Survey of hippocampal responses to sound in naïve mice reveals widespread activation by broadband noise onsets DOI Creative Commons
James H. Bigelow,

Toshiaki SUZUKI,

Yulang Wu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 20, 2025

Abstract Recent studies suggest some hippocampal (HC) neurons respond to passively presented sounds in naïve subjects, but the specificity and prevalence of these responses remain unclear. We used Neuropixels probes record unit activity HC auditory cortex (ACtx) awake, untrained mice during presentation diverse sound stimuli. A subset exhibited reliable, short-latency passive sounds, including tones broadband noise. units showed evidence tuning for tone frequency not spectrotemporal features continuous dynamic moving ripples. Across types, overwhelmingly occurred at stimulus onset; they quickly adapted did offset. Among all tested, noise was by far most effective driving activity, with response scaling increasing spectral bandwidth density. Responses were also more common than visual flash Sound-evoked face movements, quantified total facial motion energy (FME), correlated population-level many individual responded regardless movement, indicating both motor-related inputs. These results show that abrupt, acoustic events are sufficient activate absence learning or behavioral engagement. This suggests a possible role detecting salient environmental changes supports idea inputs contribute directly function. Given emerging links between hearing loss dementia, findings highlight potential pathway which deafferentation could impact cognitive health.

Language: Английский

Analysis methods for large-scale neuronal recordings DOI
Carsen Stringer, Marius Pachitariu

Science, Journal Year: 2024, Volume and Issue: 386(6722)

Published: Nov. 7, 2024

Simultaneous recordings from hundreds or thousands of neurons are becoming routine because innovations in instrumentation, molecular tools, and data processing software. Such can be analyzed with science methods, but it is not immediately clear what methods to use how adapt them for neuroscience applications. We review, categorize, illustrate diverse analysis neural population describe these have been used make progress on longstanding questions neuroscience. review a variety approaches, ranging the mathematically simple complex, exploratory hypothesis-driven, recently developed more established methods. also some common statistical pitfalls analyzing large-scale data.

Language: Английский

Citations

4
Visual experience orthogonalizes visual cortical stimulus responses via population code transformation DOI Creative Commons
Samuel Failor, Matteo Carandini, Kenneth D. Harris

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115235 - 115235

Published: Jan. 30, 2025

Language: Английский

Citations

0
Orexin population activity precisely reflects net body movement across behavioral and metabolic states DOI Open Access

Alexander L Tesmer,

Paulius Viskaitis,

Dane Donegan

et al.

Published: Feb. 7, 2025

Tracking net body movement in real time may enable the brain to estimate ongoing demands and thus better orchestrate muscle tone, energy balance, arousal. To identify neural populations specializing tracking movement, here we compared self-initiated movement-related activity across genetically-defined subcortical neurons mouse brain, including dopaminergic, glutamatergic, noradrenergic, key peptidergic neurons. We show that hypothalamic orexin/hypocretin-producing (HONs) are exceptionally precise movement-trackers, encoding multiple classified behaviors with a high degree of precision, independent head acceleration. This was so precise, video analysis reliably served as low-cost biometric for HON population activity. The internal nutritional states, occurred communication bandwidth distinct from blood glucose. At projection targets, orexin/hypocretin peptide outputs correlated projection-specific manner, indicating functional heterogeneity outputs. Finally, found not encoded same extent other related arousal or energy. These findings indicate orchestrators metabolism finely tuned encode constituting bridge multiplexing motor resources.

Language: Английский

Citations

0
Orexin population activity precisely reflects net body movement across behavioral and metabolic states DOI Open Access

Alexander L Tesmer,

Paulius Viskaitis,

Dane Donegan

et al.

Published: Feb. 7, 2025

Tracking net body movement in real time may enable the brain to estimate ongoing demands and thus better orchestrate muscle tone, energy balance, arousal. To identify neural populations specializing tracking movement, here we compared self-initiated movement-related activity across genetically-defined subcortical neurons mouse brain, including dopaminergic, glutamatergic, noradrenergic, key peptidergic neurons. We show that hypothalamic orexin/hypocretin-producing (HONs) are exceptionally precise movement-trackers, encoding multiple classified behaviors with a high degree of precision, independent head acceleration. This was so precise, video analysis reliably served as low-cost biometric for HON population activity. The internal nutritional states, occurred communication bandwidth distinct from blood glucose. At projection targets, orexin/hypocretin peptide outputs correlated projection-specific manner, indicating functional heterogeneity outputs. Finally, found not encoded same extent other related arousal or energy. These findings indicate orchestrators metabolism finely tuned encode constituting bridge multiplexing motor resources.

Language: Английский

Citations

0
Survey of hippocampal responses to sound in naïve mice reveals widespread activation by broadband noise onsets DOI Creative Commons
James H. Bigelow,

Toshiaki SUZUKI,

Yulang Wu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 20, 2025

Abstract Recent studies suggest some hippocampal (HC) neurons respond to passively presented sounds in naïve subjects, but the specificity and prevalence of these responses remain unclear. We used Neuropixels probes record unit activity HC auditory cortex (ACtx) awake, untrained mice during presentation diverse sound stimuli. A subset exhibited reliable, short-latency passive sounds, including tones broadband noise. units showed evidence tuning for tone frequency not spectrotemporal features continuous dynamic moving ripples. Across types, overwhelmingly occurred at stimulus onset; they quickly adapted did offset. Among all tested, noise was by far most effective driving activity, with response scaling increasing spectral bandwidth density. Responses were also more common than visual flash Sound-evoked face movements, quantified total facial motion energy (FME), correlated population-level many individual responded regardless movement, indicating both motor-related inputs. These results show that abrupt, acoustic events are sufficient activate absence learning or behavioral engagement. This suggests a possible role detecting salient environmental changes supports idea inputs contribute directly function. Given emerging links between hearing loss dementia, findings highlight potential pathway which deafferentation could impact cognitive health.

Language: Английский

Citations

0