Immunotherapy,
represented
by
immune
checkpoint
inhibitors
(ICI),
is
transforming
the
treatment
of
cancer.
However,
only
a
small
percentage
patients
show
response
to
ICI,
and
there
an
unmet
need
for
biomarkers
that
will
identify
who
are
more
likely
respond
immunotherapy.
The
fundamental
basis
ICI
immunogenicity
tumor,
which
primarily
determined
tumor
antigenicity
antigen
presentation
efficiency.
Here,
we
propose
method
measure
score
(TIGS),
combines
mutational
burden
(TMB)
expression
signature
processing
presenting
machinery
(APM).
In
both
correlation
with
pan-cancer
objective
rates
(ORR)
clinical
prediction
individual
patients,
TIGS
consistently
showed
improved
performance
compared
TMB
other
known
response.
This
study
suggests
effective
tumor-inherent
biomarker
ICI-response
prediction.
Clinical Cancer Research,
Journal Year:
2019,
Volume and Issue:
26(2), P. 487 - 504
Published: Oct. 21, 2019
Abstract
Purpose:
Response
rates
to
immune
checkpoint
blockade
(ICB;
anti-PD-1/anti-CTLA-4)
correlate
with
the
extent
of
tumor
infiltrate,
but
mechanisms
underlying
recruitment
T
cells
following
therapy
are
poorly
characterized.
A
greater
understanding
these
processes
may
see
development
therapeutic
interventions
that
enhance
T-cell
and,
consequently,
improved
patient
outcomes.
We
therefore
investigated
chemokines
essential
for
cell
and
subsequent
efficacy
immunotherapies.
Experimental
Design:
The
upregulated
by
dual
PD-1/CTLA-4
were
assessed
using
NanoString-based
analysis
results
confirmed
at
protein
level
flow
cytometry
cytometric
bead
array.
Blocking/neutralizing
antibodies
requirement
key
chemokines/cytokines
effector
cells.
Results
in
patients
treated
inhibitors
single-cell
RNA-sequencing
(RNA-seq)
paired
survival
analyses.
Results:
CXCR3
ligands,
CXCL9
CXCL10,
significantly
both
CD8+
infiltration
dependent.
In
murine
models
undergoing
immunotherapy,
macrophages
predominant
source
their
depletion
abrogated
ICB.
Single-cell
RNA-seq
tumor-infiltrating
lymphocytes
(TIL)
revealed
CXCL9/10/11
was
predominantly
expressed
ICB
we
identified
a
distinct
macrophage
signature
associated
positive
responses
Conclusions:
These
data
underline
fundamental
importance
macrophage-derived
ligands
highlight
potential
manipulating
this
axis
responses.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Aug. 13, 2022
Regulated
cell
death
(RCD),
also
well-known
as
programmed
(PCD),
refers
to
the
form
of
that
can
be
regulated
by
a
variety
biomacromolecules,
which
is
distinctive
from
accidental
(ACD).
Accumulating
evidence
has
revealed
RCD
subroutines
are
key
features
tumorigenesis,
may
ultimately
lead
establishment
different
potential
therapeutic
strategies.
Hitherto,
targeting
with
pharmacological
small-molecule
compounds
been
emerging
promising
avenue,
rapidly
progressed
in
many
types
human
cancers.
Thus,
this
review,
we
focus
on
summarizing
not
only
apoptotic
and
autophagy-dependent
signaling
pathways,
but
crucial
pathways
other
subroutines,
including
necroptosis,
pyroptosis,
ferroptosis,
parthanatos,
entosis,
NETosis
lysosome-dependent
(LCD)
cancer.
Moreover,
further
discuss
current
situation
several
improve
cancer
treatment,
such
single-target,
dual
or
multiple-target
compounds,
drug
combinations,
some
new
strategies
would
together
shed
light
future
directions
attack
vulnerabilities
drugs
for
purposes.
Journal of Hematology & Oncology,
Journal Year:
2020,
Volume and Issue:
13(1)
Published: Dec. 1, 2020
Abstract
Over
the
past
few
decades,
RNA
sequencing
has
significantly
progressed,
becoming
a
paramount
approach
for
transcriptome
profiling.
The
revolution
from
bulk
to
single-molecular,
single-cell
and
spatial
approaches
enabled
increasingly
accurate,
individual
cell
resolution
incorporated
with
information.
Cancer,
major
malignant
heterogeneous
lethal
disease,
remains
an
enormous
challenge
in
medical
research
clinical
treatment.
As
vital
tool,
been
utilized
many
aspects
of
cancer
therapy,
including
biomarker
discovery
characterization
heterogeneity
evolution,
drug
resistance,
immune
microenvironment
immunotherapy,
neoantigens
so
on.
In
this
review,
latest
studies
on
technology
their
applications
are
summarized,
future
challenges
opportunities
discussed.
Cancer Communications,
Journal Year:
2022,
Volume and Issue:
42(2), P. 88 - 116
Published: Feb. 1, 2022
Abstract
The
hallmark
of
tumorigenesis
is
the
successful
circumvention
cell
death
regulation
for
achieving
unlimited
replication
and
immortality.
Ferroptosis
a
newly
identified
type
dependent
on
lipid
peroxidation
which
differs
from
classical
programmed
in
terms
morphology,
physiology
biochemistry.
broad
spectrum
injury
tumor
tolerance
are
main
reasons
radiotherapy
chemotherapy
failure.
effective
rate
immunotherapy
as
new
treatment
method
less
than
30%.
can
be
seen
radiotherapy,
chemotherapy,
immunotherapy;
therefore,
ferroptosis
activation
may
potential
strategy
to
overcome
drug
resistance
mechanism
traditional
cancer
treatments.
In
this
review,
characteristics
causes
by
briefly
described.
addition,
three
metabolic
regulations
its
crosstalk
with
signaling
pathways
summarized.
Collectively,
these
findings
suggest
vital
role
based
interaction
immunotherapy,
thus,
indicating
remarkable
treatment.
Biomarker Research,
Journal Year:
2020,
Volume and Issue:
8(1)
Published: Aug. 26, 2020
Abstract
Although
the
clinical
development
of
immune
checkpoint
inhibitors
(ICIs)
therapy
has
ushered
in
a
new
era
anti-tumor
therapy,
with
sustained
responses
and
significant
survival
advantages
observed
multiple
tumors,
most
patients
do
not
benefit.
Therefore,
more
attention
been
paid
to
identification
predictive
biomarkers
for
response
ICIs,
in-depth
comprehensive
understanding
continuously
explored
recent
years.
Predictive
markers
ICIs
efficacy
have
gradually
from
expression
intermolecular
interactions
within
tumor
cells
various
molecules
microenvironment,
extended
exploration
circulating
host
systemic
markers.
With
high-throughput
sequencing
microarray
technology,
variety
biomarker
strategies
deeply
achieved
process
single
marker
multifactorial
synergistic
Comprehensive
predictive-models
developed
by
integrating
different
types
data
based
on
components
tumor-host
is
direction
future
research
will
profound
impact
field
precision
immuno-oncology.
In
this
review,
we
analyze
course
progress
as
an
adjunctive
tool
immunotherapy
effectively
identifying
discuss
their
directions
achieving
