Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 1, 2025
We
evaluated
several
foundation
models
in
histopathology
for
image
retrieval
using
a
zero-shot
approach.
These
generated
embeddings
that
were
directly
employed
without
additional
fine-tuning.
Our
experiments
conducted
on
diagnostic
slides
from
The
Cancer
Genome
Atlas
(TCGA),
which
covers
23
organs
and
117
cancer
subtypes.
used
Yottixel
as
the
framework
whole-slide
(WSI)
via
patch-based
embeddings.
Retrieval
performance
was
macro-averaged
F1
scores
top-1,
top-3,
top-5
retrievals.
indicated
varying
levels
of
performance:
Yottixel-DenseNet
(27%
±
13%),
Yottixel-UNI
(42%
14%),
Yottixel-Virchow
(40%
Yottixel-GigaPath
(41%
GigaPath
WSI
14%).
results
demonstrate
potential
limitations
retrieval,
underscoring
need
further
advancements
embedding
techniques.
The Innovation Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100120 - 100120
Published: Jan. 1, 2025
<p>Artificial
intelligence
(AI)
is
driving
transformative
changes
in
the
field
of
medicine,
with
its
successful
application
relying
on
accurate
data
and
rigorous
quality
standards.
By
integrating
clinical
information,
pathology,
medical
imaging,
physiological
signals,
omics
data,
AI
significantly
enhances
precision
research
into
disease
mechanisms
patient
prognoses.
technologies
also
demonstrate
exceptional
potential
drug
development,
surgical
automation,
brain-computer
interface
(BCI)
research.
Through
simulation
biological
systems
prediction
intervention
outcomes,
enables
researchers
to
rapidly
translate
innovations
practical
applications.
While
challenges
such
as
computational
demands,
software
ethical
considerations
persist,
future
remains
highly
promising.
plays
a
pivotal
role
addressing
societal
issues
like
low
birth
rates
aging
populations.
can
contribute
mitigating
rate
through
enhanced
ovarian
reserve
evaluation,
menopause
forecasting,
optimization
Assisted
Reproductive
Technologies
(ART),
sperm
analysis
selection,
endometrial
receptivity
fertility
remote
consultations.
In
posed
by
an
population,
facilitate
development
dementia
models,
cognitive
health
monitoring
strategies,
early
screening
systems,
AI-driven
telemedicine
platforms,
intelligent
smart
companion
robots,
environments
for
aging-in-place.
profoundly
shapes
medicine.</p>
npj Breast Cancer,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Jan. 24, 2025
Special
histologic
subtypes
of
breast
cancer
(BC)
exhibit
unique
phenotypes
and
molecular
profiles
with
diagnostic
therapeutic
implications,
often
differing
in
behavior
clinical
trajectory
from
common
BC
forms.
Novel
methodologies,
such
as
artificial
intelligence
may
improve
classification.
Genetic
predisposition
plays
roles
a
subset
cases.
Uncommon
presentations
like
male,
inflammatory
pregnancy-related
pose
challenges.
Emerging
strategies
targeting
genetic
alterations
or
immune
microenvironment
are
being
explored.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 1, 2025
Abstract
The
foundation
model,
trained
on
extensive
and
diverse
datasets,
has
shown
strong
performance
across
numerous
downstream
tasks.
Nevertheless,
its
application
in
the
medical
domain
is
significantly
hindered
by
issues
such
as
data
volume,
heterogeneity,
privacy
concerns.
Therefore,
we
propose
Vision
Foundation
Model
General
Lightweight
(VFMGL)
framework,
which
facilitates
decentralized
construction
of
expert
clinical
models
for
various
VFMGL
framework
transfers
general
knowledge
from
large-parameter
vision
to
construct
lightweight,
robust
tailored
specific
Through
experiments
analyses
a
range
tasks
scenarios,
demonstrate
that
achieves
superior
both
image
classification
segmentation
tasks,
effectively
managing
challenges
posed
heterogeneity.
These
results
underscore
potential
advancing
efficacy
reliability
AI-driven
diagnostics.
