Nature, Journal Year: 2023, Volume and Issue: 623(7986), P. 247 - 250
Published: Nov. 7, 2023
Language: Английский
Nature, Journal Year: 2024, Volume and Issue: 626(8000), P. 808 - 818
Published: Feb. 7, 2024
Neuronal signals that are relevant for spatial navigation have been described in many species
Language: Английский
Citations
44
Current Opinion in Insect Science, Journal Year: 2022, Volume and Issue: 54, P. 100968 - 100968
Published: Sept. 13, 2022
Methods to acquire and process synaptic-resolution electron-microscopy datasets have progressed very rapidly, allowing production annotation of larger, more complete connectomes. More accurate neuronal matching techniques are enriching cell type data with gene expression, neuron activity, behaviour developmental information, providing ways test hypotheses circuit function. In a variety behaviours such as learned innate olfaction, navigation sexual behaviour, connectomics has already revealed interconnected modules hierarchical structure, recurrence integration sensory streams. Comparing individual connectomes determine which features robust variable is one key research area; new work in comparative across development, experience, sex species will establish strong links between connectivity brain
Language: Английский
Citations
43
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Sept. 20, 2023
Neural processing of a desired moving direction requires the continuous comparison between current heading and goal direction. While neural basis underlying is well-studied, coding remains unclear in insects. Here, we used tetrode recordings tethered flying monarch butterflies to unravel how represented insect brain. recording, maintained robust directions relative virtual sun. By resetting their directions, found neurons whose spatial tuning was tightly linked directions. Importantly, unaffected when changed after compass perturbations, showing that these specifically encode Overall, here discovered invertebrate goal-direction share functional similarities cells reported mammals. Our results give insights into evolutionarily conserved principles goal-directed orientation animals.
Language: Английский
Citations
22
Nature, Journal Year: 2024, Volume and Issue: 634(8033), P. 397 - 406
Published: Aug. 28, 2024
Spatial learning in teleost fish requires an intact telencephalon
Language: Английский
Citations
10
Entropy, Journal Year: 2025, Volume and Issue: 27(1), P. 90 - 90
Published: Jan. 19, 2025
In the Kolmogorov Theory of Consciousness, algorithmic agents utilize inferred compressive models to track coarse-grained data produced by simplified world models, capturing regularities that structure subjective experience and guide action planning. Here, we study dynamical aspects this framework examining how requirement tracking natural drives structural properties agent. We first formalize notion a generative model using language symmetry from group theory, specifically employing Lie pseudogroups describe continuous transformations characterize invariance in data. Then, adopting generic neural network as proxy for agent system drawing parallels Noether’s theorem physics, demonstrate forces mirror model. This dual constraint on agent’s constitutive parameters repertoire enforces hierarchical organization consistent with manifold hypothesis network. Our findings bridge perspectives information theory (Kolmogorov complexity, modeling), (group theory), dynamics (conservation laws, reduced manifolds), offering insights into correlates agenthood structured systems, well design artificial intelligence computational brain.
Language: Английский
Citations
1
Cell, Journal Year: 2022, Volume and Issue: 185(26), P. 5011 - 5027.e20
Published: Dec. 1, 2022
To track and control self-location, animals integrate their movements through space. Representations of self-location are observed in the mammalian hippocampal formation, but it is unknown if positional representations exist more ancient brain regions, how they arise from integrated self-motion, by what pathways locomotion. Here, a head-fixed, fictive-swimming, virtual-reality preparation, we exposed larval zebrafish to variety involuntary displacements. They tracked these displacements and, many seconds later, moved toward earlier location corrective swimming ("positional homeostasis"). Whole-brain functional imaging revealed network medulla that stores memory induces an error signal inferior olive drive future swimming. Optogenetically manipulating medullary integrator cells evoked displacement-memory behavior. Ablating them, or downstream olivary neurons, abolished displacement corrections. These results reveal multiregional hindbrain circuit vertebrates integrates self-motion locomotor
Language: Английский
Citations
36
Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(11), P. 904 - 917
Published: Oct. 10, 2024
Language: Английский
Citations
7
Current Biology, Journal Year: 2024, Volume and Issue: 34(3), P. 489 - 504.e7
Published: Jan. 10, 2024
Animals must maintain physiological processes within an optimal temperature range despite changes in their environment. Through behavioral assays, whole-brain functional imaging, and neural ablations, we show that larval zebrafish, ectothermic vertebrate, achieves thermoregulation through homeostatic navigation-non-directional directional movements toward the closest to its setpoint. A brain-wide circuit encompassing several brain regions enables this behavior. We identified preoptic area of hypothalamus (PoA) as a key structure triggering non-directional reorientation when thermal conditions are worsening. This result shows evolutionary conserved role PoA principal thermoregulator also ectotherms. further habenula (Hb)-interpeduncular nucleus (IPN) retains short-term memory sensory history support generation coherent directed even absence continuous cues. finally provide evidence may not be exclusive for but convey more abstract representation relative valence physiologically meaningful stimuli regardless specific identity enable navigation.
Language: Английский
Citations
5
Current Biology, Journal Year: 2023, Volume and Issue: 33(24), P. 5467 - 5477.e4
Published: Dec. 1, 2023
Danionella cerebrum (DC) is a promising vertebrate animal model for systems neuroscience due to its small adult brain volume and inherent optical transparency, but the scope of their cognitive abilities remains an area active research. In this work, we established behavioral paradigm study visual spatial navigation in DC investigate navigational capabilities strategies. We initially observed that exhibit strong negative phototaxis groups less so as individuals. Using dark preference motivator, designed task inspired by Morris water maze. Through series environmental cue manipulations, found utilize cues anticipate reward location evidence landmark-based strategies wherein could use both proximal distal cues. When subsets were occluded, capable using distant contextual information solve task, providing allocentric navigation. Without cues, tended seek out direct line sight with at least one while maintaining positional bias toward location. total, our results suggest can be used neural mechanisms underlying cellular resolution imaging across brain.
Language: Английский
Citations
12
Science, Journal Year: 2024, Volume and Issue: 386(6722)
Published: Nov. 7, 2024
Simultaneous recordings from hundreds or thousands of neurons are becoming routine because innovations in instrumentation, molecular tools, and data processing software. Such can be analyzed with science methods, but it is not immediately clear what methods to use how adapt them for neuroscience applications. We review, categorize, illustrate diverse analysis neural population describe these have been used make progress on longstanding questions neuroscience. review a variety approaches, ranging the mathematically simple complex, exploratory hypothesis-driven, recently developed more established methods. also some common statistical pitfalls analyzing large-scale data.
Language: Английский
Citations
4