Improving translation of animal models of addiction and relapse by reverse translation

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(11), P. 625 - 643

Published: Oct. 6, 2020

Language: Английский

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Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review

Pharmacological Reviews, Journal Year: 2022, Volume and Issue: 74(1), P. 119 - 140

Published: Jan. 1, 2022

A widely held dogma in the preclinical addiction field is that females are more vulnerable than males to drug craving and relapse. Here, we first review clinical studies on sex differences psychostimulant opioid Next, reinstatement of seeking after extinction self-administration, incubation (time-dependent increase during abstinence). We also discuss ovarian hormones' role relapse humans animal models speculate brain mechanisms underlying their cocaine rodent models. Finally, imaging responses cues stress men women.The results reviewed do not appear support notion women However, this conclusion tentative because most were correlational, sufficiently powered, a priori designed detect differences. Additionally, suggest stress. The provide evidence for stress-induced but cue- or cocaine-induced seeking. These modulated part by hormones. In contrast, available data relapse/reinstatement methamphetamine opioids

Significance Statement

This systematic summarizes Results

Language: Английский

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Chromosomal and gonadal sex have differing effects on social motivation in mice

Biology of Sex Differences, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 19, 2025

Language: Английский

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The protective effect of operant social reward on cocaine self-administration, choice, and relapse is dependent on delay and effort for the social reward

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 46(13), P. 2350 - 2357

Published: Aug. 16, 2021

Language: Английский

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Animal Models of Drug Relapse and Craving after Voluntary Abstinence: A Review

Pharmacological Reviews, Journal Year: 2021, Volume and Issue: 73(3), P. 1050 - 1083

Published: July 1, 2021

Relapse to drug use during abstinence is a defining feature of addiction. During the last several decades, this clinical scenario has been studied at preclinical level using classic relapse/reinstatement models in which seeking assessed after experimenter-imposed home-cage forced or extinction drug-reinforced responding self-administration chambers. To date, however, results from studies rat have yet result Food and Drug Administration–approved medications for relapse prevention. The reasons state affairs are complex multifaceted, but one potential reason that, humans, often self-imposed voluntary occurs either because negative consequences outweigh drug's rewarding effects availability nondrug alternative rewards that chosen over drug. Based on these considerations, we others recently developed abstinence, achieved by introducing adverse taking (punishment) (electric barrier) providing mutually exclusive choices between self-administered (palatable food social interaction). In review, provide an overview translationally relevant discuss recent neuropharmacological findings models. We also sex as biological variable, future directions, implications Our main conclusion mechanisms controlling different reinstatement extinction.

Significance Statement

This review describes rewards. discusses directions implications.

Language: Английский

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Neural circuits regulating prosocial behaviors

Neuropsychopharmacology, Journal Year: 2022, Volume and Issue: 48(1), P. 79 - 89

Published: June 14, 2022

Language: Английский

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Abstinence-dependent dissociable central amygdala microcircuits control drug craving

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(14), P. 8126 - 8134

Published: March 23, 2020

We recently reported that social choice-induced voluntary abstinence prevents incubation of methamphetamine craving in rats. This inhibitory effect was associated with activation protein kinase-Cδ (PKCδ)-expressing neurons central amygdala lateral division (CeL). In contrast, after forced CeL-expressing somatostatin (SOM) neurons. Here we determined the causal role CeL PKCδ and SOM using short-hairpin RNAs against or developed validated. injected two groups shPKCδ shCtrl into trained them to lever press for interaction (6 d) then infusions (12 d). other shSOM assessed relapse seeking 1 15 days. Between tests, rats underwent either (shPKCδ groups) homecage (shSOM groups). After test day 15, SOM, Fos, double-labeled expression medial (CeM). injections decreased Fos PKCδ-expressing neurons, increased CeM output reversed on incubated drug 15. SOM-expressing Our results identify dissociable mechanisms abstinence-dependent inhibition craving.

Language: Английский

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Factors modulating the incubation of drug and non-drug craving and their clinical implications

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 131, P. 847 - 864

Published: Sept. 28, 2021

Language: Английский

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Characterization of operant social interaction in rats: effects of access duration, effort, peer familiarity, housing conditions, and choice between social interaction vs. food or remifentanil

Psychopharmacology, Journal Year: 2022, Volume and Issue: 239(7), P. 2093 - 2108

Published: March 1, 2022

Language: Английский

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An operant social self-administration and choice model in mice

Nature Protocols, Journal Year: 2023, Volume and Issue: 18(6), P. 1669 - 1686

Published: March 24, 2023

Language: Английский

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