Magnetic Hyperthermia to Promote Acrylamide Radical Polymerizations DOI
Marta Vassallo, Marta Vicentini, Martina Salzano de Luna

et al.

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(8), P. 4696 - 4707

Published: April 4, 2024

Radical polymerization is widely employed for the preparation of advanced materials with controlled properties and responsiveness. Depending on radical initiator, different stimuli can trigger beginning reaction. This work presents an innovative approach that exploits heat released by magnetic nanoparticles when they are excited alternating current (AC) field to induce polymerizations. In particular, use cobalt ferrite (CoFe2O4) explored polyacrylamide hydrogels, chosen as a model material demonstrate strategy. Magnetic mechanical characterizations reveal possess similar those samples prepared classical thermal polymerization. Indeed, hyperthermia versatile tool remote temperature control in localized space have applications. An example represented its selective volume thermosensitive environment, overcoming problems both bulk (e.g., not applicable delicate environments) photopolymerization poor light penetration). The obtained results pave way also production non-magnetic materials, which first concentrated small solution (by permanent magnet) then exploited activate whole AC field).

Language: Английский

Advances in engineering nanoparticles for magnetic particle imaging (MPI) DOI Creative Commons
Ambar C. Velazquez-Albino, Eric Daniel Imhoff, Carlos Rinaldi

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(2)

Published: Jan. 8, 2025

Magnetic particle imaging (MPI) is an emerging modality with exciting biomedical applications, such as cell tracking, blood pool imaging, and image-guided magnetic hyperthermia. MPI unique in that signal generated entirely by synthetic nanoparticle tracers, motivating precise engineering of properties including size, shape, composition, coating to address the needs specific applications. However, success many applications clinical transition requires development high-sensitivity high-resolution for which there considerable room improvement. This review summarizes recent advancements tracer synthesis compares reported tracers terms sensitivity resolution. In making these comparisons, we point out inconsistencies reporting properties. To overcome this challenge, propose a list standardize characterization new improve communication within field.

Language: Английский

Citations

3
Magnetic Field‐Directed Deep Thermal Therapy via Double‐Layered Microneedle Patch for Promoting Tissue Regeneration in Infected Diabetic Skin Wounds DOI
Dengfeng He, Xingmou Liu,

Jiezhi Jia

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(2)

Published: Oct. 27, 2023

Abstract Although near‐infrared (NIR) light‐based photothermal therapies have shown therapeutic potential for infected wounds, the attenuation of NIR light intensity in tissue has severely limited usage deep bacterial infections. Herein, magneto‐thermal responsive bilayer microneedles (Fe‐Se‐HA MNs) consisting functionalized hyaluronic acid (HA), ferro‐ferric oxide (Fe 3 O 4 ), and micelle‐protected selenium nanoparticles (SeNPs@LAS) are constructed to overcome this challenge based on a self‐designed disk‐shaped electromagnetic field device (Disk‐ZVS). The generated by Disk‐ZVS shows virtually no living tissue. Finite element simulations showed that loss concentrated tips Fe‐Se‐HA MNs. MNs able puncture hard scabs, penetrate into biofilms, perform effective magnetic‐thermal conversion hyperthermia sterilization. Following, can be gradually degraded excessive hyaluronidase diabetic wound release SeNPs, which reduce reactive oxygen species (ROS) regulate redox homeostasis. Meanwhile, SeNPs beneficial angiogenesis, facilitates blood vessel formation promotes repair. Therefore, various functions achieved MNs, such as disinfection, non‐invasive penetration, anti‐inflammation, pro‐angiogenesis, great an adjunctive therapy wounds.

Language: Английский

Citations

41
A Paramagnetic Metal‐Organic Framework Enhances Mild Magnetic Hyperthermia Therapy by Downregulating Heat Shock Proteins and Promoting Ferroptosis via Aggravation of Two‐Way Regulated Redox Dyshomeostasis DOI Creative Commons
Yi Wang,

Zelong Chen,

Jiahui Li

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(11)

Published: Dec. 31, 2023

Abstract Mild magnetic hyperthermia therapy (MMHT) holds great potential in treating deep‐seated tumors, but its efficacy is impaired by the upregulation of heat shock proteins (HSPs) during treatment process. Herein, Lac‐FcMOF, a lactose derivative (Lac‐NH 2 ) modified paramagnetic metal‐organic framework (FcMOF) with property and thermal stability, has been developed to enhance MMHT therapeutic efficacy. In vitro studies showed that Lac‐FcMOF aggravates two‐way regulated redox dyshomeostasis (RDH) via magnetothermal‐accelerated ferricenium ions‐mediated consumption glutathione ferrocene‐catalyzed generation ∙OH induce oxidative damage inhibit protein 70 (HSP70) synthesis, thus significantly enhancing anti‐cancer MMHT. Aggravated RDH promotes peroxidase 4 inactivation lipid peroxidation promote ferroptosis, which further synergizes H22‐tumor‐bearing mice treated under alternating field (AMF) demonstrated 90.4% inhibition tumor growth. This work therefore provides new strategy for simple construction agent enables efficient downregulating HSPs promoting ferroptosis through aggravation RDH.

Language: Английский

Citations

33
Smart chemistry and applied perceptions of enzyme-coupled nano-engineered assemblies to meet future biocatalytic challenges DOI
Ayesha Anwar, Muhammad Imran, Hafiz M.N. Iqbal

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 493, P. 215329 - 215329

Published: July 9, 2023

Language: Английский

Citations

27
Minimally Invasive Delivery of Percutaneous Ablation Agent via Magnetic Colloidal Hydrogel Injection for Treatment of Hepatocellular Carcinoma DOI

Wenshu Wu,

Xu Yan, Sheng Chen

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: March 6, 2024

Percutaneous thermotherapy, a minimally invasive operational procedure, is employed in the ablation of deep tumor lesions by means target-delivering heat. Conventional thermal methods, such as radiofrequency or microwave ablation, to certain extent, are subjected extended time well biosafety risks unwanted overheating. Given its effectiveness and safety, percutaneous thermotherapy gains fresh perspective, thanks magnetic hyperthermia. In this respect, an injectable- magnetic-hydrogel-construct-based agent likely be candidate for aforementioned clinical translation. Adopting simple environment-friendly strategy, colloidal hydrogel injection introduced binary system comprising super-paramagnetic Fe

Language: Английский

Citations

15
Imaging-guided precision hyperthermia with magnetic nanoparticles DOI
Ali Shakeri‐Zadeh, Jeff W. M. Bulte

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 3(3), P. 245 - 260

Published: Nov. 7, 2024

Language: Английский

Citations

11
Magnetic nanoparticle-mediated hyperthermia: From heating mechanisms to cancer theranostics DOI Creative Commons
Shihao Bai, Shiying Hou, Tianxiang Chen

et al.

The Innovation Materials, Journal Year: 2024, Volume and Issue: 2(1), P. 100051 - 100051

Published: Jan. 1, 2024

<p>Magnetic nanoparticle-mediated hyperthermia (MHT) is a promising tumor theranostic technology due to its noninvasive nature and ability penetrate deep tissues without greatly damaging normal tissues. To advance the clinical translation application of MHT, we present comprehensive overview topics related including basic physical heating principles, magnetic nanoparticle design, biological effects applications. First, fundamental principles through which nanoparticles mediate are reviewed in detail. Subsequently, strategies increase magnetothermal effect MHT highlighted. Then, multitechnology integration applications precision diagnosis treatment introduced. Finally, key challenges outlooks for purposes discussed.</p>

Language: Английский

Citations

9
Iron oxide nanoparticles: The versatility of the magnetic and functionalized nanomaterials in targeting drugs, and gene deliveries with effectual magnetofection DOI
Salim Albukhaty, Ghassan M. Sulaiman, Hassan Al-Karagoly

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105838 - 105838

Published: June 3, 2024

Language: Английский

Citations

9
Magnetic–Plasmonic Nanocomposites as Versatile Substrates for Surface–enhanced Raman Scattering (SERS) Spectroscopy DOI Creative Commons
Ecem Tiryaki, Tolga Zorlu, Ramón A. Álvarez‐Puebla

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(24)

Published: Jan. 31, 2024

Surface-enhanced Raman scattering (SERS) spectroscopy, a highly sensitive technique for detecting trace-level analytes, relies on plasmonic substrates. The choice of substrate, its morphology, and the excitation wavelength are crucial in SERS applications. To address advanced requirements, design use efficient nanocomposite substrates have become increasingly important. Notably, magnetic-plasmonic (MP) nanocomposites, which combine magnetic properties within single particle system, stand out as promising nanoarchitectures with versatile applications nanomedicine spectroscopy. In this review, we present an overview MP fabrication methods, explore surface functionalization strategies, evaluate their SERS. Our focus is how different designs, properties, modifications can significantly influence SERS-related characteristics, thereby affecting performance specific such separation, environmental monitoring, biological Reviewing recent studies highlights multifaceted nature these materials, great potential to transform across range fields, from medical diagnostics monitoring. Finally, discuss prospects anticipating favorable developments that will make substantial contributions various scientific technological areas.

Language: Английский

Citations

8
From 0D to 2D: Synthesis and bio-application of anisotropic magnetic iron oxide nanomaterials DOI Creative Commons
Fuqiang Chang, Gemma‐Louise Davies

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 144, P. 101267 - 101267

Published: Feb. 29, 2024

Magnetic iron oxide nanoparticles (MIPs) have garnered significant scientific interest due to their magnetic properties and unique features, including low toxicity, colloidal stability, surface engineering capability. Recent advances in nanoparticle synthesis enabled the development of MIPs with precise control over physicochemical properties, making them suitable for medical applications. Anisotropic demonstrated shape-dependent performance various bio-applications, leading increased research moving from traditional zero-dimensional (0D) morphology towards one-dimensional (1D) two-dimensional (2D) topology. While these anisotropic materials offer enhanced specific applications, a critical systematic comparison anisotropy effects is lacking literature. This review seeks fill this current gap literature provides comprehensive summary last two decades on different shapes biomedical The paper will discuss theoretical mechanisms effects, primary synthetic approaches 0D, 1D, 2D MIP materials, biological behaviors. In addition, identifies challenges open questions that need be addressed. proposed directions outlined potential revitalize use "old" future (MIPs), Anisotropic, Shape-dependent, Zero-dimensional (0D), (1D), (2D), MRI, hyperthermia, bioapplication.

Language: Английский

Citations

8