Advancing translational exposomics: bridging genome, exposome and personalized medicine DOI Creative Commons
Dimosthenis Sarigiannis,

Spyros Karakitsios,

Ourania Anesti

et al.

Human Genomics, Journal Year: 2025, Volume and Issue: 19(1)

Published: April 30, 2025

Understanding the interplay between genetic predisposition and environmental lifestyle exposures is essential for advancing precision medicine public health. The exposome, defined as sum of all an individual encounters throughout their lifetime, complements genomic data by elucidating how external internal exposure factors influence health outcomes. This treatise highlights emerging discipline translational exposomics that integrates genomics, offering a comprehensive approach to decipher complex relationships exposures, variability, disease phenotypes. We highlight cutting-edge methodologies, including multi-omics technologies, exposome-wide association studies (EWAS), physiology-based biokinetic modeling, advanced bioinformatics approaches. These tools enable precise characterization both facilitating identification biomarkers, exposure-response relationships, prediction mechanisms. also consider importance addressing socio-economic, demographic, gender disparities in research. emphasize exposome can contextualize variation enhance causal inference, especially vulnerable populations diseases. By showcasing concrete examples proposing integrative platforms exposomics, this work underscores critical need bridge genomics prevention, risk stratification, decision-making. offers new paradigm understanding beyond genetics alone.

Language: Английский

Environmental Health Is Overlooked in Longevity Research DOI Creative Commons
Robin Mesnage

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 421 - 421

Published: March 31, 2025

Aging is a multifactorial process influenced by genetic predisposition and lifestyle choices. Environmental exposures are too often overlooked. pollutants—ranging from airborne particulate matter heavy metals to endocrine disruptors microplastics—accelerate biological aging. Oxidative stress major molecular initiating event, driving inflammation toxicity across levels. We detail the mechanisms which pollutants enhance reactive oxygen species (ROS) production. This oxidative inflicts damage on DNA, proteins, lipids, accelerating telomere shortening, dysregulating autophagy, ultimately epigenetic age acceleration. For instance, exposure polycyclic aromatic hydrocarbons, benzene, pesticides has been associated with increased DNA methylation age. Early-life factors such as tobacco alcohol consumption further contribute accelerated The cumulative loss of healthy life years caused these can conceivably reach between 5 10 per person. Addressing pollutant-induced aging through regulatory measures, changes, therapeutic interventions essential mitigate their detrimental impacts, extending healthspan improving quality in populations.

Language: Английский

Citations

0
Do We Understand Heredity and Evolution? No DOI Creative Commons
Keith Baverstock

Published: April 1, 2025

Genetics has been the cornerstone for understanding life over a century, how it reproduces and evolves, human health is sustained. Johannsen’s 1911 genotype conception, that ‘genes are units of heredity,’ replaced phenotype conception upon which Galton’s successful 1897 law ancestral heredity was based[1]. However, case far from being closed. In 1992, radiation-induced genomic instability bystander effect challenged conception[2]. Further, in 2009, genetic variance could not explain fitness trajectory _E. coli_ bacteria Long-Term Evolution Experiment (LTEE)[3]. 2013, clear evolution LTEE thermodynamically, genetically, driven[4]. This paper briefly outlines history 1880 Mendelism 1900 reviews recent empirical evidence fundamentally challenges those two domains. Although past century genetics moved on to encompass such disciplines as epigenetic inheritance, regulatory networks, system biology, etc., 20th gene-centric concepts remain foundational.

Language: Английский

Citations

0
The Hormetic Adaptative Capacity and Resilience to Oxidative Stress Is Strengthened by Exposome Enrichment with Air Cold Atmospheric Plasma: A Metabolome Targeted Follow-Up Approach DOI Creative Commons
Lucía González-Llorente, Miguel Ángel Andrés Gasco, Miguel Aranda

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 949 - 949

Published: April 12, 2025

Background/Objectives: The exposome, encompassing all environmental influences on health, plays a pivotal role in oxidative stress-related diseases. Negative air ions (NAIs), generated via cold atmospheric plasma (CAP), have been proposed as potential modulators of resilience. This study aims to investigate the metabolic adaptations induced by prolonged exposure an NAI-enriched environment mice, focusing its effects stress markers and energy metabolism liver blood. Methods: Twenty male C57BL/6J mice were divided into four groups: two experimental groups exposed Air Cold Atmospheric Plasma–Nanoparticle Removal (aCAP-NR) device for either 18 days (short-term, ST) or 28 (long-term, LT), control without exposure. Targeted metabolomics was performed whole blood using ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS). Statistical pathway analyses conducted assess alterations. Results: Metabolic profiling revealed significant shifts pathways, including enhanced glutathione metabolism, reduced lipid peroxidation, modulation purine metabolism. Short-term led increased mitochondrial efficiency homeostasis, while long-term adaptive reprogramming, with higher inosine levels suggesting antioxidant anti-inflammatory responses. No adverse systemic hepatic health observed. Conclusions: NAI aCAP-NR elicits hormetic response, enhancing resilience stress. These findings suggest that controlled enrichment NAIs may serve novel non-invasive strategy mitigating damage improving adaptative capacity stress, warranting further translational research.

Language: Английский

Citations

0
Heritability of human lifespan is about 50% when confounding factors are addressed DOI Creative Commons
Ben Shenhar, Glen Pridham, Thaís Lopes De Oliveira

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract The heritability of human lifespan is a fundamental question in biology. Current estimates are low - twin studies show that about 20-25% the variation explained by genetics, and some large family pedigree suggest it as 7%. However, these do not distinguish between deaths driven intrinsic biological processes caused extrinsic factors such accidents or infections. Here we use mathematical modeling analyses cohorts raised together apart to mortality skews driving down measured correlations among pairs. We also identify nonlinear effect cutoff age—the minimum age death included each study — on heritability. Correcting for more than doubles previous estimates, revealing above 50%. Such high similar most other complex traits. thus challenge consensus genetics has only minor genes explain majority variation. Since important, understanding longevity can reveal aging mechanisms inform medicine public health.

Language: Английский

Citations

0
Implementation of genetic tests for disease prevention: challenges in evidence synthesis across clinical utility domains DOI Creative Commons
Angelica Valz Gris, Astrid M. Vicente, Stefania Boccia

et al.

European Journal of Public Health, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

Citations

0
Modifiable factors affects cancer-specific survival: findings from a large population-based prospective cohort study DOI Creative Commons

Chen Xiong,

Dongxi Zhu,

Chenchen Li

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 29, 2025

Language: Английский

Citations

0
Advancing translational exposomics: bridging genome, exposome and personalized medicine DOI Creative Commons
Dimosthenis Sarigiannis,

Spyros Karakitsios,

Ourania Anesti

et al.

Human Genomics, Journal Year: 2025, Volume and Issue: 19(1)

Published: April 30, 2025

Understanding the interplay between genetic predisposition and environmental lifestyle exposures is essential for advancing precision medicine public health. The exposome, defined as sum of all an individual encounters throughout their lifetime, complements genomic data by elucidating how external internal exposure factors influence health outcomes. This treatise highlights emerging discipline translational exposomics that integrates genomics, offering a comprehensive approach to decipher complex relationships exposures, variability, disease phenotypes. We highlight cutting-edge methodologies, including multi-omics technologies, exposome-wide association studies (EWAS), physiology-based biokinetic modeling, advanced bioinformatics approaches. These tools enable precise characterization both facilitating identification biomarkers, exposure-response relationships, prediction mechanisms. also consider importance addressing socio-economic, demographic, gender disparities in research. emphasize exposome can contextualize variation enhance causal inference, especially vulnerable populations diseases. By showcasing concrete examples proposing integrative platforms exposomics, this work underscores critical need bridge genomics prevention, risk stratification, decision-making. offers new paradigm understanding beyond genetics alone.

Language: Английский

Citations

0