Neuronal coupling modes show differential development in the early cortical activity networks of human newborns DOI
Pauliina Yrjölä, Sampsa Vanhatalo, Anton Tokariev

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(26), P. e1012232024 - e1012232024

Published: May 20, 2024

The third trimester is a critical period for the development of functional networks that support lifelong neurocognitive performance, yet emergence neuronal coupling in these poorly understood. Here, we used longitudinal high-density electroencephalographic recordings from preterm infants during 33 to 45 weeks conceptional age (CA) characterize early spatiotemporal patterns local cortical function and intrinsic modes [ICMs; phase–phase (PPCs), amplitude–amplitude (AACs), phase–amplitude correlations (PACs)]. Absolute power showed robust increase with CA across full frequency spectrum, while PACs sleep state-specific, biphasic peaked few before normal birth. AACs distant decreased globally at nearly all frequencies. In contrast, PPCs frequency- region-selective development, an strength between frontal, central, occipital regions low-delta alpha frequencies together wider-spread decrease other Our findings present spectrally spatially differential distinct ICMs neonatal provide their developmental templates future basic clinical research.

Language: Английский

Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth DOI
Valerie J. Sydnor,

Bart Larsen,

Jakob Seidlitz

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(4), P. 638 - 649

Published: March 27, 2023

Language: Английский

Citations

107
Insights into Alzheimer’s disease from single-cell genomic approaches DOI
Mitchell H. Murdock, Li‐Huei Tsai

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(2), P. 181 - 195

Published: Jan. 2, 2023

Language: Английский

Citations

101
Neuronal ambient RNA contamination causes misinterpreted and masked cell types in brain single-nuclei datasets DOI Creative Commons
Emre Caglayan, Yuxiang Liu, Geneviève Konopka

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(24), P. 4043 - 4056.e5

Published: Oct. 13, 2022

Language: Английский

Citations

72
Functional myelin in cognition and neurodevelopmental disorders DOI Creative Commons
Hasni Khelfaoui, Cristobal Ibaceta‐Gonzalez, Marı́a Cecilia Angulo

et al.

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: April 13, 2024

Abstract In vertebrates, oligodendrocytes (OLs) are glial cells of the central nervous system (CNS) responsible for formation myelin sheath that surrounds axons neurons. The plays a crucial role in transmission neuronal information by promoting rapid saltatory conduction action potentials and providing neurons with structural metabolic support. Saltatory conduction, first described peripheral (PNS), is now generally recognized as universal evolutionary innovation to respond quickly environment: helps us think act fast. Nevertheless, system, especially brain, may not be primarily focused on accelerating speed but rather ensuring precision. Its principal function could coordinate various networks, their synchronization through oscillations (or rhythms) relevant specific processing tasks. Interestingly, has been directly involved different types cognitive processes relying brain oscillations, plasticity currently considered part fundamental mechanisms memory maintenance. However, despite ample evidence showing involvement cognition neurodevelopmental disorders characterized impairments, link between myelin, disease yet fully understood. this review, we aim highlight what known remains explored understand high order processes.

Language: Английский

Citations

17
Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration DOI Creative Commons
Jun‐yi Zhu, Yijia Zhang,

Yinuo Sun

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 2, 2025

The applications of nanomaterials in regenerative medicine encompass a broad spectrum. functional nanomaterials, such as Prussian blue and its derivative nanoparticles, exhibit potent anti-inflammatory antioxidant properties. By combining it with the corresponding scaffold carrier, fusion biotherapy can be achieved, thereby providing potential avenue for clinical treatment. present study demonstrates fabrication Mesoporous nanoparticles (MPBN) functionalized Inverse Opal Film (IOF) neuroconduit peripheral nerve repair through reverse replication freeze-drying techniques. binding MPBN to effectively decreasing reactive oxygen species inflammatory factors vicinity residual nerve, protective effects on damaged nerve. Furthermore, comprehensive behavioral, electrophysiological, pathological analyses unequivocally substantiate efficacy increasing structure regeneration ameliorating denervation-induced myopathy. Moreover, enhances capacity Schwann cells by activating AMPK/SIRT1/PGC-1 pathway. findings suggest that MPBN, biocompatible nanoparticle, safeguard nerves optimizing microenvironment surrounding augmenting cells, facilitating repair. This also establishes theoretical foundation exploring integration translation between biotherapy.

Language: Английский

Citations

4
Myelin lipid metabolism and its role in myelination and myelin maintenance DOI Creative Commons
Joseph A. Barnes-Vélez, Fatma Betul Aksoy Yasar, Jian Hu

et al.

The Innovation, Journal Year: 2022, Volume and Issue: 4(1), P. 100360 - 100360

Published: Dec. 7, 2022

Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high abundance of lipids one myelin's salient features that contribute to its unique role as an insulator electrically isolates fibers across their myelinated surface. most abundant in myelin include cholesterol, glycosphingolipids, and plasmalogens, each playing critical roles development well function. This review serves summarize the lipid metabolism myelination maintenance, molecular determinants homeostasis, with emphasis on findings from genetic models. In addition, implications dysmetabolism human diseases are highlighted context hereditary leukodystrophies neuropathies acquired disorders such Alzheimer's disease.

Language: Английский

Citations

46
Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex DOI Creative Commons

Aleksandra Mężydło,

Nils Treiber,

Emily M. Ullrich Gavilanes

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(11), P. 1748 - 1759.e8

Published: April 17, 2023

Language: Английский

Citations

42
Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals DOI Creative Commons
Zhaoyuan Gong, Murat Bilgel, Matthew Kiely

et al.

Alzheimer s & Dementia, Journal Year: 2023, Volume and Issue: 19(7), P. 3098 - 3107

Published: Jan. 31, 2023

The influence of myelination on longitudinal changes in cognitive performance remains unclear.

Language: Английский

Citations

40
Myelin in Alzheimer’s disease: culprit or bystander? DOI Creative Commons
Michel Maître, Hélène Jeltsch‐David, Nwife Getrude Okechukwu

et al.

Acta Neuropathologica Communications, Journal Year: 2023, Volume and Issue: 11(1)

Published: March 31, 2023

Alzheimer's disease (AD) is a neurodegenerative disorder with neuronal and synaptic losses due to the accumulation of toxic amyloid β (Αβ) peptide oligomers, plaques, tangles containing tau (tubulin-associated unit) protein. While familial AD caused by specific mutations, sporadic more common appears result from complex chronic brain neuroinflammation mitochondriopathies, inducing free radicals' accumulation. In aged brain, mutations in DNA several unfolded proteins participate amyloidosis response effect on myelin sheath axons, leading cognitive deficits dementia. Αβ peptides are most frequent form oligomers. Accumulations misfolded during years alters different metabolic mechanisms, induce inflammatory immune responses consequences cells. Myelin composition architecture may appear be an early target for activity Aβ others hydrophobic proteins. this work, we describe possible role alterations genesis onset symptomatology. We propose that some pathophysiological clinical forms arise structural disorders processes myelination/demyelination regions where non-functional important. these forms, primacy deleterious would matter questioning initiating neuropathology primarily fact dysmyelination.

Language: Английский

Citations

38
The Gut–Brain Axis in Schizophrenia: The Implications of the Gut Microbiome and SCFA Production DOI Open Access

Songhyun Ju,

Yoonhwa Shin,

Sunhee Han

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4391 - 4391

Published: Oct. 16, 2023

Schizophrenia, a severe mental illness affecting about 1% of the population, manifests during young adulthood, leading to abnormal function and behavior. Its multifactorial etiology involves genetic factors, experiences adversity, infection, gene-environment interactions. Emerging research indicates that maternal infection or stress pregnancy may also increase schizophrenia risk in offspring. Recent on gut-brain axis highlights gut microbiome's potential influence central nervous system (CNS) health, including schizophrenia. The microbiota, located digestive system, has significant role play human physiology, immune development, vitamin synthesis, protection against pathogenic bacteria. Disruptions caused by diet, medication use, environmental pollutants, stress, lead imbalances with far-reaching effects CNS health. Of interest are short-chain fatty acids (SCFAs), metabolic byproducts produced microbes fermentation. SCFAs can cross blood-brain barrier, influencing activity, microglia cytokine modulation. dysregulation neurotransmitters contribute disorders, This review explores relationship between SCFAs, microbiome, Our aim is deepen understanding elucidate its implications for future therapeutic approaches.

Language: Английский

Citations

33