deconvolve the mesenchyme healthy fibrotic mouse liver, revealing spatial zonation HSCs across lobule. Furthermore, show that partition into topographically diametric lobule regions, designated portal vein-associated (PaHSCs) central (CaHSCs). Importantly uncover functional zonation, identifying CaHSCs as dominant pathogenic collagen-producing model centrilobular fibrosis. Finally, identify LPAR1 therapeutic target on CaHSCs, demonstrating blockade inhibits rodent NASH model. Taken together, our work illustrates power transcriptomics resolve key driving with high precision.

Language: Английский

Citations

337
Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output DOI Creative Commons

Qiyi Zhao,

Jiayu Liu,

Hong Deng

et al.

Cell, Journal Year: 2020, Volume and Issue: 183(1), P. 76 - 93.e22

Published: Sept. 14, 2020

Language: Английский

Citations

336
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer DOI
Mohsen Malehmir, Dominik Pfister, Suchira Gallage

et al.

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(4), P. 641 - 655

Published: April 1, 2019

Language: Английский

Citations

318
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease DOI
Dongdong Wang, Emily A. Day, Logan K. Townsend

et al.

Nature Reviews Endocrinology, Journal Year: 2021, Volume and Issue: 17(10), P. 592 - 607

Published: Aug. 11, 2021

Language: Английский

Citations

315
Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease – novel insights into cellular communication circuits DOI Creative Commons
Moritz Peiseler, Robert F. Schwabe, Jochen Hampe

et al.

Journal of Hepatology, Journal Year: 2022, Volume and Issue: 77(4), P. 1136 - 1160

Published: June 22, 2022

Language: Английский

Citations

312