ACS Photonics,
Journal Year:
2022,
Volume and Issue:
9(10), P. 3215 - 3224
Published: Sept. 27, 2022
Spatiotemporal
electron-beam
shaping
is
a
bold
frontier
of
electron
microscopy.
Over
the
past
decade,
methods
evolved
from
static
phase
plates
to
low-speed
electrostatic
and
magnetostatic
displays.
Recently,
swift
change
paradigm
utilizing
light
control
free
electrons
has
emerged.
Here,
we
experimentally
demonstrate
arbitrary
transverse
modulation
beams
without
complicated
electron-optics
elements
or
material
nanostructures,
but
rather
using
shaped
beams.
On-demand
spatial
wavepackets
obtained
via
inelastic
interaction
with
transversely
ultrafast
fields
controlled
by
an
external
modulator.
We
illustrate
this
method
for
cases
Hermite-Gaussian
Laguerre-Gaussian
discuss
their
use
in
enhancing
microscope
sensitivity.
Our
approach
dramatically
widens
range
patterns
that
can
be
imprinted
on
profile
greatly
facilitates
tailored
shaping.
FEBS Letters,
Journal Year:
2020,
Volume and Issue:
594(20), P. 3243 - 3261
Published: Oct. 1, 2020
Structural
biologists
have
traditionally
approached
cellular
complexity
in
a
reductionist
manner
which
the
molecular
components
are
fractionated
and
purified
before
being
studied
individually.
This
‘divide
conquer’
approach
has
been
highly
successful.
However,
awareness
grown
recent
years
that
biological
functions
can
rarely
be
attributed
to
individual
macromolecules.
Most
arise
from
their
concerted
action,
there
is
thus
need
for
methods
enabling
structural
studies
performed
situ
,
ideally
unperturbed
environments.
Cryo‐electron
tomography
(Cryo‐ET)
combines
power
of
3D
molecular‐level
imaging
with
best
preservation
physically
possible
achieve.
Thus,
it
unique
potential
reveal
supramolecular
architecture
or
‘molecular
sociology’
cells
discover
unexpected.
Here,
we
review
state‐of‐the‐art
Cryo‐ET
workflows,
provide
examples
applications,
discuss
what
needed
realize
full
Cryo‐ET.
Science,
Journal Year:
2021,
Volume and Issue:
371(6527), P. 371 - 374
Published: Jan. 21, 2021
Understanding
microscopic
processes
in
materials
and
devices
that
can
be
switched
by
light
requires
experimental
access
to
dynamics
on
nanometer
length
femtosecond
time
scales.
Here,
we
introduce
ultrafast
dark-field
electron
microscopy,
tailored
map
the
order
parameter
across
a
structural
phase
transition.
We
track
evolution
of
charge-density
wave
domains
1T-TaS2
after
ultrashort
laser
excitation,
elucidating
relaxation
pathways
domain
wall
dynamics.
The
unique
benefits
selective
contrast
enhancement
will
inspire
future
beam
shaping
technology
transmission
microscopy.
ACS Photonics,
Journal Year:
2021,
Volume and Issue:
8(4), P. 945 - 974
Published: March 25, 2021
Free
electron
beams
such
as
those
employed
in
microscopes
have
evolved
into
powerful
tools
to
investigate
photonic
nanostructures
with
an
unrivaled
combination
of
spatial
and
spectral
precision
through
the
analysis
energy
losses
cathodoluminescence
light
emission.
In
ultrafast
optics,
emerging
field
microscopy
utilizes
synchronized
femtosecond
pulses
that
are
aimed
at
sampled
structures,
holding
promise
bring
simultaneous
sub-Å-sub-fs-sub-meV
space-time-energy
resolution
study
material
optical-field
dynamics.
addition,
these
advances
enable
manipulation
wave
function
individual
free
electrons
unprecedented
ways,
opening
sound
prospects
probe
control
quantum
excitations
nanoscale.
Here,
we
provide
overview
photonics
research
based
on
electrons,
supplemented
by
original
theoretical
insights
discussion
several
stimulating
challenges
opportunities.
particular,
show
excitation
probability
a
single
is
independent
its
function,
apart
from
classical
average
over
transverse
beam
density
profile,
whereas
for
two
or
more
modulated
depends
their
relative
arrangement,
thus
reflecting
nature
interactions.
We
derive
first-principles
analytical
expressions
embody
results
general
validity
arbitrarily
shaped
any
type
electron-sample
interaction.
conclude
some
perspectives
various
exciting
directions
include
disruptive
approaches
noninvasive
spectroscopy
microscopy,
possibility
sampling
nonlinear
optical
response
nanoscale,
matrices
associated
sample
modes,
appealing
applications
modulation
beams,
all
which
could
potentially
revolutionize
use
photonics.
Science,
Journal Year:
2021,
Volume and Issue:
373(6561)
Published: Aug. 26, 2021
The
fundamental
interaction
between
free
electrons
and
light
stands
at
the
base
of
both
classical
quantum
physics,
with
applications
in
free-electron
acceleration,
radiation
sources,
electron
microscopy.
Yet,
to
this
day,
all
experiments
involving
interactions
are
fully
explained
by
describing
as
a
wave,
disregarding
its
nature.
Here,
we
observe
statistics
effects
photons
on
free-electron-light
interactions.
We
demonstrate
passing
continuously
from
Poissonian
super-Poissonian
up
thermal
statistics,
unveiling
surprising
manifestation
Bohr's
Correspondence
Principle:
transition
walk
random
energy
ladder.
walker
serves
probe
non-destructive
detection,
measuring
photon-correlation
${g^{(2)}
(0)}$
higher-orders
${g^{(n)}
(0)}$.
Unlike
conventional
quantum-optical
detectors,
can
perform
weak
measurements
projective
evolving
into
an
entangled
joint-state
photons.
Our
findings
suggest
free-electron-based
tomography
light,
constitute
important
step
towards
combined
attosecond-temporal
sub-A-spatial
resolution
Annual Review of Biophysics,
Journal Year:
2023,
Volume and Issue:
52(1), P. 573 - 595
Published: May 9, 2023
Recent
advances
in
cryo-electron
microscopy
have
marked
only
the
beginning
of
potential
this
technique.
To
bring
structure
into
cell
biology,
modality
tomography
has
fast
developed
a
bona
fide
situ
structural
biology
technique
where
structures
are
determined
their
native
environment,
cell.
Nearly
every
step
cryo-focused
ion
beam-assisted
electron
(cryo-FIB-ET)
workflow
been
improved
upon
past
decade,
since
first
windows
were
carved
cells,
unveiling
macromolecular
networks
near-native
conditions.
By
bridging
and
cryo-FIB-ET
is
advancing
our
understanding
structure–function
relationships
environment
becoming
tool
for
discovering
new
biology.
Journal of Optics,
Journal Year:
2023,
Volume and Issue:
25(10), P. 103001 - 103001
Published: July 26, 2023
Abstract
Structured
waves
are
ubiquitous
for
all
areas
of
wave
physics,
both
classical
and
quantum,
where
the
wavefields
inhomogeneous
cannot
be
approximated
by
a
single
plane
wave.
Even
interference
two
waves,
or
(evanescent)
wave,
provides
number
nontrivial
phenomena
additional
functionalities
as
compared
to
Complex
with
inhomogeneities
in
amplitude,
phase,
polarization,
including
topological
structures
singularities,
underpin
modern
nanooptics
photonics,
yet
they
equally
important,
e.g.
quantum
matter
acoustics,
water
etc.
crucial
optical
electron
microscopy,
propagation
scattering,
imaging,
communications,
optics,
non-Hermitian
systems,
condensed-matter
optomechanics,
plasmonics
metamaterials,
acoustic
manipulation,
so
forth.
This
Roadmap
is
written
collectively
prominent
researchers
aims
survey
role
structured
various
physics.
Providing
background,
current
research,
anticipating
future
developments,
it
will
interest
wide
cross-disciplinary
audience.
