Congruent neuronal modulation across competing actions challenges the role of the substantia nigra in action selection DOI Open Access
Lingfeng Hou, S. Torres, Daniel Svedberg

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

The basal ganglia are involved in the control of movement, but their exact role is unclear. Paradoxically, most inhibitory projection neurons main output nuclei increase firing around time movement; only a small fraction decrease firing. This antagonistic activity pattern could subserve action selection, with "decrease" population selectively disinhibiting desired and larger "increase" inhibiting competing movements. action-selection hypothesis makes an implicit assumption: that to disinhibit specific should inhibit when different desired. To test this hypothesis, we recorded substantia nigra pars reticulata (SNr) mice trained alternate between two types Many SNr showed "ramping" pre-movement firing-rate modulation, increasing firing, consistent previous findings. However, contrary model, overwhelming majority exhibited congruent modulation actions, either or decreasing rates for both actions; opposite signs modulation. We not ascribe potential uninstructed Our results easily reconciled simple mechanisms selection nuclei. also found ramping typically began hundreds ms before self-timed spontaneous movements, contrast findings suggesting modulated too late be movement initiation. suggest constraints - raise new questions about initiation selection.

Language: Английский

Congruent neuronal modulation across competing actions challenges the role of the substantia nigra in action selection DOI Open Access
Lingfeng Hou, S. Torres, Daniel Svedberg

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

The basal ganglia are involved in the control of movement, but their exact role is unclear. Paradoxically, most inhibitory projection neurons main output nuclei increase firing around time movement; only a small fraction decrease firing. This antagonistic activity pattern could subserve action selection, with "decrease" population selectively disinhibiting desired and larger "increase" inhibiting competing movements. action-selection hypothesis makes an implicit assumption: that to disinhibit specific should inhibit when different desired. To test this hypothesis, we recorded substantia nigra pars reticulata (SNr) mice trained alternate between two types Many SNr showed "ramping" pre-movement firing-rate modulation, increasing firing, consistent previous findings. However, contrary model, overwhelming majority exhibited congruent modulation actions, either or decreasing rates for both actions; opposite signs modulation. We not ascribe potential uninstructed Our results easily reconciled simple mechanisms selection nuclei. also found ramping typically began hundreds ms before self-timed spontaneous movements, contrast findings suggesting modulated too late be movement initiation. suggest constraints - raise new questions about initiation selection.

Language: Английский

Citations

0