Engineering, Journal Year: 2024, Volume and Issue: 44, P. 73 - 86
Published: Dec. 20, 2024
Language: Английский
Trends in Cognitive Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
1
ACS Omega, Journal Year: 2025, Volume and Issue: 10(10), P. 10733 - 10740
Published: March 10, 2025
Neural probes capable of the precise recording and control brain signals are essential tools for brain-computer interfaces neuroscience research. However, conventional neural have not been widely adopted due to high costs associated with semiconductor fabrication complex packaging procedures. Herein, we present a breakthrough in this area form highly efficient flexible probe production cost only 1.5 dollars per unit that can be mass-produced (1000 units within 3 days). The design is based on standardized printed circuit board (PCB) process ensures large-scale producibility minimizes device performance variation. features four independent enable targeting multiple regions reusable interface PCB complexity. signal fabricated comparable traditional silicon-based scalable eight electrodes simultaneous measurements. We anticipate our innovative will significantly improve accessibility
Language: Английский
Citations
1
npj Flexible Electronics, Journal Year: 2025, Volume and Issue: 9(1)
Published: May 8, 2025
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 5, 2025
Abstract The ability to measure changes in neural activities using devices implanted the brain can be useful for recording signals assess specific risk factors, monitor development of diseases, and expand understanding circuitry. Here, a neuroimplantable interface is introduced that integrates biomaterials with an advanced structural design facilitate monitoring electrophysiological responses widespread regions. uses biocompatible photopatternable materials create ultrathin, homogeneous encapsulant/substrate laminates. Comprehensive vitro tests laminin‐enveloped demonstrate efficacy relieving inflammation via biomimetic strategy by diminishing microglia astrocyte aggregation near sites, enhancing periodic signal acquisition. performance evaluated injecting acetylcholine receptor agonist into mouse brains. This approach enables real‐time changes, gain insights network dynamics assessing stimulus‐evoked signaling at identify patterns hippocampal synaptic connections. Additionally, Parkinson's disease model, deep stimulation performed are recorded confirm symptom amelioration, offering biomedical device approach. key highlights intact electrodes biocompatible, mechanically compliant conferring compact bioelectronic functionalities, high neuronal microenvironment compatibility, pathological system recognition.
Language: Английский
Citations
0
Cyborg and Bionic Systems, Journal Year: 2025, Volume and Issue: 6
Published: Jan. 1, 2025
Primates possess a more developed central nervous system and higher level of intelligence than rodents. Detecting modulating deep brain activity in primates enhances our understanding neural mechanisms, facilitates the study major diseases, enables brain–computer interactions, supports advancements artificial intelligence. Traditional imaging methods such as magnetic resonance imaging, positron emission computed tomography, scalp electroencephalogram are limited spatial resolution. They cannot accurately capture signals from individual neurons. With progress microelectromechanical systems other micromachining technologies, single-neuron detection stimulation technology rodents based on microelectrodes has made important progress. However, compared with rodents, human nonhuman have larger volume that needs deeper implantation depth, test object safety device preparation requirements. Therefore, high-resolution devices suitable for long-term brains urgently needed. This paper reviewed electrode array used electrophysiological electrochemical detections primates’ brains. The research recording technologies was introduced perspective type structures, their potential value neuroscience clinical disease treatments discussed. Finally, it is speculated future electrodes will lot room development terms flexibility, high resolution, brain, throughput. improvements forms process expand activities, bring new opportunities challenges further neuroscience.
Language: Английский
Citations
0
Science China Technological Sciences, Journal Year: 2025, Volume and Issue: 68(5)
Published: April 8, 2025
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: April 19, 2025
SUMMARY Monitoring neural population activity at single-cell resolution is essential for driving fundamental research and clinical innovations. However, translating advanced recording techniques from animal models to humans remains a significant challenge. Flexible electrodes have recently emerged as powerful tools large-scale single-unit recordings due their superior biocompatibility high density. Here, we demonstrate reliable, high-density during intraoperative procedures in human patients using u ltra- F lexible I mplantable N eural E lectrode (uFINE) arrays. The uFINE array exhibited sufficient mechanical robustness maintain structural integrity throughout surgical operations. We successfully recorded 616 single units 10 patients, with up 135 simultaneously recorded. flexibility of minimized signal disturbances brain pulsations, enabling stable continuous detection. Stimulus response tuning were observed the level individual neurons awake patients. This uFINE-based approach offers unique opportunities investigate human-specific cognitive functions develop next-generation brain-machine interfaces.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 28, 2025
Abstract Brain‐computer interfaces (BCIs) hold the potential to revolutionize brain function restoration, enhance human capability, and advance our understanding of cognitive mechanisms by directly linking neural signals with hardware. However, mechanical mismatch between conventional rigid BCIs soft tissue limits long‐term interface stability. Next‐generation must achieve biocompatibility while maintaining high performance, enabling integration millions sensors within tissue‐level flexible soft, stable interfaces. Lithographic fabrication techniques provide scalable thin‐film electronics, but traditional electronic materials often fail meet unique requirements BCIs. This review examines selection device design for BCIs, starting an analysis intrinsic material properties—Young's modulus, electrical conductivity dielectric constant. It then explores electrode optimize circuits assess key factors. Next, correlation performance is analyzed guide design. Finally, recent advances in probes are reviewed, highlighting improvements signal quality, recording stability, scalability. focuses on scalable, lithography‐based aiming identify optimal designs long‐term, reliable recordings.
Language: Английский
Citations
0
Nature Reviews Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0
Cell Reports Methods, Journal Year: 2025, Volume and Issue: unknown, P. 101034 - 101034
Published: May 1, 2025
Language: Английский
Citations
0