Muscle cell‐derived cytokines in skeletal muscle regeneration DOI
Rachel J. Waldemer, Dong‐Wook Kim, Jie Chen

et al.

FEBS Journal, Journal Year: 2022, Volume and Issue: 289(21), P. 6463 - 6483

Published: Jan. 24, 2022

Regeneration of the mammalian adult skeletal muscle is a well‐orchestrated process regulated by multiple proteins and signalling pathways. Cytokines constitute major class regulators myogenesis. It well established that infiltrating immune cells at site injury secrete cytokines, which play critical roles in myofibre repair regeneration process. In past 10–15 years, itself has emerged as prolific producer cytokines. Much attention field been focused on endocrine effects muscle‐secreted cytokines (myokines) metabolic regulation. However, ample evidence suggests muscle‐derived also regulate myogenic differentiation an autocrine manner. this review, we survey meet two criteria: (a) expression cells; (b) demonstrating function. Dozens representing several classes make up group, together they all steps How such large array coordinate their to form regulatory network fascinating, pressing question. Functional studies can distinguish source vivo are much needed order facilitate exploration full therapeutic potential.

Language: Английский

CRISPR/Cas-Based Epigenome Editing: Advances, Applications, and Clinical Utility DOI
Jacob Goell, Isaac B. Hilton

Trends in biotechnology, Journal Year: 2021, Volume and Issue: 39(7), P. 678 - 691

Published: May 7, 2021

Language: Английский

Citations

83
ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression DOI Creative Commons
Ni Li, Qiuli Liu, Ying Han

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 26, 2022

Abstract Chronic inflammation and an immunosuppressive microenvironment promote prostate cancer (PCa) progression diminish the response to immune checkpoint blockade (ICB) therapies. However, it remains unclear how what extent these two events are coordinated. Here, we show that ARID1A, a subunit of SWI/SNF chromatin remodeling complex, functions downstream inflammation-induced IKKβ activation shape tumor (TME). Prostate-specific deletion Arid1a cooperates with Pten loss accelerate tumorigenesis. We identify polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) as major infiltrating cell type causes evasion reveal neutralization PMN-MDSCs restricts -deficient tumors. Mechanistically, inflammatory cues activate phosphorylate leading its degradation via β-TRCP. ARID1A downregulation in turn silences enhancer A20 deubiquitinase, critical negative regulator NF-κB signaling, thereby unleashes CXCR2 ligand-mediated MDSC chemotaxis. Importantly, our results support therapeutic strategy anti-NF-κB antibody or targeting combined ICB for advanced PCa. Together, findings highlight IKKβ/ARID1A/NF-κB feedback axis integrates immunosuppression PCa progression.

Language: Английский

Citations

59
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons DOI

Jessica Giehrl‐Schwab,

Florian Giesert, Benedict Rauser

et al.

EMBO Molecular Medicine, Journal Year: 2022, Volume and Issue: 14(5)

Published: April 4, 2022

Language: Английский

Citations

53
CRISPR screens for functional interrogation of immunity DOI
Hao Shi, John G. Doench, Hongbo Chi

et al.

Nature reviews. Immunology, Journal Year: 2022, Volume and Issue: 23(6), P. 363 - 380

Published: Dec. 8, 2022

Language: Английский

Citations

53
Muscle cell‐derived cytokines in skeletal muscle regeneration DOI
Rachel J. Waldemer, Dong‐Wook Kim, Jie Chen

et al.

FEBS Journal, Journal Year: 2022, Volume and Issue: 289(21), P. 6463 - 6483

Published: Jan. 24, 2022

Regeneration of the mammalian adult skeletal muscle is a well‐orchestrated process regulated by multiple proteins and signalling pathways. Cytokines constitute major class regulators myogenesis. It well established that infiltrating immune cells at site injury secrete cytokines, which play critical roles in myofibre repair regeneration process. In past 10–15 years, itself has emerged as prolific producer cytokines. Much attention field been focused on endocrine effects muscle‐secreted cytokines (myokines) metabolic regulation. However, ample evidence suggests muscle‐derived also regulate myogenic differentiation an autocrine manner. this review, we survey meet two criteria: (a) expression cells; (b) demonstrating function. Dozens representing several classes make up group, together they all steps How such large array coordinate their to form regulatory network fascinating, pressing question. Functional studies can distinguish source vivo are much needed order facilitate exploration full therapeutic potential.

Language: Английский

Citations

42