Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review

Pharmacological Reviews, Journal Year: 2022, Volume and Issue: 74(1), P. 119 - 140

Published: Jan. 1, 2022

A widely held dogma in the preclinical addiction field is that females are more vulnerable than males to drug craving and relapse. Here, we first review clinical studies on sex differences psychostimulant opioid Next, reinstatement of seeking after extinction self-administration, incubation (time-dependent increase during abstinence). We also discuss ovarian hormones' role relapse humans animal models speculate brain mechanisms underlying their cocaine rodent models. Finally, imaging responses cues stress men women.The results reviewed do not appear support notion women However, this conclusion tentative because most were correlational, sufficiently powered, a priori designed detect differences. Additionally, suggest stress. The provide evidence for stress-induced but cue- or cocaine-induced seeking. These modulated part by hormones. In contrast, available data relapse/reinstatement methamphetamine opioids

Significance Statement

This systematic summarizes Results

Language: Английский

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Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need

Science, Journal Year: 2024, Volume and Issue: 384(6693)

Published: April 18, 2024

Drugs of abuse are thought to promote addiction in part by “hijacking” brain reward systems, but the underlying mechanisms remain undefined. Using whole-brain FOS mapping and vivo single-neuron calcium imaging, we found that drugs augment dopaminoceptive ensemble activity nucleus accumbens (NAc) disorganize overlapping responses natural rewards a cell type–specific manner. Combining FOS-Seq, CRISPR-perturbation, single-nucleus RNA sequencing, identified Rheb as molecular substrate regulates signal transduction NAc while enabling suppress consumption. Mapping NAc-projecting regions activated revealed input-specific effects on These findings characterize dynamic, circuit basis common pathway, wherein interfere with fulfillment innate needs.

Language: Английский

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A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens

Frontiers in Neuroendocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 101175 - 101175

Published: Jan. 1, 2025

Language: Английский

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Incubation of Cocaine Craving After Intermittent-Access Self-administration: Sex Differences and Estrous Cycle

Biological Psychiatry, Journal Year: 2019, Volume and Issue: 85(11), P. 915 - 924

Published: Jan. 30, 2019

Background Studies using continuous-access drug self-administration showed that cocaine seeking increases during abstinence (incubation of craving). Recently, studies intermittent-access increased motivation to self-administer and seek cocaine. We examined whether intermittent would potentiate incubation craving in male female rats the estrous cycle's role this incubation. Methods In experiment 1, self-administered either continuously (8 hours/day) or intermittently (5 minutes ON, 25 OFF × 16) for 12 days, followed by relapse tests after 2 29 days. experiments 3, six, 12, 18 sessions. 4, 3 cycle was measured a vaginal smear test. Results Incubation observed both sexes continuous self-administration. Independent access condition day, higher than rats. sexes, on days access. rats, significantly estrus non-estrus; access, effect independent training duration. Conclusions caused time-independent abstinence. time-dependent increase (incubation) is critically dependent phase.

Language: Английский

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Personalizing the Treatment of Substance Use Disorders

American Journal of Psychiatry, Journal Year: 2020, Volume and Issue: 177(2), P. 113 - 116

Published: Feb. 1, 2020

Language: Английский

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Relapse to opioid seeking in rat models: behavior, pharmacology and circuits

Neuropsychopharmacology, Journal Year: 2018, Volume and Issue: 44(3), P. 465 - 477

Published: Oct. 6, 2018

Language: Английский

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Operant Social Reward Decreases Incubation of Heroin Craving in Male and Female Rats

Biological Psychiatry, Journal Year: 2019, Volume and Issue: 86(11), P. 848 - 856

Published: May 30, 2019

Language: Английский

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Economics for the future – Beyond the superorganism

Ecological Economics, Journal Year: 2019, Volume and Issue: 169, P. 106520 - 106520

Published: Nov. 20, 2019

Our environment and economy are at a crossroads. This paper attempts cohesive narrative on how human evolved behavior, money, energy, the fit together. Humans strive for same emotional state of our successful ancestors. In resource rich environment, we coordinate in groups, corporations nations, to maximize financial surplus, tethered carbon. At global scales, emergent result this combination is mindless, energy hungry, CO2 emitting Superorganism. Under dynamic now behaviorally ‘growth constrained’ will use any means possible avoid facing reality. The farther kick can, larger disconnect between physical reality becomes. moment recalibration be watershed time culture, but could also birth new ‘systems economics’. resultant different ways living. next 30 years apply all we’ve learned during past years. We’ve arrived species level conversation.

Language: Английский

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The role of stress in drug addiction. An integrative review

Physiology & Behavior, Journal Year: 2019, Volume and Issue: 202, P. 62 - 68

Published: Jan. 31, 2019

Language: Английский

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Nucleus Accumbens Drd1-Expressing Neurons Control Aggression Self-Administration and Aggression Seeking in Mice

Journal of Neuroscience, Journal Year: 2019, Volume and Issue: 39(13), P. 2482 - 2496

Published: Jan. 17, 2019

We recently developed a mouse model of appetitive operant aggression and reported that adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate relapse seeking during abstinence. Here we studied role nucleus accumbens (NAc) dopamine receptor (Drd)1- Drd2-expressing neurons in self-administration seeking. trained self-administer intruders (9 d, 12 trials/d) tested them on abstinence Day 1. used immunohistochemistry in situ hybridization measure neuronal activity marker Fos NAc, cell-type-specific colocalization with Drd1- neurons. To test causal neurons, validated transgenic hybrid breeding strategy crossing inbred Drd1-Cre Drd2-Cre Cre-DREADD (hM4Di) inhibit NAc neuron activity. found induced higher expression shell than core, Fos colocalized Drd1 Drd2 both subregions, chemogenetic inhibition Drd1-, but not Drd2-, expressing decreased Results indicate Drd1-expressing is critical Our study also validates simple between C57-based Cre lines can be cell-type circuit mechanisms reward relapse. SIGNIFICANCE STATEMENT Aggression often comorbid neuropsychiatric diseases, including drug addiction. One form, aggression, exhibits symptomatology mimics addiction hypothesized due dysregulation addiction-related circuits. However, our mechanistic understanding circuitry modulating limited. novel relapse, combination immunohistochemistry, hybridization, manipulations examine how cell types are recruited for, control, one population, 1-expressing act as modulator

Language: Английский

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