Science Translational Medicine,
Journal Year:
2019,
Volume and Issue:
11(487)
Published: April 10, 2019
After
a
spinal
cord
injury,
axons
fail
to
regenerate
in
the
adult
mammalian
central
nervous
system,
leading
permanent
deficits
sensory
and
motor
functions.
Increasing
neuronal
activity
after
an
injury
using
electrical
stimulation
or
rehabilitation
can
enhance
plasticity
result
some
degree
of
recovery;
however,
underlying
mechanisms
remain
poorly
understood.
We
found
that
placing
mice
enriched
environment
before
enhanced
proprioceptive
dorsal
root
ganglion
neurons,
lasting
increase
their
regenerative
potential.
This
effect
was
dependent
on
Creb-binding
protein
(Cbp)-mediated
histone
acetylation,
which
increased
expression
genes
associated
with
program.
Intraperitoneal
delivery
small-molecule
activator
Cbp
at
clinically
relevant
times
promoted
regeneration
sprouting
axons,
as
well
recovery
functions
both
mouse
rat
model
injury.
Our
findings
showed
capacity
induced
by
enhancing
is
mediated
epigenetic
reprogramming
rodent
models
Understanding
activity-dependent
led
identification
potential
molecular
targets
for
improving
