Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 23, 2025
Abstract
Spinal
cord
injury
(SCI)
constitutes
a
critical
occurrence
that
results
in
the
disruption
of
both
motor
and
sensory
functions.
Oxidative
stress‐induced
apoptosis
pyroptosis
have
been
identified
as
contributors
to
neuronal
damage
during
secondary
phase
following
SCI.
Therefore,
this
study
focuses
on
development
self‐enhancing
drug
pair‐driven
selenium
(Se)
nanotherapeutics,
loading
with
2,3,5,6‐tetramethylpyrazine
(TMP)
Ginsenoside
Rg1
(Rg1),
enhance
treatment
The
engineered
LET/TMP/Rg1@Se
NPs
exhibits
remarkable
antioxidant
properties,
effectively
reducing
oxidative
by
minimizing
reactive
oxygen
species
(ROS)
accumulation
restoring
mitochondrial
function.
In
addition
their
effects,
nanotherapeutics
demonstrates
significant
anti‐pyroptotic
effects
BV2
microglial
cells
modulating
NLRP3/caspase‐1
pathway,
leading
decreased
release
pro‐inflammatory
cytokines
IL‐1β
IL‐18.
Moreover,
inhibition
inflammatory
cascade
response
diminishes
neuroinflammation‐induced
promotes
axonal
regeneration
neurons
vitro.
mouse
model
SCI,
improved
function
regeneration,
attributed
pyroptosis,
highlighting
scientific
basis
for
synergistic
effect
Se
an
innovative
strategy
effective
SCI
therapy.
Advanced technology in neuroscience .,
Journal Year:
2025,
Volume and Issue:
2(1), P. 16 - 26
Published: Feb. 6, 2025
Spinal
cord
injury
is
a
severe
traumatic
disorder
of
the
central
nervous
system.
Cell
therapy
one
primary
treatment
options
for
spinal
injury,
and
it
has
been
shown
to
have
substantial
effect
on
treatment.
However,
mechanisms
underlying
cell
transplantation
remain
poorly
understood.
The
transition
from
fundamental
research
clinical
application
impeded
by
unresolved
mechanistic
uncertainties,
ethical
safety
concerns,
outdated
methodologies.
Herein,
we
summarize
which
aids
in
recovery
highlight
recent
advances
relevant
methodologies
technologies,
address
challenges
faced
translation.
A
better
understanding
these
overcoming
hurdles
translating
into
practice
are
crucial
hold
considerable
promise
advancing
field.
Science Robotics,
Journal Year:
2025,
Volume and Issue:
10(100)
Published: March 12, 2025
Rehabilitation
robotics
aims
to
promote
activity-dependent
reorganization
of
the
nervous
system.
However,
people
with
paralysis
cannot
generate
sufficient
activity
during
robot-assisted
rehabilitation
and,
consequently,
do
not
benefit
from
these
therapies.
Here,
we
developed
an
implantable
spinal
cord
neuroprosthesis
operating
in
a
closed
loop
robust
walking
and
cycling
assisted
by
robotic
devices.
This
is
device
agnostic
designed
for
seamless
implementation
nonexpert
users.
Preliminary
evaluations
participants
showed
that
enabled
well-organized
patterns
muscle
cycling.
A
proof-of-concept
study
suggested
augmented
promoted
sustained
neurological
improvements.
Moreover,
recreational
activities
outdoors.
Future
clinical
trials
will
have
confirm
findings
broader
population.
Frontiers in Neural Circuits,
Journal Year:
2025,
Volume and Issue:
19
Published: March 21, 2025
Descending
neural
pathways
to
the
spinal
cord
plays
vital
roles
in
motor
control.
They
are
often
damaged
by
brain
injuries
such
as
stroke
and
trauma,
which
lead
severe
impairments.
Due
limited
capacity
for
regeneration
of
circuits
adult
central
nervous
system,
currently
no
essential
treatments
available
complete
recovery.
Notably,
accumulating
evidence
shows
that
residual
descending
dynamically
reorganized
after
injury
contribute
Furthermore,
recent
technological
advances
cell-type
classification
manipulation
have
highlighted
structural
functional
diversity
these
pathways.
Here,
we
focus
on
three
major
pathways,
namely,
corticospinal
tract
from
cerebral
cortex,
rubrospinal
red
nucleus,
reticulospinal
reticular
formation,
summarize
current
knowledge
their
structures
functions,
especially
rodent
models
(mice
rats).
We
then
review
discuss
process
patterns
reorganization
induced
following
injury,
compensate
lost
connections
Understanding
basic
properties
each
pathway
principles
induction
outcome
rewired
will
provide
therapeutic
insights
enhance
interactive
rewiring
multiple
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 23, 2025
Abstract
Spinal
cord
injury
(SCI)
constitutes
a
critical
occurrence
that
results
in
the
disruption
of
both
motor
and
sensory
functions.
Oxidative
stress‐induced
apoptosis
pyroptosis
have
been
identified
as
contributors
to
neuronal
damage
during
secondary
phase
following
SCI.
Therefore,
this
study
focuses
on
development
self‐enhancing
drug
pair‐driven
selenium
(Se)
nanotherapeutics,
loading
with
2,3,5,6‐tetramethylpyrazine
(TMP)
Ginsenoside
Rg1
(Rg1),
enhance
treatment
The
engineered
LET/TMP/Rg1@Se
NPs
exhibits
remarkable
antioxidant
properties,
effectively
reducing
oxidative
by
minimizing
reactive
oxygen
species
(ROS)
accumulation
restoring
mitochondrial
function.
In
addition
their
effects,
nanotherapeutics
demonstrates
significant
anti‐pyroptotic
effects
BV2
microglial
cells
modulating
NLRP3/caspase‐1
pathway,
leading
decreased
release
pro‐inflammatory
cytokines
IL‐1β
IL‐18.
Moreover,
inhibition
inflammatory
cascade
response
diminishes
neuroinflammation‐induced
promotes
axonal
regeneration
neurons
vitro.
mouse
model
SCI,
improved
function
regeneration,
attributed
pyroptosis,
highlighting
scientific
basis
for
synergistic
effect
Se
an
innovative
strategy
effective
SCI
therapy.
