Cerebral Cortex,
Journal Year:
2022,
Volume and Issue:
33(9), P. 5075 - 5081
Published: Oct. 5, 2022
Abstract
It
is
well
documented
that
some
brain
regions,
such
as
association
cortices,
caudate,
and
hippocampus,
are
particularly
prone
to
age-related
atrophy,
but
it
has
been
hypothesized
there
individual
differences
in
atrophy
profiles.
Here,
we
document
heterogeneity
regional-atrophy
patterns
using
latent-profile
analysis
of
1,482
longitudinal
magnetic
resonance
imaging
observations.
The
results
supported
a
2-group
solution
reflecting
rates
cortical
regions
hippocampus
along
with
comparable
caudate
atrophy.
higher-atrophy
group
had
the
most
marked
also
lower
episodic
memory,
their
normal
rate
was
accompanied
by
larger
baseline
volumes.
Our
findings
support
refine
models
aging
suggest
distinct
mechanisms
striatal
versus
hippocampal-cortical
systems.
BMC Psychiatry,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: May 6, 2024
Abstract
Background
Obstructive
sleep
apnea
(OSA)
is
a
pervasive,
chronic
sleep-related
respiratory
condition
that
causes
brain
structural
alterations
and
cognitive
impairments.
However,
the
causal
association
of
OSA
with
morphology
performance
has
not
been
determined.
Methods
We
conducted
two-sample
bidirectional
Mendelian
randomization
(MR)
analysis
to
investigate
relationship
between
range
neurocognitive
characteristics,
including
cortical
structure,
subcortical
change
across
lifespan,
performance.
Summary-level
GWAS
data
for
from
FinnGen
consortium
was
used
identify
genetically
predicted
OSA.
Data
regarding
characteristics
were
obtained
published
meta-analysis
studies.
Linkage
disequilibrium
score
regression
employed
reveal
genetic
correlations
related
traits.
Results
Our
MR
study
provided
evidence
found
significantly
increase
volume
hippocampus
(IVW
β
(95%
CI)
=
158.997
(76.768
241.227),
P
1.51e-04),
no
heterogeneity
pleiotropy
detected.
Nominally
effects
on
structures,
such
as
thickness
temporal
pole
or
without
global
weighted,
amygdala
structure
change,
cerebellum
white
matter
covering
observed.
Bidirectional
links
also
detected
subcortical,
performance,
risk.
LDSC
showed
significant
correlation
volume.
Conclusions
Overall,
we
observed
positive
These
findings
may
provide
new
insights
into
features,
PLoS Biology,
Journal Year:
2024,
Volume and Issue:
22(6), P. e3002647 - e3002647
Published: June 20, 2024
The
human
brain
is
organized
as
segregation
and
integration
units
follows
complex
developmental
trajectories
throughout
life.
cortical
manifold
provides
a
new
means
of
studying
the
brain’s
organization
in
multidimensional
connectivity
gradient
space.
However,
how
morphometric
changes
across
lifespan
remains
unclear.
Here,
leveraging
structural
magnetic
resonance
imaging
scans
from
1,790
healthy
individuals
aged
8
to
89
years,
we
investigated
age-related
global,
within-
between-network
dispersions
reveal
networks
3D
manifolds
based
on
similarity
network
(MSN),
combining
multiple
features
conceptualized
“fingerprint”
an
individual’s
brain.
Developmental
global
dispersion
unfolded
along
patterns
molecular
organization,
such
acetylcholine
receptor.
Communities
were
increasingly
dispersed
with
age,
reflecting
more
disassortative
profiles
within
community.
Increasing
within-network
primary
motor
association
cortices
mediated
influence
age
cognitive
flexibility
executive
functions.
We
also
found
that
secondary
sensory
decreasingly
rest
during
aging,
possibly
indicating
shift
extreme
central
position
manifolds.
Together,
our
results
MSN
perspective
space,
providing
insights
into
brain,
well
performance.
Nature Aging,
Journal Year:
2024,
Volume and Issue:
4(9), P. 1263 - 1278
Published: Aug. 14, 2024
Abstract
Infections
have
been
associated
with
the
incidence
of
Alzheimer
disease
and
related
dementias,
but
mechanisms
responsible
for
these
associations
remain
unclear.
Using
a
multicohort
approach,
we
found
that
influenza,
viral,
respiratory,
skin
subcutaneous
infections
were
increased
long-term
dementia
risk.
These
also
region-specific
brain
volume
loss,
most
commonly
in
temporal
lobe.
We
identified
260
out
942
immunologically
relevant
proteins
plasma
differentially
expressed
individuals
an
infection
history.
Of
infection-related
proteins,
35
predicted
volumetric
changes
regions
vulnerable
to
infection-specific
atrophy.
Several
including
PIK3CG,
PACSIN2,
PRKCB,
cognitive
decline
biomarkers
(Aβ
42/40
,
GFAP,
NfL,
pTau-181).
Genetic
variants
influenced
expression
ITGB6
TLR5,
loss.
Our
findings
support
role
risk
identify
molecular
mediators
by
which
may
contribute
neurodegeneration.
Cerebral Cortex,
Journal Year:
2022,
Volume and Issue:
33(9), P. 5075 - 5081
Published: Oct. 5, 2022
Abstract
It
is
well
documented
that
some
brain
regions,
such
as
association
cortices,
caudate,
and
hippocampus,
are
particularly
prone
to
age-related
atrophy,
but
it
has
been
hypothesized
there
individual
differences
in
atrophy
profiles.
Here,
we
document
heterogeneity
regional-atrophy
patterns
using
latent-profile
analysis
of
1,482
longitudinal
magnetic
resonance
imaging
observations.
The
results
supported
a
2-group
solution
reflecting
rates
cortical
regions
hippocampus
along
with
comparable
caudate
atrophy.
higher-atrophy
group
had
the
most
marked
also
lower
episodic
memory,
their
normal
rate
was
accompanied
by
larger
baseline
volumes.
Our
findings
support
refine
models
aging
suggest
distinct
mechanisms
striatal
versus
hippocampal-cortical
systems.
