Persistent COVID-19 symptoms in a community study of 606,434 people in England DOI Creative Commons
Matthew Whitaker, Joshua Elliott, Marc Chadeau‐Hyam

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: April 12, 2022

Long COVID remains a broadly defined syndrome, with estimates of prevalence and duration varying widely. We use data from rounds 3-5 the REACT-2 study (n = 508,707; September 2020 - February 2021), representative community survey adults in England, replication round 6 97,717; May 2021) to estimate identify predictors persistent symptoms lasting 12 weeks or more; unsupervised learning cluster individuals by reported symptoms. At 3-5, 37.7% experienced at least one symptom, falling 21.6% 6. Female sex, increasing age, obesity, smoking, vaping, hospitalisation COVID-19, deprivation, being healthcare worker are associated higher probability Asian ethnicity lower probability. Clustering analysis identifies subset participants predominantly respiratory Managing long-term sequelae COVID-19 will remain major challenge for affected their families health services.

Language: Английский

Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers DOI Open Access
Sebastian Havervall, Axel Rosell, Mia Phillipson

et al.

JAMA, Journal Year: 2021, Volume and Issue: 325(19), P. 2015 - 2015

Published: April 7, 2021

This cohort study describes COVID-19–related symptoms persisting 8 months after SARS-CoV-2 infection among Swedish health care workers and self-reported effects of the residual on respondents' home, work, social function.

Language: Английский

Citations

374

Psychiatric and neuropsychiatric sequelae of COVID-19 – A systematic review DOI Creative Commons

Thor Mertz Schou,

Sâmia R.L. Joca, Gregers Wegener

et al.

Brain Behavior and Immunity, Journal Year: 2021, Volume and Issue: 97, P. 328 - 348

Published: July 30, 2021

It has become evident that coronavirus disease 2019 (COVID-19) a multi-organ pathology includes the brain and nervous system. Several studies have also reported acute psychiatric symptoms in COVID-19 patients. An increasing number of are suggesting deficits may persist after recovery from primary infection. In current systematic review, we provide an overview available evidence supply information on potential risk factors underlying biological mechanisms behind such sequelae. We performed search for sequelae patients using databases PubMed Embase. Included all contained follow-up period provided quantitative measures mental health. The was June 4th 2021. 1725 unique were identified. Of these, 66 met inclusion criteria included. Time to ranged immediately hospital discharge up 7 months discharge, participants spanned 3 266,586 participants. Forty anxiety and/or depression, 20 symptoms- or diagnoses post-traumatic stress disorder (PTSD), 27 cognitive deficits, 32 articles found fatigue at follow-up, sleep disturbances 23 studies. Highlighted severity, duration symptoms, female sex. One study showed abnormalities correlating with several inflammatory markers correlate symptoms. Overall, results this review suggest survivors but generally improve over time.

Language: Английский

Citations

372

Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)—A Systemic Review and Comparison of Clinical Presentation and Symptomatology DOI Creative Commons

Timothy L. Wong,

Danielle Weitzer

Medicina, Journal Year: 2021, Volume and Issue: 57(5), P. 418 - 418

Published: April 26, 2021

Background and Objectives: Long COVID defines a series of chronic symptoms that patients may experience after resolution acute COVID-19. Early reports from studies with long suggests constellation similarities to another medical illness—myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A review study comparing contrasting ME/CFS reported yield mutualistic insight into the characterization management both conditions. Materials Methods: systemic literature search was conducted in MEDLINE PsycInfo through 31 January 2021 for related symptomatology. The accordance PRISMA methodology. Results: Twenty-one were included qualitative analysis. by compared list compiled multiple case definitions. Twenty-five out 29 known at least one selected study. Conclusions: symptomatology suggest many overlaps clinical presentation ME/CFS. need monitoring treatment post-COVID is evident. Advancements standardization research methodologies would improve quality future research, allow further investigations differences between

Language: Английский

Citations

365

Long-term complications of COVID-19 DOI Open Access
Amar D. Desai,

Michael P. Lavelle,

Brian C. Boursiquot

et al.

AJP Cell Physiology, Journal Year: 2021, Volume and Issue: 322(1), P. C1 - C11

Published: Nov. 24, 2021

SARS-CoV-2 has rapidly spread across the globe and infected hundreds of millions people worldwide. As our experience with this virus continues to grow, understanding both short-term long-term complications infection grow as well. Just there is heterogeneity in acute infectious phase, seen following COVID-19 illness. The purpose review article present current literature regards epidemiology, pathophysiology, proposed management algorithms for various sequelae that have been observed each organ system SARS-CoV-2. We will also consider future directions, newer variants their potential impact on observed.

Language: Английский

Citations

362

Persistent COVID-19 symptoms in a community study of 606,434 people in England DOI Creative Commons
Matthew Whitaker, Joshua Elliott, Marc Chadeau‐Hyam

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: April 12, 2022

Long COVID remains a broadly defined syndrome, with estimates of prevalence and duration varying widely. We use data from rounds 3-5 the REACT-2 study (n = 508,707; September 2020 - February 2021), representative community survey adults in England, replication round 6 97,717; May 2021) to estimate identify predictors persistent symptoms lasting 12 weeks or more; unsupervised learning cluster individuals by reported symptoms. At 3-5, 37.7% experienced at least one symptom, falling 21.6% 6. Female sex, increasing age, obesity, smoking, vaping, hospitalisation COVID-19, deprivation, being healthcare worker are associated higher probability Asian ethnicity lower probability. Clustering analysis identifies subset participants predominantly respiratory Managing long-term sequelae COVID-19 will remain major challenge for affected their families health services.

Language: Английский

Citations

343