Geneticsbiologiesingle cell and expression analysis for erectile dysfunction and cervical cancer targets DOI Creative Commons

Tengfei Zhao,

Yangyang Li,

Huixue Liu

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 21, 2024

Sexual dysfunction and cervical cancer are genetically molecularly two complex health problems. Here, we integrate genetic inference single-cell expression analysis to identify potential targets for sexual cancer, assess causality of these utilizing Mendelian randomization approaches. We performed a genome-wide association study (GWAS) variants associated with cancer. Next, examined the cellular landscape variation regions based on scRNAseq data. The identified several that correlated respectively, differentially expressed in reproductive cells. Two-Gene Combination Panel Increased WISP1 gene was detected tissues. Twas most highly T cells, least well- when cells were proliferating. integrates genetics nominate establishes causal support from approach.

Language: Английский

Genetic targeting of myelinated primary afferent neurons using a new NefhCreERT2 knock-in mouse DOI Creative Commons
Joseph C. Y. Chen, Lech Kaczmarczyk, Felipe Meira de‐Faria

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 29, 2025

Abstract Primary afferent neurons that convey somatosensory modalities comprise two large, heterogeneous populations: small-diameter give rise to slowly conducting unmyelinated axonal C fibers and medium-to-large diameter with fast myelinated A fibers. Despite these major groupings, tools differentiate between primary by genetic targeting have not been available; in particular, whereas numerous mouse driver lines exist target different fiber populations, populations are scarce. Here we describe a knock-in line expressing tamoxifen-dependent CreERT2 under control of the Nefh gene, which encodes neurofilament heavy chain (NFH or NF200), protein is highly enriched This enables selective efficient recombination Cre-dependent reporters for functional anatomical interrogation while excluding In combination other recombinase-expressing lines, this tool will be valuable intersectional subpopulations

Language: Английский

Citations

0
Atypical brain function hierarchy in autism spectrum disorder: insights from a novel analytical approach based on neuronal oscillation pattern DOI
Yunge Zhang, Huanjie Li, Wenyu Gu

et al.

European Child & Adolescent Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: May 17, 2025

Language: Английский

Citations

0
Geneticsbiologiesingle cell and expression analysis for erectile dysfunction and cervical cancer targets DOI Creative Commons

Tengfei Zhao,

Yangyang Li,

Huixue Liu

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 21, 2024

Sexual dysfunction and cervical cancer are genetically molecularly two complex health problems. Here, we integrate genetic inference single-cell expression analysis to identify potential targets for sexual cancer, assess causality of these utilizing Mendelian randomization approaches. We performed a genome-wide association study (GWAS) variants associated with cancer. Next, examined the cellular landscape variation regions based on scRNAseq data. The identified several that correlated respectively, differentially expressed in reproductive cells. Two-Gene Combination Panel Increased WISP1 gene was detected tissues. Twas most highly T cells, least well- when cells were proliferating. integrates genetics nominate establishes causal support from approach.

Language: Английский

Citations

0