Nature Mental Health, Journal Year: 2023, Volume and Issue: 1(10), P. 772 - 781
Published: Sept. 25, 2023
Language: Английский
Biological Psychiatry, Journal Year: 2024, Volume and Issue: 95(12), P. 1091 - 1099
Published: Jan. 10, 2024
Language: Английский
Citations
67
JAMA Neurology, Journal Year: 2023, Volume and Issue: 80(9), P. 891 - 891
Published: July 3, 2023
Importance It remains unclear why lesions in some locations cause epilepsy while others do not. Identifying the brain regions or networks associated with by mapping these could inform prognosis and guide interventions. Objective To assess whether lesion map to specific networks. Design, Setting, Participants This case-control study used location network identify a discovery data set of patients poststroke control stroke. Patients stroke (n = 76) no 625) were included. Generalizability other types was assessed using 4 independent cohorts as validation sets. The total numbers across all datasets (both datasets) 347 1126 without. Therapeutic relevance deep stimulation sites that improve seizure control. Data analyzed from September 2018 through December 2022. All shared patient included; excluded. Main Outcomes Measures Epilepsy epilepsy. Results Lesion 76 (39 [51%] male; mean [SD] age, 61.0 [14.6] years; follow-up, 6.7 [2.0] years) 625 (366 [59%] 62.0 [14.1] follow-up range, 3-12 months) included set. Lesions occurred multiple heterogenous spanning different lobes vascular territories. However, same part defined functional connectivity basal ganglia cerebellum. Findings validated including 772 (271 [35%] epilepsy; 515 [67%] median [IQR] 60 [50-70] 3-35 years). this increased risk after (odds ratio [OR], 2.82; 95% CI, 2.02-4.10; P < .001) (OR, 2.85; 2.23-3.69; .001). Deep site improved ( r , 0.63; 30 drug-resistant (21 [70%] 39 [32-46] 24 [16-30] months). Conclusions Relevance findings indicate lesion-related mapped human network, which help at therapies.
Language: Английский
Citations
53
Schizophrenia Bulletin, Journal Year: 2024, Volume and Issue: 50(6), P. 1326 - 1336
Published: Feb. 24, 2024
Abstract Background and Hypothesis Neuroimaging studies investigating the neural substrates of auditory verbal hallucinations (AVH) in schizophrenia have yielded mixed results, which may be reconciled by network localization. We sought to examine whether AVH-state AVH-trait brain alterations localize common or distinct networks. Study Design initially identified reported 48 previous studies. By integrating these affected locations with large-scale discovery validation resting-state functional magnetic resonance imaging datasets, we then leveraged novel connectivity mapping construct dysfunctional Results The neuroanatomically heterogeneous localized specific comprised a broadly distributed set regions mainly involving auditory, salience, basal ganglia, language, sensorimotor Contrastingly, manifested as pattern circumscribed principally implicating caudate inferior frontal gyrus. Additionally, aligned neuromodulation targets for effective treatment AVH, indicating possible clinical relevance. Conclusions Apart from unifying seemingly irreproducible neuroimaging results across prior AVH studies, our findings suggest different mechanisms underlying state trait perspective more inform future AVH.
Language: Английский
Citations
53
Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 1, 2024
Language: Английский
Citations
32
Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Language: Английский
Citations
13
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 2, 2025
Language: Английский
Citations
6
JAMA Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
Importance Identifying anatomy causally involved in psychosis could inform therapeutic neuromodulation targets for schizophrenia. Objective To assess whether lesions that cause secondary have functional connections to a common brain circuit. Design, Setting, and Participants This case-control study mapped of published cases causing compared with control unassociated psychosis. Published lesion-induced were analyzed computational laboratory. had documented associated new-onset psychotic symptoms without history Control included 1156 patients not Generalizability across lesional datasets was assessed using an independent cohort 181 who subsequently underwent neurobehavioral testing. Data from June 2022 April 2024. Exposures Lesions Main Outcomes Measures Psychosis or no Results A total 153 determined be causal psychosis, 42 which described as schizophrenia schizophrenia-like (71 [46%] male, 82 [54%] female; mean [SD] age, 50.0 [20.8] years). caused circuit defined by connectivity the posterior subiculum hippocampus (84% overlap, family-wise error [FWE] rate corrected P < 5 × 10 −5 ). At lower statistical threshold (>75% FWE-corrected −4 ), this ventral tegmental area, retrosplenial cortex, lobule IX dentate nucleus cerebellum, mediodorsal midline nuclei thalamus. consistent when derived (spatial r = 0.98). We repeated these analyses after excluding intersecting (n 47) found profile 0.98) remaining center demonstrating circuit-level effect. In observational penetrating head trauma 181), exhibited significantly similar profiles lesion-derived (suspiciousness, .03; unusual thought content, .046). Voxels rostromedial prefrontal cortex are highly correlated 0.82), suggesting promising transcranial magnetic stimulation target Conclusions Relevance affect hippocampus. These results can help targeting.
Language: Английский
Citations
2
Neuron, Journal Year: 2022, Volume and Issue: 110(16), P. 2524 - 2544
Published: Aug. 1, 2022
Language: Английский
Citations
67
Current Opinion in Neurology, Journal Year: 2022, Volume and Issue: 35(4), P. 453 - 459
Published: July 5, 2022
Focal lesions causing specific neurological or psychiatric symptoms can occur in multiple different brain locations, complicating symptom localization. Here, we review lesion network mapping, a technique used to aid localization by mapping lesion-induced circuits rather than individual regions. We highlight recent examples of how this is being investigate clinical entities and identify therapeutic targets.To date, has successfully been applied more 40 complexes. In each case, locations were combined with an atlas human connections (the connectome) map heterogeneous the same common circuit. This approach lent insight into that have difficult localize using other techniques, such as hallucinations, tics, blindsight, pathological laughter crying. Further, recently improve symptoms, tremor addiction, which may translate new targets.Lesion be single Recent findings provided long-standing mysteries identified testable treatment targets for circuit-based symptom-based neuromodulation.
Language: Английский
Citations
41
Nature Mental Health, Journal Year: 2023, Volume and Issue: 1(10), P. 736 - 750
Published: Sept. 11, 2023
Abstract Lifestyle factors have been acknowledged to be modifiable targets that can used counter the increasing prevalence of depression. This study aims investigate combining an extensive range lifestyle factors, including alcohol consumption, diet, physical activity, sleep, smoking, sedentary behavior and social connection, contribute depression, examine underlying neurobiological mechanisms. Over nine years follow-up, a multivariate Cox model was utilized on 287,282 participants from UK Biobank demonstrate protective roles seven combined score Combining genetic risk category in 197,344 participants, we found healthy decreased depression across population with varied risk. Mendelian randomization confirmed causal relationship between A broad brain regions peripheral biomarkers were related lifestyle, pallidum, precentral cortex, triglycerides C-reactive protein. Structural equation modeling 18,244 revealed mechanisms involving structure, immunometabolic function, genetics Together, our findings suggest adherence could aid prevention
Language: Английский
Citations
41