Alzheimer disease

Nature Reviews Disease Primers, Journal Year: 2021, Volume and Issue: 7(1)

Published: May 13, 2021

Language: Английский

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The gut microbiota–brain axis in behaviour and brain disorders

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(4), P. 241 - 255

Published: Oct. 22, 2020

Language: Английский

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Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo

Neuron, Journal Year: 2019, Volume and Issue: 103(6), P. 1016 - 1033.e10

Published: July 30, 2019

Language: Английский

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Immune Signaling in Neurodegeneration

Immunity, Journal Year: 2019, Volume and Issue: 50(4), P. 955 - 974

Published: April 1, 2019

Language: Английский

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Microglia: Agents of the CNS Pro-Inflammatory Response

Cells, Journal Year: 2020, Volume and Issue: 9(7), P. 1717 - 1717

Published: July 17, 2020

The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative diseases. Though research spans over century, last two decades have increased our understanding exponentially. Here, we discuss phenotypic transformation from homeostatic towards reactive microglia, initiated specific ligand binding pattern recognition receptors including toll-like receptor-4 (TLR4) or triggering expressed on myeloid cells-2 (TREM2), as well signaling pathways triggered such caspase-mediated response. Additionally, new disciplines epigenetics and immunometabolism provided us with more holistic view how changes in DNA methylation, microRNAs, metabolome may influence This review aimed current knowledge different angles, recent highlights role exosomes spreading neuroinflammation emerging techniques positron emission tomography (PET) scanning use human generated induced pluripotent stem cells (iPSCs). Finally, also thoughts impact

Language: Английский

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The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

Molecules, Journal Year: 2018, Volume and Issue: 23(12), P. 3283 - 3283

Published: Dec. 11, 2018

Neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease and Huntington’s present a major health issue financial burden for care systems around the world. The impact of these diseases will further increase over next decades due to increasing life expectancies. No cure is currently available treatment conditions; only drugs, which merely alleviate symptoms. Oxidative stress has long been associated with neurodegeneration, whether as cause or part downstream results caused by other factors. Thus, use antioxidants counter cellular oxidative within nervous system suggested potential option neurological disorders. Over last decade, significant research focused on natural target stress. However, clinical trial have lacked success patients knowledge that extracts show positive molecular activities in addition antioxidant activity, however, led their prevention treatment/management neurodegenerative diseases. This review cover several vitro vivo studies, well trials, highlight antioxidants.

Language: Английский

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Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases

Journal of Clinical Investigation, Journal Year: 2019, Volume and Issue: 129(10), P. 4539 - 4549

Published: Sept. 15, 2019

Parkinson's disease (PD) is a common neurodegenerative that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP levels are features of PD. Previous studies revealed terazosin (TZ) enhances the activity phosphoglycerate kinase 1 (PGK1), thereby stimulating glycolysis increasing cellular levels. Therefore, we asked whether enhancement PGK1 would change course In toxin-induced genetic PD models in mice, rats, flies, induced pluripotent stem cells, TZ increased brain slowed or prevented neuron loss. The drug dopamine partially restored motor function. Because prescribed clinically, also interrogated 2 distinct human databases. We found slower progression, decreased PD-related complications, frequency diagnoses individuals taking related drugs. These findings suggest enhancing may slow neurodegeneration

Language: Английский

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Neuroinflammation in frontotemporal dementia

Nature Reviews Neurology, Journal Year: 2019, Volume and Issue: 15(9), P. 540 - 555

Published: July 19, 2019

Language: Английский

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The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 6, 2022

Alzheimer’s disease (AD) is a devastating age-related neurodegenerative disorder with an alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of which therapeutic effect not yet conclusively proven, only symptomatic medication that effective some AD patients available. In order to be able design more rational and treatments, our understanding mechanisms behind pathogenesis progression urgently needs improved. Over last years, it became increasingly clear peripheral inflammation one detrimental factors can contribute disease. Here, we discuss current how systemic intestinal (referred as gut-brain axis) inflammatory processes may affect brain pathology, specific focus on AD. Moreover, give comprehensive overview different preclinical well clinical studies link Inflammation initiation progression. Altogether, this review broadens pathology help in further research aiming identify novel targets.

Language: Английский

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Identification of neural oscillations and epileptiform changes in human brain organoids

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(10), P. 1488 - 1500

Published: Aug. 23, 2021

Language: Английский

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