Reply to: A curious concept of CNS clearance DOI
Nicholas P. Franks, William Wisden

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Sleep on it! DOI Creative Commons
Laurent Sheybani

Brain Communications, Journal Year: 2025, Volume and Issue: 7(2)

Published: Jan. 1, 2025

Our Associate Editor, Laurent Sheybani, discusses some very old and recent findings on sleep physiology function, hoping to raise further interest publications in the field.

Language: Английский

Citations

0

The night’s watch: Exploring how sleep protects against neurodegeneration DOI Creative Commons
Samira Parhizkar, David M. Holtzman

Neuron, Journal Year: 2025, Volume and Issue: 113(6), P. 817 - 837

Published: March 1, 2025

Sleep loss is often regarded as an early manifestation of neurodegenerative diseases given its common occurrence and link to cognitive dysfunction. However, the precise mechanisms by which sleep disturbances contribute neurodegeneration are not fully understood, nor it clear why some individuals more susceptible these effects than others. This review addresses critical unanswered questions in field, including whether precede or result from diseases, functional significance changes during preclinical disease phase, potential role homeostasis adaptive mechanism enhancing resilience against decline neurodegeneration.

Language: Английский

Citations

0

Dual orexin receptor antagonists as promising therapeutics for Alzheimer’s disease DOI Creative Commons

Sydney M. Ragsdale,

John M. Radovich,

Isabel I. Coiduras

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: March 8, 2025

We examine the relationship between sleep, glymphatics and Alzheimer's disease (AD), recent work questioning glymphatic clearance during sleep. highlight a need for understanding and/or other mechanism of review flow measurement methods. Further, we explore dual orexin receptor antagonists (DORAs) potential to mitigate AD sleep disturbances enhance clearance. Further research could elucidate linkage DORAs, improved reducing pathophysiology.

Language: Английский

Citations

0

Mechanistic insights into the interaction between epilepsy and sleep DOI
Laurent Sheybani, Birgit Frauscher, Christophe Bernard

et al.

Nature Reviews Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0

Reply to: A curious concept of CNS clearance DOI
Nicholas P. Franks, William Wisden

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Citations

0