Finding a needle in a haystack: functional screening for novel targets in cancer immunology and immunotherapies

Oncogene, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Genome-wide functional genetic screening has been widely used in the biomedicine field, which makes it possible to find a needle haystack at level. In cancer research, gene mutations are closely related tumor development, metastasis, and recurrence, use of state-of-the-art powerful technologies, such as clustered regularly interspaced short palindromic repeat (CRISPR), search for most critical genes or coding products provides us with new possibility further refine mapping provide possibilities treatment patients. The CRISPR refined atlas provided Immunotherapy, highly promising method, validated clinic, but could only meet needs small proportion Finding immunotherapy targets is key future immunotherapy. Here, we revisit application immunology from different perspectives, selection diverse vitro vivo models potential immune checkpoints potentiating CAR-T cells. data will offer fresh therapeutic clues

Language: Английский

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Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Designing drugs to intelligently respond different ratio of biological electron donors/receptors in cancer cells and normal is a promising strategy achieve highly effective less toxic chemotherapy. Herein by employing metal center active the selenium‐containing electrophilic drug Ru(phtpy‐NO 2 )(phenSe)Cl ( RuSe ) with strongly polarization characteristics are synthesized which can efficiently shuttle electrons from donors convert oxidative stress. The rate transfer at selenium 1.81 times higher cell environments compared environments. This results being 14.98 more lethal than cells. Experimental demonstrate that transport process carried out via radicals intermediate positively correlated properties atoms. transports bioactive generate large number superoxide anions leading DNA damage decrease mitochondrial membrane potential further activates p53 signaling pathway amplifies cell‐killing effect after transporting electrons. work provides new avenue for design efficient chemotherapeutic agents.

Language: Английский

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Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth

Cell Reports, Journal Year: 2025, Volume and Issue: 44(4), P. 115441 - 115441

Published: March 18, 2025

Language: Английский

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Borrow Strength to Exert: Low‐Crystallinity Prussian Blue for Reduction Overload Enhanced Photothermal Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract The strategy “Borrow strength to exert” in Sun Tzu's Art of War refers borrowing external forces withstand the enemy. Inspired by this, applying this thought cancer treatment can achieve a more efficient therapeutic effect. Therefore, fulcrum borrow force is vital and significant. Compared with normal cells, tumor cells are sensitive redox stress owing their abnormal metabolism. Herein, regulatory protocol based on chloroauric acid (HAuCl 4 ) proposed prepare small‐size low‐crystallinity Prussian blue nanoparticles (LcPB NPs). Notably, LcPB NPs possess higher superoxide dismutase (SOD)‐like enzyme activity induce reduction overload destroy metabolic processes organelle functions, which leverages status defect tumors as fulcrum. Due down‐regulation heat shock proteins (HSPs) mediated imbalance, inherent photothermal therapy (PTT) mode effectively inhibits growth disrupts calcium homeostasis. Additionally, improve anticancer effect inhibiting symbiotic bacteria. Meanwhile, magnetic optical response performance empowers resonance imaging (MRI) photoacoustic (PAI) for diagnosis. work executing “Borrowing disturbing balance represents new antineoplastic paradigm.

Language: Английский

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Identification of HES4 as a novel prognostic marker and therapeutic target in hepatocellular carcinoma

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 11, 2025

Hairy and enhancer of Split 4 (HES4) is thought to have a substantial impact on the pathogenesis progression malignancies. However, prognostic significance mechanism HES4 not been reported in Hepatocellular carcinoma (HCC). A comprehensive bioinformatics analysis expression, clinicopathological characteristics, tumor microenvironment status, drug sensitivity were performed based TCGA, GTEx, GEO. Paired HCC samples cell lines used validate dysfunction vitro. The expression at both mRNA protein levels was significantly upregulated tissues. High level associated with unfavorable outcomes. Enrichment demonstrated strong associations pathways. In addition, elevated positively correlated increased various chemotherapy drugs resistance immunotherapy. As transcription factor, target genes regulated by mostly risky genes, novel prediction model generated for risk stratification. AUCs 1-, 3-, 5-year year overall survival (OS) 0.829, 0.732, 0.700, respectively. overexpression poor clinical outcomes progression. may serve as marker therapeutic HCC.

Language: Английский

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Metabolic Pathway Analysis of Tumors Using Stable Isotopes

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 113, P. 9 - 24

Published: May 9, 2025

Language: Английский

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Integrator and U1 snRNPs steer Pol II in the right direction

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(6), P. 421 - 421

Published: May 10, 2024

Language: Английский

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