Scientific Reports,
Journal Year:
2019,
Volume and Issue:
9(1)
Published: May 29, 2019
Abstract
The
integrity
of
cellular
membranes
is
critical
for
the
functionality
axons.
Failure
axonal
(plasma
membrane
and/or
myelin
sheath)
can
be
origin
neurological
diseases.
two
differ
in
content
sphingomyelin
and
galactosylceramide
lipids.
We
investigate
relation
between
lipid
bilayer
structural-mechanical
properties,
to
better
understand
dependency
properties
on
composition.
A
sphingomyelin/phospholipid/cholesterol
used
mimic
a
plasma
galactosylceramide/phospholipid/cholesterol
sheath.
Molecular
dynamics
simulations
are
performed
at
atomistic
coarse-grained
levels
characterize
bilayers
equilibrium
under
deformation.
For
comparison,
phospholipid
phospholipid/cholesterol
also
performed.
results
clearly
show
that
biomechanical
structural
features
depend
composition,
independent
molecular
models.
Both
or
lipids
increase
order
aliphatic
tails
resistance
water
penetration.
Having
30%
increases
stiffness.
Galactosylceramide
pack
together
via
sugar-sugar
interactions
hydrogen-bond
phosphocholine
with
correlated
thickness.
Our
findings
provide
insight
role
natural
membranes.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(16), P. 5850 - 5884
Published: Jan. 1, 2020
This
review
provides
an
introduction
to
the
state-of-the-art
force
microscope
methods
map
at
high-spatial
resolution
elastic
and
viscoelastic
properties
of
proteins,
polymers
cells.
Physiological Reviews,
Journal Year:
2019,
Volume and Issue:
100(2), P. 695 - 724
Published: Nov. 21, 2019
Physical
stimuli
are
essential
for
the
function
of
eukaryotic
cells,
and
changes
in
physical
signals
important
elements
normal
tissue
development
as
well
disease
initiation
progression.
The
complexity
cellular
they
initiate
complex
those
triggered
by
chemical
signals.
One
most
important,
focus
this
review,
is
effect
substrate
mechanical
properties
on
cell
structure
function.
past
decade
has
produced
a
nearly
exponentially
increasing
number
mechanobiological
studies
to
define
how
stiffness
alters
biology
using
both
purified
systems
intact
tissues.
Here
we
attempt
identify
common
features
mechanosensing
different
while
also
highlighting
numerous
informative
exceptions
what
early
appeared
be
simple
rules
which
cells
respond
stresses.
Advanced Materials,
Journal Year:
2019,
Volume and Issue:
31(19)
Published: March 25, 2019
Connective
tissue
is
one
of
the
four
major
types
animal
and
plays
essential
roles
throughout
human
body.
Genetic
factors,
aging,
trauma
all
contribute
to
connective
dysfunction
motivate
need
for
strategies
promote
healing
regeneration.
The
goal
here
link
a
fundamental
understanding
tissues
their
multiscale
properties
better
inform
design
translation
novel
biomaterials
Major
clinical
problems
in
adipose
tissue,
cartilage,
dermis,
tendon
are
discussed
that
inspire
replace
native
with
biomaterials.
Then,
structure-function
relationships
soft
may
be
used
guide
material
detailed.
Several
improve
these
incorporate
biologics
biologic-free
reviewed.
Finally,
important
guidance
documents
standards
(ASTM,
FDA,
EMA)
consider
translating
new
into
practice
highligted.
Chemical Reviews,
Journal Year:
2020,
Volume and Issue:
121(19), P. 11701 - 11725
Published: Nov. 9, 2020
During
the
last
three
decades,
a
series
of
key
technological
improvements
turned
atomic
force
microscopy
(AFM)
into
nanoscopic
laboratory
to
directly
observe
and
chemically
characterize
molecular
cell
biological
systems
under
physiological
conditions.
Here,
we
review
that
have
established
AFM
as
an
analytical
tool
quantify
native
from
micro-
nanoscale.
Native
include
living
tissues,
cells,
cellular
components
such
single
or
complexed
proteins,
nucleic
acids,
lipids,
sugars.
We
showcase
procedures
customize
chemical
laboratories
by
functionalizing
tips
outline
advantages
limitations
in
applying
different
modes
image,
sense,
manipulate
biosystems
at
(sub)nanometer
spatial
millisecond
temporal
resolution.
further
discuss
theoretical
approaches
extract
kinetic
thermodynamic
parameters
specific
biomolecular
interactions
detected
for
bonds
extend
discussion
multiple
bonds.
Finally,
highlight
potential
combining
with
optical
spectroscopy
address
full
complexity
tackle
fundamental
challenges
life
sciences.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(8), P. 2273 - 2290
Published: Jan. 1, 2020
Modulating
nanomedicine
mechanical
properties
for
enhanced
drug
delivery
to
tumors
has
attracted
increasing
attention
in
the
past
few
decades.
In
this
tutorial
review,
we
analyze
impact
of
on
vivo
transport
processes
and
highlight
most
recent
advances
efficiency
antitumor
efficacy.
Typical
nanoparticles
that
have
been
explored
purpose
since
2000
are
summarized
while
methods
tune
techniques
characterize
introduced.
end,
challenges
perspectives
tailoring
tumor
targeting
discussed.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(8), P. 11516 - 11544
Published: Aug. 2, 2022
Quantitative
phase
imaging
(QPI)
is
a
label-free,
wide-field
microscopy
approach
with
significant
opportunities
for
biomedical
applications.
QPI
uses
the
natural
shift
of
light
as
it
passes
through
transparent
object,
such
mammalian
cell,
to
quantify
biomass
distribution
and
spatial
temporal
changes
in
biomass.
Reported
cell
studies
more
than
60
years
ago,
ongoing
advances
hardware
software
are
leading
numerous
applications
biology,
dramatic
expansion
utility
over
past
two
decades.
Today,
investigations
size,
morphology,
behavior,
cellular
viscoelasticity,
drug
efficacy,
accumulation
turnover,
transport
mechanics
supporting
development,
physiology,
neural
activity,
cancer,
additional
physiological
processes
diseases.
Here,
we
review
field
biology
starting
underlying
principles,
followed
by
discussion
technical
approaches
currently
available
or
being
developed,
end
an
examination
breadth
use
under
development.
We
comment
on
strengths
shortcomings
deployment
key
contexts
conclude
emerging
challenges
based
combining
other
methodologies
that
expand
scope
even
further.
