Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(9)
Published: Jan. 25, 2023
Abstract
Autonomic
imbalance
is
an
important
characteristic
of
patients
after
myocardial
infarction
(MI)
and
adversely
contributes
to
post‐MI
cardiac
remodeling
ventricular
arrhythmias
(VAs).
A
previous
study
proved
that
optogenetic
modulation
could
precisely
inhibit
sympathetic
hyperactivity
prevent
acute
ischemia‐induced
VAs.
Here,
a
wireless
self‐powered
system
introduced,
which
achieves
long‐term
precise
neuromodulation
in
ambulatory
canines.
The
optical
based
on
triboelectric
nanogenerator
powered
by
energy
harvested
from
body
motion
realized
the
effective
illumination
required
for
(ON).
It
further
demonstrated
ON
significantly
mitigates
MI‐induced
hyperactivity,
improves
variety
clinically
relevant
outcomes
such
as
dysfunction,
reduces
infarct
size,
increases
electrophysiological
stability,
susceptibility
These
novel
insights
suggest
holds
translational
potential
clinical
treatment
arrhythmia
other
cardiovascular
diseases
related
hyperactivity.
Moreover,
this
innovative
may
provide
opportunity
develop
implantable/wearable
self‐controllable
devices
therapy.
Neuron,
Journal Year:
2022,
Volume and Issue:
110(14), P. 2242 - 2257.e6
Published: May 27, 2022
Gene
therapy
offers
great
promise
in
addressing
neuropathologies
associated
with
the
central
and
peripheral
nervous
systems
(CNS
PNS).
However,
genetic
access
remains
difficult,
reflecting
critical
need
for
development
of
effective
non-invasive
gene
delivery
vectors
across
species.
To
that
end,
we
evolved
adeno-associated
virus
serotype
9
(AAV9)
capsid
mice
validated
two
capsids,
AAV-MaCPNS1
AAV-MaCPNS2,
rodent
species
(mice
rats)
non-human
primate
(NHP)
(marmosets
rhesus
macaques).
Intravenous
administration
either
AAV
efficiently
transduced
PNS
rodents
both
CNS
NHPs.
Furthermore,
used
to
systemically
deliver
following:
(1)
neuronal
sensor
jGCaMP8s
record
calcium
signal
dynamics
nodose
ganglia
(2)
actuator
DREADD
dorsal
root
mediate
pain.
This
conclusively
demonstrates
translatability
these
systemic
AAVs
four
their
functional
utility
through
proof-of-concept
studies
mice.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(30)
Published: Aug. 28, 2022
Abstract
Recently,
bioelectronic
devices
extensively
researched
and
developed
through
the
convergence
of
flexible
biocompatible
materials
electronics
design
that
enables
more
precise
diagnostics
therapeutics
in
human
health
care
opens
up
potential
to
expand
into
various
fields,
such
as
clinical
medicine
biomedical
research.
To
establish
an
accurate
stable
bidirectional
bio‐interface,
protection
against
external
environment
high
mechanical
deformation
is
essential
for
wearable
devices.
In
case
implantable
bioelectronics,
special
encapsulation
optimized
designs
configurations
provide
electronic
stability
functionality
are
required
accommodating
organ
properties,
lifespans,
functions
biofluid
environment.
Here,
this
study
introduces
recent
developments
ultra‐thin
encapsulations
with
novel
can
preserve
or
even
improve
electrical
performance
bio‐integrated
by
supporting
safety
from
destruction
contamination
well
optimizing
use
systems
physiological
environments.
addition,
a
summary
materials,
methods,
characteristics
most
widely
used
technologies
introduced,
thereby
providing
strategic
selection
appropriate
choices
recently
bioelectronics.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(32), P. 17497 - 17514
Published: Aug. 3, 2023
meso-methyl
BODIPY
photocages
have
recently
emerged
as
an
exciting
new
class
of
photoremovable
protecting
groups
(PPGs)
that
release
leaving
upon
absorption
visible
to
near-infrared
light.
In
this
Perspective,
we
summarize
the
development
these
PPGs
and
highlight
their
critical
photochemical
properties
applications.
We
discuss
PPGs,
structure–photoreactivity
studies,
insights
into
photoreaction
mechanism,
scope
functional
can
be
caged,
chemical
synthesis
structures,
how
substituents
alter
water
solubility
PPG
direct
specific
subcellular
compartments.
Applications
exploit
unique
optical
are
also
discussed,
from
wavelength-selective
photoactivation
biological
studies
photoresponsive
organic
materials
photomedicine.
Science Robotics,
Journal Year:
2023,
Volume and Issue:
8(74)
Published: Jan. 18, 2023
Bioengineering
approaches
that
combine
living
cellular
components
with
three-dimensional
scaffolds
to
generate
motion
can
be
used
develop
a
new
generation
of
miniature
robots.
Integrating
on-board
electronics
and
remote
control
in
these
biological
machines
will
enable
various
applications
across
engineering,
biology,
medicine.
Here,
we
present
hybrid
bioelectronic
robots
equipped
battery-free
microinorganic
light-emitting
diodes
for
wireless
real-time
communication.
Centimeter-scale
walking
were
computationally
designed
optimized
host
optoelectronics
independent
stimulation
multiple
optogenetic
skeletal
muscles,
achieving
command
walking,
turning,
plowing,
transport
functions
both
at
individual
collective
levels.
This
work
paves
the
way
toward
class
biohybrid
able
actuation
sensing
computing.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(3), P. 768 - 859
Published: Jan. 19, 2024
Optoelectronic
devices
with
unconventional
form
factors,
such
as
flexible
and
stretchable
light-emitting
or
photoresponsive
devices,
are
core
elements
for
the
next-generation
human-centric
optoelectronics.
For
instance,
these
deformable
can
be
utilized
closely
fitted
wearable
sensors
to
acquire
precise
biosignals
that
subsequently
uploaded
cloud
immediate
examination
diagnosis,
also
used
vision
systems
human-interactive
robotics.
Their
inception
was
propelled
by
breakthroughs
in
novel
optoelectronic
material
technologies
device
blueprinting
methodologies,
endowing
flexibility
mechanical
resilience
conventional
rigid
devices.
This
paper
reviews
advancements
soft
technologies,
honing
on
various
materials,
manufacturing
techniques,
design
strategies.
We
will
first
highlight
general
approaches
fabrication,
including
appropriate
selection
substrate,
electrodes,
insulation
layers.
then
focus
materials
diodes,
their
integration
strategies,
representative
application
examples.
Next,
we
move
photodetectors,
highlighting
state-of-the-art
fabrication
methods,
followed
At
end,
a
brief
summary
given,
potential
challenges
further
development
of
functional
discussed
conclusion.
