An operant social self-administration and choice model in mice

Nature Protocols, Journal Year: 2023, Volume and Issue: 18(6), P. 1669 - 1686

Published: March 24, 2023

Language: Английский

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Neural Control of Sexually Dimorphic Social Behavior: Connecting Development to Adulthood

Annual Review of Neuroscience, Journal Year: 2023, Volume and Issue: 46(1), P. 321 - 339

Published: March 31, 2023

Rapid advances in the neural control of social behavior highlight role interconnected nodes engaged differential information processing to generate behavior. Many innate behaviors are essential reproductive fitness and therefore fundamentally different males females. Programming these differences occurs early development mammals, following gonadal differentiation copious androgen production by fetal testis during a critical period. Early-life programming its adult manifestation separate but yoked processes, yet how they linked is unknown. This review seeks that gap identifying four core mechanisms (epigenetics, cell death, circuit formation, hormonal modulation) could connect developmental changes mating aggression. We further propose unique behavior, adolescent play, bridges preweaning postpubertal brain engaging same networks underpinning aggressive behaviors.

Language: Английский

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The Synaptic and Circuit Functions of Vitamin D in Neurodevelopment Disorders

Neuropsychiatric Disease and Treatment, Journal Year: 2023, Volume and Issue: Volume 19, P. 1515 - 1530

Published: July 1, 2023

Vitamin D deficiency/insufficiency is a public health issue around the world.According to epidemiological studies, low vitamin levels have been associated with an increased risk of some neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention-deficit hyperactivity (ADHD).Animal models reveal that has variety impacts on synapses circuits in brain.A lack affects expression synaptic proteins, as well synthesis metabolism various neurotransmitters.Depending where receptors (VDRs) are expressed, may also regulate certain neuronal through endocannabinoid signaling, mTOR pathway oxytocin signaling.While inconsistently, data suggest supplementation be able reduce core symptoms ASD ADHD.This review emphasizes D's role circuit mechanisms disorders ADHD.Future application these will depend both basic research clinical order make transition from bench bedside.

Language: Английский

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Characterizing the mechanisms of social connection

Neuron, Journal Year: 2023, Volume and Issue: 111(24), P. 3911 - 3925

Published: Oct. 6, 2023

Understanding how individuals form and maintain strong social networks has emerged as a significant public health priority result of the increased focus on epidemic loneliness myriad protective benefits conferred by connection. In this review, we highlight psychological neural mechanisms that enable us to connect with others, which in turn help buffer against consequences stress isolation. Central process is experience rewards derived from positive interactions, encourage sharing perspectives preferences unite individuals. Sharing affective states others helps align our understanding world another's, thereby continuing reinforce bonds strengthen relationships. These processes depend systems supporting reward cognitive function. Lastly, also consider limitations associated pursuing healthy connections outline potential avenues future research.

Language: Английский

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Advancing preclinical chronic stress models to promote therapeutic discovery for human stress disorders

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 49(1), P. 215 - 226

Published: June 22, 2023

Language: Английский

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