Advances in the research of comorbid insomnia and depression: mechanisms, impacts, and interventions DOI Creative Commons
Tao Gao,

Han Xiang,

Qian Wu

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Insomnia and depression, both significantly impacting public health, are common psychosomatic illnesses that frequently co-occur in the same individual. Not only do these two conditions commonly co-occur, but they also exhibit a bidirectional link, where existence of one may heighten risk for other. Latest research offers compelling evidence significant overlap biological, psychological, sociological aspects comorbidity insomnia depression. Building on this, we aim to examine pathophysiology along with their comorbid mechanisms, encompassing biological routes (like genetics, HPA axis, immune-inflammatory activation, neuroendocrine regulation, microbiome alterations, neural circuits integrating sleep emotion regulation), as well psychosocial routes. Consequently, proposing self-perpetuating mutually reinforcing “snowball effect” model examining corresponding preventative intervention strategies rectify associated imbalances. Finally, this article encapsulates challenges field study directions future research. paper points out limitations current (cross-sectional data being dominant, mechanism multi-omics dynamics unknown) direction (longitudinal cohort combined computational modeling resolve temporal interactions), which will provide theoretical basis precision interventions.

Language: Английский

Dopamine and glutamate regulate striatal acetylcholine in decision-making DOI Creative Commons
Lynne Chantranupong, Celia Beron, Joshua A. Zimmer

et al.

Nature, Journal Year: 2023, Volume and Issue: 621(7979), P. 577 - 585

Published: Aug. 9, 2023

Abstract Striatal dopamine and acetylcholine are essential for the selection reinforcement of motor actions decision-making 1 . In vitro studies have revealed an intrastriatal circuit in which acetylcholine, released by cholinergic interneurons (CINs), drives release dopamine, turn, inhibits activity CINs through D2 receptors (D2Rs). Whether how this contributes to striatal function vivo is largely unknown. Here, define role a living system, we monitored signals ventrolateral striatum mice performing reward-based task. We establish that exhibit multiphasic anticorrelated transients modulated decision history reward outcome. Dopamine dynamics encoding do not require CINs. However, D2R-dependent manner, loss regulation impairs decision-making. To determine other inputs shape signals, assessed contribution cortical thalamic projections, found glutamate from both sources required release. Altogether, uncover dynamic relationship between during decision-making, reveal multiple modes CIN regulation. These findings deepen our understanding neurochemical basis behaviour.

Language: Английский

Citations

88
Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation DOI Creative Commons
Ali Mohebi,

Val Collins,

Joshua D. Berke

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: June 5, 2023

Motivation to work for potential rewards is critically dependent on dopamine (DA) in the nucleus accumbens (NAc). DA release from NAc axons can be controlled by at least two distinct mechanisms: (1) action potentials propagating cell bodies ventral tegmental area (VTA), and (2) activation of β2* nicotinic receptors local cholinergic interneurons (CINs). How CIN activity contributes dynamics behaving animals not well understood. We monitored Core awake, unrestrained rats using sensor RdLight1, while simultaneously monitoring or manipulating same location. stimulation rapidly evoked release, contrast slice preparations, this showed no indication short-term depression receptor desensitization. The sound unexpected food delivery a brief joint increase population with second as approached food. In an operant task, we observed fast ramps during approach behaviors, either start trial collect rewards. These co-occurred ramps, without corresponding changes firing lateral VTA neurons. Finally, examined effects blocking influence over through infusion DHβE, selective antagonist receptors. DHβE dose-dependently interfered motivated decisions, mimicking antagonist. Our results support key CINs behavior via regulation release.

Language: Английский

Citations

52
Activity of a direct VTA to ventral pallidum GABA pathway encodes unconditioned reward value and sustains motivation for reward DOI Creative Commons
Wen‐Liang Zhou, Kristen K.O. Kim, Farhan Ali

et al.

Science Advances, Journal Year: 2022, Volume and Issue: 8(42)

Published: Oct. 19, 2022

Dopamine signaling from the ventral tegmental area (VTA) plays critical roles in reward-related behaviors, but less is known about functions of neighboring VTA GABAergic neurons. We show here that a primary target GABA projection neurons pallidum (VP). Activity VTA-to-VP–projecting correlates consistently with size and palatability reward does not change following cue learning, providing direct measure value. Chemogenetic stimulation this increased activity subset VP were active while mice seeking reward. Optogenetic pathway improved performance cue-reward task maintained motivation to work for over days. This provides information value directly VP, likely distinct prediction error signal carried by dopamine

Language: Английский

Citations

40
Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning DOI

Liv Engel,

Amy R. Wolff,

Madelyn Blake

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(14), P. 3086 - 3101.e4

Published: June 25, 2024

Language: Английский

Citations

10
The nucleus accumbens in reward and aversion processing: insights and implications DOI Creative Commons
Ying Xu, Yingjie Lin, Ming Yu

et al.

Frontiers in Behavioral Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 9, 2024

The nucleus accumbens (NAc), a central component of the brain's reward circuitry, has been implicated in wide range behaviors and emotional states. Emerging evidence, primarily drawing from recent rodent studies, suggests that function NAc aversion processing is multifaceted. Prolonged stress or drug use induces maladaptive neuronal which results pathological conditions. This review aims to provide comprehensive up-to-date insights on role motivated behavior regulation highlights areas demand further in-depth analysis. It synthesizes latest findings how distinct populations pathways contribute opposite valences. examines neuromodulators, especially monoamines, influence NAc's control over various motivational Furthermore, it delves into complex underlying mechanisms psychiatric disorders such as addiction depression evaluates prospective interventions restore functionality.

Language: Английский

Citations

9
AAV11 enables efficient retrograde targeting of projection neurons and enhances astrocyte-directed transduction DOI Creative Commons
Zengpeng Han, Nengsong Luo, Wenyu Ma

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: June 26, 2023

Abstract Viral tracers that enable efficient retrograde labeling of projection neurons are powerful vehicles for structural and functional dissections the neural circuit treatment brain diseases. Currently, some recombinant adeno-associated viruses (rAAVs) based on capsid engineering widely used tracing, but display undesirable area selectivity due to inefficient transduction in certain connections. Here we developed an easily editable toolkit produce high titer AAV11 demonstrated it exhibits potent stringent adult male wild-type or Cre transgenic mice. can function as a viral tracer complementary AAV2-retro multiple In combination with fiber photometry, be monitor neuronal activities network by delivering calcium-sensitive indicator under control neuron-specific promoter Cre- lox system. Furthermore, showed GfaABC 1 D embedding is superior AAV8 AAV5 astrocytic tropism vivo, combined bidirectional multi-vector axoastrocytic labeling, study neuron-astrocyte connection. Finally, allows analyzing connectivity difference brains Alzheimer’s disease These properties make promising tool mapping manipulating circuits gene therapy neurological neurodegenerative disorders.

Language: Английский

Citations

19
The nucleus accumbens shell: a neural hub at the interface of homeostatic and hedonic feeding DOI Creative Commons

A Marinescu,

Marie A. Labouesse

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 30, 2024

Feeding behavior is a complex physiological process regulated by the interplay between homeostatic and hedonic feeding circuits. Among neural structures involved, nucleus accumbens (NAc) has emerged as pivotal region at interface of these two The NAc comprises distinct subregions in this review, we focus mainly on shell (NAcSh). Homeostatic circuits, primarily found hypothalamus, ensure organism's balance energy nutrient requirements. These circuits monitor peripheral signals, such insulin, leptin, ghrelin, modulate satiety hunger states. NAcSh receives input from integrating information regarding metabolic needs. Conversely, so-called involve all other non-hunger -satiety processes, i.e., sensory information, associative learning, reward, motivation pleasure associated with food consumption. interconnected hedonics-related like ventral tegmental area prefrontal cortex plays key role encoding related to palatable seeking or In sum, acts crucial hub behavior, signals both facilitate behavioral output via its downstream projections. Moreover, NAcSh's involvement extends beyond simple integration, it directly impacts actions first delineating inputs targeting NAcSh; then present projections structures. Finally discuss how regulates can be seen functionally diverse set projection neuron subpopulations.

Language: Английский

Citations

8
Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons DOI Creative Commons
Daisuke Sato,

Michiko Narita,

Yusuke Hamada

et al.

Molecular Brain, Journal Year: 2022, Volume and Issue: 15(1)

Published: Jan. 6, 2022

Abstract Emerging evidence suggests that the mesolimbic dopaminergic network plays a role in modulation of pain. As chronic pain conditions are associated with hypodopaminergic tone nucleus accumbens (NAc), we evaluated effects increasing signaling at dopamine D1/D2-expressing neurons NAc model neuropathic induced by partial ligation sciatic nerve. Bilateral microinjection either selective D1-receptor (Gs-coupled) agonist Chloro-APB or D2-receptor (Gi-coupled) quinpirole into partially reversed nerve injury-induced thermal allodynia. Either optical stimulation D1-receptor-expressing suppression D2-receptor-expressing both inner and outer substructures also transiently, but significantly, restored Under pain-like condition, specific facilitation terminals projecting to VTA revealed feedforward-like antinociceptive circuit. Additionally, functional cholinergic interneurons negatively positively control activity D1- neurons, respectively, transiently elicited anti-allodynic injured animals. These findings suggest comprehensive activation integrated may lead significant relief

Language: Английский

Citations

24
Updating the striatal–pallidal wiring diagram DOI
Lisa Z. Fang, Meaghan C. Creed

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 27(1), P. 15 - 27

Published: Dec. 6, 2023

Language: Английский

Citations

16
Deep tissue super-resolution imaging with adaptive optical two-photon multifocal structured illumination microscopy DOI Creative Commons
Chenshuang Zhang, Bin Yu,

Fangrui Lin

et al.

PhotoniX, Journal Year: 2023, Volume and Issue: 4(1)

Published: Dec. 21, 2023

Abstract Visualization of axons and dendritic spines is crucial in neuroscience research. However, traditional microscopy limited by diffraction-limited resolution shallow imaging depth, making it difficult to study neuronal dynamics. Two-photon multifocal structured illumination (2P-MSIM) provides super-resolution along with a reasonably good penetration, but vulnerable optical aberrations deep tissues. Herein we present novel non-inertial scanning 2P-MSIM system incorporated adaptive optics (AO) which allows for effective aberration correction. Our strategy designed correct both laser fluorescence paths simultaneously using spatial light modulator deformable mirror respectively, providing better results than the individual path corrections. The successful implementation two-photon (AO 2P-MSIM) has allowed structures mouse brain slice at great depths dynamic morphological characteristics zebrafish motoneurons vivo.

Language: Английский

Citations

15