Proceedings of the National Academy of Sciences,
Journal Year:
2023,
Volume and Issue:
120(46)
Published: Nov. 8, 2023
Understanding
the
neurobiological
mechanisms
underlying
consciousness
remains
a
significant
challenge.
Recent
evidence
suggests
that
coupling
between
distal–apical
and
basal–somatic
dendrites
in
thick-tufted
layer
5
pyramidal
neurons
(L5
PN
),
regulated
by
nonspecific-projecting
thalamus,
is
crucial
for
consciousness.
Yet,
it
uncertain
whether
this
thalamocortical
mechanism
can
support
emergent
signatures
of
consciousness,
such
as
integrated
information.
To
address
question,
we
constructed
biophysical
network
dual-compartment
L5
,
with
dendrosomatic
controlled
thalamic
inputs.
Our
findings
demonstrate
information
maximized
when
nonspecific
inputs
drive
system
into
regime
time-varying
synchronous
bursting.
Here,
exhibits
variable
spiking
dynamics
broad
pairwise
correlations,
supporting
enhanced
Further,
observed
peak
aligns
criticality
empirically
bursting
rates.
These
results
suggest
core
mammalian
brain
may
be
evolutionarily
configured
to
optimize
effective
processing,
providing
potential
neuronal
integrates
microscale
theories
macroscale
IEEE Transactions on Emerging Topics in Computational Intelligence,
Journal Year:
2023,
Volume and Issue:
7(3), P. 818 - 828
Published: March 1, 2023
Context-sensitive
two-point
layer
5
pyramidal
cells
(L5PCs)
were
discovered
as
long
ago
1999.However,
the
potential
of
this
discovery
to
provide
useful
neural
computation
has
yet
be
demonstrated.Here
we
show
for
first
time
how
a
transformative
L5PCs-driven
deep
network
(DNN),
termed
multisensory
cooperative
computing
(MCC)
architecture,
can
effectively
process
large
amounts
heterogeneous
realworld
audio-visual
(AV)
data,
using
far
less
energy
compared
best
available
'point'
neuron-driven
DNNs.A
novel
highlydistributed
parallel
implementation
on
Xilinx
UltraScale+
MPSoC
device
estimates
savings
up
245759
×
50000
µJ
(i.e.,
62%
than
baseline
model
in
semi-supervised
learning
setup)
where
single
synapse
consumes
8e
-5
µJ.In
supervised
setup,
energy-saving
potentially
reach
1250x
(per
feedforward
transmission)
model.The
significantly
reduced
activity
MCC
leads
inherently
fast
and
resilience
against
sudden
damage.This
remarkable
performance
pilot
experiments
demonstrates
embodied
neuromorphic
intelligence
our
proposed
L5PC
that
receives
input
from
diverse
neighbouring
neurons
context
amplify
transmission
most
salient
relevant
information
onward
transmission,
overwhelmingly
multimodal
utilised
at
early
stages
on-chip
training.Our
approach
opens
new
cross-disciplinary
avenues
future
DNN
training
implementations
posits
radical
shift
current
paradigms.
Interface Focus,
Journal Year:
2023,
Volume and Issue:
13(3)
Published: April 14, 2023
How
is
the
massive
dimensionality
and
complexity
of
microscopic
constituents
nervous
system
brought
under
sufficiently
tight
control
so
as
to
coordinate
adaptive
behaviour?
A
powerful
means
for
striking
this
balance
poise
neurons
close
critical
point
a
phase
transition,
at
which
small
change
in
neuronal
excitability
can
manifest
nonlinear
augmentation
activity.
brain
could
mediate
transition
key
open
question
neuroscience.
Here,
I
propose
that
different
arms
ascending
arousal
provide
with
diverse
set
heterogeneous
parameters
be
used
modulate
receptivity
target
neurons-in
other
words,
act
mediating
order.
Through
series
worked
examples,
demonstrate
how
neuromodulatory
interact
inherent
topological
subsystems
complex
behaviour.
NeuroImage,
Journal Year:
2023,
Volume and Issue:
269, P. 119926 - 119926
Published: Feb. 3, 2023
High-level
brain
functions
are
widely
believed
to
emerge
from
the
orchestrated
activity
of
multiple
neural
systems.
However,
lacking
a
formal
definition
and
practical
quantification
emergence
for
experimental
data,
neuroscientists
have
been
unable
empirically
test
this
long-standing
conjecture.
Here
we
investigate
fundamental
question
by
leveraging
recently
proposed
framework
known
as
"Integrated
Information
Decomposition,"
which
establishes
principled
information-theoretic
approach
operationalise
quantify
in
dynamical
systems
-
including
human
brain.
By
analysing
functional
MRI
our
results
show
that
emergent
hierarchical
character
dynamics
is
significantly
diminished
chronically
unresponsive
patients
suffering
severe
injury.
At
level,
demonstrate
capacity
positively
correlated
with
extent
organisation
activity.
Furthermore,
combining
computational
approaches
network
control
theory
whole-brain
biophysical
modelling,
reduced
severely
brain-injured
can
be
mechanistically
explained
disruptions
patients'
structural
connectome.
Overall,
suggest
chronic
unresponsiveness
resulting
injury
may
related
impairment
infrastructures
required
support
emergence.
Proceedings of the National Academy of Sciences,
Journal Year:
2023,
Volume and Issue:
120(46)
Published: Nov. 8, 2023
Understanding
the
neurobiological
mechanisms
underlying
consciousness
remains
a
significant
challenge.
Recent
evidence
suggests
that
coupling
between
distal–apical
and
basal–somatic
dendrites
in
thick-tufted
layer
5
pyramidal
neurons
(L5
PN
),
regulated
by
nonspecific-projecting
thalamus,
is
crucial
for
consciousness.
Yet,
it
uncertain
whether
this
thalamocortical
mechanism
can
support
emergent
signatures
of
consciousness,
such
as
integrated
information.
To
address
question,
we
constructed
biophysical
network
dual-compartment
L5
,
with
dendrosomatic
controlled
thalamic
inputs.
Our
findings
demonstrate
information
maximized
when
nonspecific
inputs
drive
system
into
regime
time-varying
synchronous
bursting.
Here,
exhibits
variable
spiking
dynamics
broad
pairwise
correlations,
supporting
enhanced
Further,
observed
peak
aligns
criticality
empirically
bursting
rates.
These
results
suggest
core
mammalian
brain
may
be
evolutionarily
configured
to
optimize
effective
processing,
providing
potential
neuronal
integrates
microscale
theories
macroscale
