The neuroimmune connectome in health and disease

Nature, Journal Year: 2025, Volume and Issue: 638(8050), P. 333 - 342

Published: Feb. 12, 2025

Language: Английский

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From air to mind: unraveling the impact of indoor pollutants on psychiatric disorders

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Epidemiological evidence from the past 20 years indicates that environmental chemicals brought into air by vaporization of volatile organic compounds and other anthropogenic pollutants might be involved, at least in part, development or progression psychiatric disorders. This comes primarily occupational work studies humans, with indoor occupations being most important sources airborne affecting neural circuits implicated mood disorders (e.g., major depressive disorder bipolar disorder). The current mini review brings together recent findings pollution different fields research, including genetics, neuropathology, neuroimaging, for gauging underlying physiological mechanisms leading to emotional disturbances impact nearly all aspects human behavior. A better understanding how affect brain neurons augment clinical symptoms associated will undoubtedly useful subsequent treatment patients and/or article is part themed issue, "Understanding Link Between Environmental Pollutants, Brain & Behavior."

Language: Английский

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Quaternary Ammonium Compounds in Paired Human Urine and Feces: Relative Significance of Biliary Elimination

Environmental Science & Technology Letters, Journal Year: 2024, Volume and Issue: 11(6), P. 533 - 538

Published: May 29, 2024

Quaternary ammonium compounds (QACs) are widely used as disinfectants in consumer and medicinal products that contribute to widespread human exposure. We determined 7 benzylalkyldimethylammonium (BACs), 6 dialkyldimethylammonium (DDACs), alkyltrimethylammonium (ATMACs), 8 metabolites of BACs (BACm) paired urine feces. found QACs feces at total concentrations (∑All) ranging from 170 8270 ng/g dry weight (dw) (median: 746 dw). were dominant among the four classes analyzed, accounting for 49% ∑All, followed by DDACs (40%), BACm (9%), ATMACs (2%). In urine, only ω-carboxyl (COOH−) frequently found, with a median concentration ∑BACm 0.49 ng/mL. measured exhibited positive correlations, suggestive usage these chemicals mixture. The cumulative daily intakes (CDIs) calculated based on QAC feces, through reverse dosimetry approach. average CDI was estimated be 551 ng/kg body (BW)/day adults, which 3 orders magnitude below toxicity reference dose (RfD) suggested (0.44 mg/kg BW/day) (0.1 BW/day). This study provides important quantitative information about exposure fecal elimination QACs.

Language: Английский

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Revolutionizing developmental neurotoxicity testing – a journey from animal models to advanced in vitro systems

ALTEX, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Developmental neurotoxicity (DNT) testing has seen enormous progress over the last two decades. Preceding even publication of animal-based OECD test guideline for DNT in 2007, a series non-animal technology workshops and conferences (starting 2005) shaped community that delivered comprehensive battery vitro methods (IVB). Its data interpretation is covered by very recent guidance (No. 377). Here, we aim to overview field, focusing on evolution strategies, role emerging technologies, impact guidelines testing. In particular, this an example targeted development animal-free approach one most complex hazards chemicals human health. These developments started literally from blank slate, with no proposed alternative available. Over decades, cutting-edge science enabled design spares animals enables throughput challenging hazard. While it evident field needs regulation, massive economic decreased cognitive capacity caused chemical exposure should be prioritized more highly. Beyond this, claim fame scientific brought understanding brain, its development, how can perturbed. Plain language summaryDevelopmental predicts hazard brain development. Comprehensive advanced strategies using now replace approaches assess large numbers accurately efficiently than approach. Recent formalized DNT, marking pivotal achievement field. The shift towards reflects both commitment animal welfare growing recognition public health impacts associated impaired function exposures. innovations ultimately contribute safer management better protection health, especially during vulnerable stages

Language: Английский

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Structure-dependent destructive adsorption of organophosphate flame retardants on lipid membranes

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 478, P. 135494 - 135494

Published: Aug. 12, 2024

Language: Английский

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Elevated Concentrations of Quaternary Ammonium Compounds in Childcare Centers: A Pilot Study

Journal of Hazardous Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 100138 - 100138

Published: Jan. 1, 2025

Language: Английский

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Environmental Safety Perspectives on Organophosphate Flame Retardants: Current strategies and advancements in their environmental removal and detection

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115340 - 115340

Published: Jan. 1, 2025

Language: Английский

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An Enhanced Protocol to Expand Human Exposome and Machine Learning-Based Prediction for Methodology Application

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

The human exposome remains limited due to the challenging analytical strategies used reveal low-level endocrine-disrupting chemicals (EDCs) and their metabolites in serum urine. This limits integrity of EDC exposure assessment hinders understanding cumulative health effects. In this study, we propose an enhanced protocol based on multi-solid-phase extraction (multi-SPE) expand with polar EDCs train a machine learning (ML) model for methodology prediction molecular descriptors. measurement 70 (25%) 34 (12%) out 295 well-acknowledged urine compared hydrophilic–lipophilic balance sorbent alone. nontarget analysis from 20 women childbearing age cohort 498, controlling occupational factors daily behaviors high chemical potential, multi-SPE increased 10 (40%) 16 (53%) target identification 17 (77%) (36%) (confidence ≥ level 3) urine, respectively. Interestingly, ML predicted that could identify additional 38% most bioactive chemicals. conclusion, advances by expanding profiles.

Language: Английский

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Glioma mutational signatures associated with haloalkane exposure are enriched in firefighters

Cancer, Journal Year: 2025, Volume and Issue: 131(6)

Published: March 10, 2025

Glioma is the most common malignant primary brain tumor and associated with significant morbidity mortality. Modifiable risk factors remain unidentified. New advances in exposure assessment, genomic analyses, statistical techniques permit more accurate evaluation of glioma exogenous occupational or environmental exposures. By using whole-exome sequencing data from matched germline samples, authors compared mutational signatures for 17 persons a documented history firefighting those 18 without an firefighting. All 35 individuals were participants University California, San Francisco Adult Study. There was positive correlation among firefighters between median number sample variants attributable to single-base substitution signature 42, haloalkane (from Catalogue Somatic Mutational Signatures Cancer) years (p = .04; R2 0.29). Among nonfirefighters, highest 42 also had occupations that possibly exposed them haloalkanes, such as painting being mechanic. In summary, identified gliomas enriched other occupations.

Language: Английский

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Trimester-specific associations of exposure to epoxide alkanes, alkenals, and 1,3-butadiene with preschool children’s intellectual development: A birth cohort study in Wuhan, China

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109456 - 109456

Published: April 1, 2025

Language: Английский

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