Dopaminergic action prediction errors serve as a value-free teaching signal DOI Creative Commons
Francesca Greenstreet, Hernando Martínez Vergara, Yvonne Johansson

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Abstract Choice behaviour of animals is characterized by two main tendencies: taking actions that led to rewards and repeating past 1,2 . Theory suggests these strategies may be reinforced different types dopaminergic teaching signals: reward prediction error reinforce value-based associations movement-based action errors value-free repetitive 3–6 Here we use an auditory discrimination task in mice show movement-related dopamine activity the tail striatum encodes hypothesized signal. Causal manipulations reveal this serves as a signal supports learning reinforcing repeated associations. Computational modelling experiments demonstrate alone cannot support reward-guided learning, but when paired with circuitry they serve consolidate stable sound–action manner. Together there are work tandem each association striatal areas.

Language: Английский

A midbrain to ventral striatum dopaminergic pathway orchestrates odor-guided feeding on cotton bollworm larvae in mice DOI
Yun Feng Zhang,

Wenqiang Wang,

Yanbiao Zhong

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Abstract Interspecific interactions are crucial for maintaining ecological balance. Foraging and food consumption fundamental the survival of animals. In natural environments, wild rodents feed on various insect species, including moth larvae, odor-guided evaluation potential resources is a critical step in initiating feeding behavior. However, mechanisms by which seek prey remain poorly understood. Herein, we employed laboratory-based predator-prey interaction system using mice cotton bollworm larvae to investigate neural underlying food-seeking behaviors at both cellular circuit levels. We demonstrate that exhibit strong preference consuming fed this dependent main olfactory system. Gas chromatography-mass spectrometry (GC-MS) analysis revealed significant differences chemical profiles unfed with containing higher level linoleic acid (LA) lower (Z)-9-tricosene ((Z)-9-TE). Behavioral assays showed mice, as well Brand’s voles brown rats, attracted LA but avoid (Z)-9-TE two-choice odor test. Furthermore, identified dopaminergic pathway from ventral tegmental area (VTA) medial tubercle (mOT) plays central role mediating preference. Chemogenetic inhibition abolished over (Z)-9-TE, while chemogenetic activation reversed effect. Additionally, fiber photometry recordings pharmacology mOT D1 D2 spiny projection neurons (SPNs) preferentially mediate attraction avoidance respectively. These findings provide framework rodents’ forage complicated environment.

Language: Английский

Citations

0
Dopamine signals threat-coping behaviour in threat–reward conflicts DOI
Jake Rogers

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

0
Dopaminergic action prediction errors serve as a value-free teaching signal DOI Creative Commons
Francesca Greenstreet, Hernando Martínez Vergara, Yvonne Johansson

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Abstract Choice behaviour of animals is characterized by two main tendencies: taking actions that led to rewards and repeating past 1,2 . Theory suggests these strategies may be reinforced different types dopaminergic teaching signals: reward prediction error reinforce value-based associations movement-based action errors value-free repetitive 3–6 Here we use an auditory discrimination task in mice show movement-related dopamine activity the tail striatum encodes hypothesized signal. Causal manipulations reveal this serves as a signal supports learning reinforcing repeated associations. Computational modelling experiments demonstrate alone cannot support reward-guided learning, but when paired with circuitry they serve consolidate stable sound–action manner. Together there are work tandem each association striatal areas.

Language: Английский

Citations

0