Accelerometer-Derived “Weekend Warrior” Physical Activity and Incident Cardiovascular Disease

JAMA, Journal Year: 2023, Volume and Issue: 330(3), P. 247 - 247

Published: July 18, 2023

Importance Guidelines recommend 150 minutes or more of moderate to vigorous physical activity (MVPA) per week for overall health benefit, but the relative effects concentrated vs evenly distributed are unclear. Objective To examine associations between an accelerometer-derived “weekend warrior” pattern (ie, most MVPA achieved over 1-2 days) spread with risk incident cardiovascular events. Design, Setting, and Participants Retrospective analysis UK Biobank cohort study participants providing a full accelerometer-based data June 8, 2013, December 30, 2015. Exposures Three patterns were compared: active weekend warrior (active WW, ≥150 ≥50% total in days), regular (≥150 not meeting WW status), inactive (<150 minutes). The same assessed using sample median threshold 230.4 week. Main Outcomes Measures Associations atrial fibrillation, myocardial infarction, heart failure, stroke Cox proportional hazards regression, adjusted age, sex, racial ethnic background, tobacco use, alcohol intake, Townsend Deprivation Index, employment status, self-reported health, diet quality. Results A 89 573 individuals (mean [SD] 62 [7.8] years; 56% women) who underwent accelerometry included. When stratified at week, 37 872 group (42.2%), 21 473 (24.0%), 30 228 (33.7%). In multivariable-adjusted models, both associated similarly lower risks fibrillation WW: hazard ratio [HR], 0.78 [95% CI, 0.74-0.83]; regular: 0.81 0.74-0.88; inactive: HR, 1.00 0.94-1.07]), infarction 0.73 0.67-0.80]; 0.65 0.57-0.74]; 0.91-1.10]), failure 0.62 0.56-0.68]; 0.64 0.56-0.73]; 0.92-1.09]), 0.79 0.71-0.88]; 0.83 0.72-0.97]; 0.90-1.11]). Findings consistent although no longer significant 0.89 0.79-1.02]; 0.87 0.74-1.02]; Conclusions Relevance Physical within 1 2 days was outcomes activity.

Language: Английский

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A Perspective on High-Intensity Interval Training for Performance and Health

Sports Medicine, Journal Year: 2023, Volume and Issue: 53(S1), P. 85 - 96

Published: Oct. 7, 2023

Language: Английский

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Physical Activity Over the Lifecourse and Cardiovascular Disease

Circulation Research, Journal Year: 2023, Volume and Issue: 132(12), P. 1725 - 1740

Published: June 8, 2023

Despite improvements in cardiovascular care recent decades, disease (CVD) remains a leading cause of death worldwide. At its core, CVD is largely preventable with diligent risk factor management and early detection. As highlighted the American Heart Association's

Language: Английский

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Vigorous Intermittent Lifestyle Physical Activity and Cancer Incidence Among Nonexercising Adults

JAMA Oncology, Journal Year: 2023, Volume and Issue: 9(9), P. 1255 - 1255

Published: July 27, 2023

Vigorous physical activity (VPA) is a time-efficient way to achieve recommended (PA) for cancer prevention, although structured longer bouts of VPA (via traditional exercise) are unappealing or inaccessible many individuals.To evaluate the dose-response association device-measured daily vigorous intermittent lifestyle (VILPA) with incident cancer, and estimate minimal dose required risk reduction 50% maximum reduction.This was prospective cohort analysis 22 398 self-reported nonexercising adults from UK Biobank accelerometry subsample. Participants were followed up through October 30, 2021 (mortality hospitalizations), June (cancer registrations).Daily VILPA 1 2 minutes, assessed by accelerometers worn on participants' dominant wrist.Incidence total PA-related (a composite outcome 13 sites associated low PA levels). Hazard ratios 95% CIs estimated using cubic splines adjusted age, sex, education level, smoking status, alcohol consumption, sleep duration, fruit vegetable parental history, light- moderate-intensity PA, more than minute(s), as appropriate.The study sample comprised participants (mean [SD] 62.0 [7.6] years; 10 122 [45.2%] men 12 276 [54.8%] women; 21 509 [96.0%] White individuals). During mean (SD) follow-up 6.7 (1.2) years (149 650 person-years), 2356 events occurred, 1084 owing cancer. Almost all (92.3%) accrued in minute. Daily duration outcomes near-linear manner, steeper curves incidence. Compared no VILPA, median minute (4.5 minutes per day) an HR 0.80 (95% CI, 0.69-0.92) 0.69 0.55-0.86) The 3.4 day (HR, 0.83; 0.73-0.93) 3.7 0.72; 0.59-0.88) Findings similar bout minutes.The findings this indicate that small amounts lower risk. may be promising intervention prevention populations not able motivated exercise leisure time.

Language: Английский

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Brief bouts of device-measured intermittent lifestyle physical activity and its association with major adverse cardiovascular events and mortality in people who do not exercise: a prospective cohort study

The Lancet Public Health, Journal Year: 2023, Volume and Issue: 8(10), P. e800 - e810

Published: Sept. 28, 2023

BackgroundGuidelines emphasise the health benefits of bouts physical activity any duration. However, associations intermittent lifestyle accumulated through non-exercise with mortality and major adverse cardiovascular events (MACE) remain unclear. We aimed to examine moderate-to-vigorous (MV-ILPA) proportion vigorous contributing within these MACE.MethodsIn this prospective cohort study, we used data from UK Biobank on adults who do not exercise (ie, those did report leisure-time exercise) had wrist-worn accelerometry available. Participants were followed up until Nov 30, 2022, outcome interest all-cause obtained linkage NHS Digital England Wales, Central Register National Records Scotland, MACE inpatient hospitalisation provided by Hospital Episode Statistics for England, Patient Database Scottish Morbidity Record Scotland. MV-ILPA derived using a two-level Random Forest classifier grouped as short (<1 min), medium (1 <3 min; 3 <5 long (5 <10 min). further examined dose–response relationship bout.FindingsBetween June 1, 2013, Dec 23, 2015, 103 684 participants wore an accelerometer their wrist. 25 241 (mean age 61·8 years [SD 7·6]), whom 14 178 (56·2%) women, included in our analysis mortality. During mean follow-up duration 7·9 (SD 0·9), 824 1111 deaths occurred. Compared less than 1 min, risk was lower min (hazard ratio [HR] 0·66 [0·53–0·81]), 5 (HR 0·56 [0·46–0·69]), 10 0·48 [0·39–0·59]). Similarly, compared 0·71 [0·54–0·93]), (0·62 [0·48–0·81]), (0·59 [0·46–0·76]). Short min) associated only when comprised at least 15% activity.InterpretationIntermittent MACE. Our results support promotion intensity improve longevity among habitually leisure time.FundingAustralian Health, Medical Research Council, Wellcome Trust.

Language: Английский

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Device-measured physical activity and cardiometabolic health: the Prospective Physical Activity, Sitting, and Sleep (ProPASS) consortium

European Heart Journal, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 10, 2023

Abstract Background and Aims Physical inactivity, sedentary behaviour (SB), inadequate sleep are key behavioural risk factors of cardiometabolic diseases. Each is mainly considered in isolation, despite clear biological interdependencies. The aim this study was to investigate associations five-part movement compositions with adiposity biomarkers. Methods Cross-sectional data from six studies (n = 15 253 participants; five countries) the Prospective Activity, Sitting Sleep consortium were analysed. Device-measured time spent sleep, SB, standing, light-intensity physical activity (LIPA), moderate-vigorous (MVPA) made up composition. Outcomes included body mass index (BMI), waist circumference, HDL cholesterol, total:HDL cholesterol ratio, triglycerides, glycated haemoglobin (HbA1c). Compositional linear regression examined between outcomes, including modelling reallocation behaviours. Results average daily composition sample (age: 53.7 ± 9.7 years; 54.7% female) 7.7 h sleeping, 10.4 sedentary, 3.1 1.5 LIPA, 1.3 MVPA. A greater MVPA proportion smaller SB associated better outcomes. Reallocating or into resulted scores across all For example, replacing 30 min LIPA −0.63 (95% confidence interval −0.48, −0.79), −0.43 (−0.25, −0.59), −0.40 −0.56), −0.15 (0.05, −0.34) kg/m2 lower BMI, respectively. Greater relative standing beneficial, whereas had a detrimental association when LIPA/MVPA positive SB. minimal displacement any for improved health ranged 3.8 (HbA1c) 12.7 (triglycerides) min/day. Conclusions analyses revealed distinct hierarchy Moderate-vigorous demonstrated strongest, most time-efficient protective Theoretical benefits reallocating required substantial changes activity.

Language: Английский

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Transforming Cardiovascular Care With Artificial Intelligence: From Discovery to Practice

Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 84(1), P. 97 - 114

Published: June 24, 2024

Language: Английский

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Wearable Devices: Implications for Precision Medicine and the Future of Health Care

Annual Review of Medicine, Journal Year: 2023, Volume and Issue: 75(1), P. 401 - 415

Published: Nov. 20, 2023

Wearable devices are integrated analytical units equipped with sensitive physical, chemical, and biological sensors capable of noninvasive continuous monitoring vital physiological parameters. Recent advances in disciplines including electronics, computation, material science have resulted affordable highly wearable that routinely used for tracking managing health well-being. Combined longitudinal parameters, wearables poised to transform the early detection, diagnosis, treatment/management a range clinical conditions. Smartwatches most commonly already demonstrated valuable biomedical potential detecting conditions such as arrhythmias, Lyme disease, inflammation, and, more recently, COVID-19 infection. Despite significant promise shown research settings, there remain major hurdles translating medical uses clinic. There is clear need effective collaboration among stakeholders, users, data scientists, clinicians, payers, governments, improve device security, user privacy, standardization, regulatory approval, validity. This review examines offer reliable measures status on par FDA-approved specialized devices. We briefly examine studies where proved critical detection acute chronic particular focus cardiovascular viral infections, mental health. Finally, we discuss current obstacles implementation provide perspectives their deliver increasingly personalized proactive care across wide variety

Language: Английский

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Sleep patterns and risk of chronic disease as measured by long-term monitoring with commercial wearable devices in the All of Us Research Program

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(9), P. 2648 - 2656

Published: July 19, 2024

Abstract Poor sleep health is associated with increased all-cause mortality and incidence of many chronic conditions. Previous studies have relied on cross-sectional self-reported survey data or polysomnograms, which limitations respect to granularity, sample size longitudinal information. Here, using objectively measured, from commercial wearable devices linked electronic record the All Us Research Program, we show that patterns, including stages, duration regularity, are disease incidence. Of 6,785 participants included in this study, 71% were female, 84% self-identified as white had a college degree; median age was 50.2 years (interquartile range = 35.7, 61.5) monitoring period 4.5 (2.5, 6.5). We found rapid eye movement deep inversely odds incident atrial fibrillation irregularity obesity, hyperlipidemia, hypertension, major depressive disorder generalized anxiety disorder. Moreover, J-shaped associations observed between average daily These findings regularity all important factors development may inform evidence-based recommendations healthy sleeping habits.

Language: Английский

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Western diets and chronic diseases

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(8), P. 2133 - 2147

Published: July 31, 2024

Language: Английский

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