Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215677 - 215677
Published: Jan. 31, 2024
Language: Английский
Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(8), P. 526 - 543
Published: June 13, 2023
Language: Английский
Citations
219
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(51)
Published: May 17, 2023
Abstract Messenger RNA (mRNA) has received great attention in the prevention and treatment of various diseases due to success coronavirus disease 2019 (COVID‐19) mRNA vaccines (Comirnaty Spikevax). To meet therapeutic purpose, it is required that must enter target cells express sufficient proteins. Therefore, development effective delivery systems necessary crucial. Lipid nanoparticle (LNP) represents a remarkable vehicle indeed accelerated applications humans, as several mRNA‐based therapies have already been approved or are clinical trials. In this review, focus on mRNA‐LNP‐mediated anticancer therapy. It summarizes main strategies mRNA‐LNP formulations, discusses representative approaches cancer, points out current challenges possible future directions research field. hoped these delivered messages can help further improve application technology cancer
Language: Английский
Citations
180
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: March 11, 2023
Abstract The frequent outbreak of global infectious diseases has prompted the development rapid and effective diagnostic tools for early screening potential patients in point-of-care testing scenarios. With advances mobile computing power microfluidic technology, smartphone-based health platform drawn significant attention from researchers developing devices that integrate optical detection with artificial intelligence analysis. In this article, we summarize recent progress these platforms, including aspects chips, imaging modalities, supporting components, software algorithms. We document application platforms terms objects, molecules, viruses, cells, parasites. Finally, discuss prospects future platforms.
Language: Английский
Citations
111
Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)
Published: July 14, 2023
Early detection and diagnosis of many cancers is very challenging. Late stage a cancer always leads to high mortality rates. It imperative develop novel more sensitive effective therapeutic methods for treatments. The development new treatments has become crucial aspect medical advancements. Nanobots, as one the most promising applications nanomedicines, are at forefront multidisciplinary research. With progress nanotechnology, nanobots enable assembly deployment functional molecular/nanosized machines increasingly being utilized in treatment. In recent years, various practical have transitioned from theory practice, vitro experiments vivo applications. this paper, we review analyze advancements treatments, with particular emphasis on their key fundamental features drug delivery, tumor sensing diagnosis, targeted therapy, minimally invasive surgery, other comprehensive At same time, discuss challenges potential research opportunities revolutionizing future, expected sophisticated capable performing multiple functions tasks, ultimately becoming true nanosubmarines bloodstream.
Language: Английский
Citations
103
Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)
Published: Feb. 8, 2023
Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity few adverse effects. Currently, the development of functional vectors safety effectiveness is intense focus for improving delivery nucleic acid drugs gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential overall efficiencies reducing effects via effective protection, prolonged blood circulation, specific tumor accumulation, controlled release profile drugs. Besides, synergistic could be achieved when combined other therapeutic regimens. This review summarizes recent advances various delivery. Particularly, responding to endogenous stimuli including pH, reactive oxygen species, glutathione, enzyme, etc., exogenous light, thermo, ultrasound, magnetic field, are introduced. Finally, future challenges prospects toward clinical translation well discussed. The major objective present biomedical cancer provide guidance developing novel nanoplatforms that clinically applicable.
Language: Английский
Citations
90
Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)
Published: July 7, 2023
Abstract Over the past several decades, mRNA vaccines have evolved from a theoretical concept to clinical reality. These offer advantages over traditional vaccine techniques, including their high potency, rapid development, low-cost manufacturing, and safe administration. However, until recently, concerns instability inefficient distribution of in vivo limited utility. Fortunately, recent technological advancements mostly resolved these concerns, resulting development numerous vaccination platforms for infectious diseases various types cancer. shown promising outcomes both animal models humans. This study highlights potential as alternative approach conventional techniques cancer treatment. review article aims provide thorough detailed examination vaccines, mechanisms action applications immunotherapy. Additionally, will analyze current state technology highlight future directions implementation this platform mainstream therapeutic option. The also discuss challenges limitations such stability distribution, suggest ways overcome issues. By providing comprehensive overview critical analysis contribute advancement innovative
Language: Английский
Citations
85
Journal of Biomedical Science, Journal Year: 2023, Volume and Issue: 30(1)
Published: Oct. 7, 2023
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating immune system. With regard mRNA vaccines, researchers modified structure enhance its stability promote systemic tolerance of antigenic presentation non-inflammatory contexts. Still, delivery naked mRNAs is inefficient results low levels antigen protein production. As such, lipid nanoparticles been utilized improve protect cargo from extracellular degradation. This advance was milestone development vaccines dispelled skepticism about technology yield clinically approved medicines. Following resounding success COVID-19, many other proposed treatment variety diseases. review begins discussion modifications vehicles, well factors that influence administration routes. Then, we summarize applications discuss further key points pertaining preclinical targeting wide range Finally, latest market trends future drugs.
Language: Английский
Citations
74
Nature Reviews Methods Primers, Journal Year: 2023, Volume and Issue: 3(1)
Published: Aug. 17, 2023
Language: Английский
Citations
72
Materials Horizons, Journal Year: 2023, Volume and Issue: 10(10), P. 3879 - 3894
Published: Jan. 1, 2023
Structure of plant-derived vesicles and their bioactive applications. Created with BioRender.com
Language: Английский
Citations
68
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)
Published: Feb. 16, 2024
Abstract Nanomedicines are extensively explored for cancer therapy. By delivering drug molecules more efficiently to pathological sites and by attenuating their accumulation in healthy organs tissues, nanomedicine formulations aim improve the balance between efficacy toxicity. More than 20 nanomedicines approved clinical use, hundreds of (pre)clinical development. Over years, several key pitfalls have been identified as bottlenecks tumor targeting translation. These go beyond materials‐ production‐related issues, particularly also encompass biological barriers pathophysiological heterogeneity. In this manuscript, author describes most important principles, progress, products targeting, delineates current problems challenges, discusses promising future prospects create impact.
Language: Английский
Citations
68