Genome biology,
Journal Year:
2021,
Volume and Issue:
22(1)
Published: Jan. 4, 2021
Abstract
Background
Long-read
sequencing
of
full-length
cDNAs
enables
the
detection
structures
aberrant
splicing
isoforms
in
cancer
cells.
These
are
occasionally
translated,
presented
by
HLA
molecules,
and
recognized
as
neoantigens.
This
study
used
a
long-read
sequencer
(MinION)
to
construct
comprehensive
catalog
non-small-cell
lung
cancers,
which
novel
potential
neoantigens
identified.
Results
Full-length
cDNA
is
performed
using
22
cell
lines,
total
2021
The
protein
expression
some
these
then
validated
proteome
analysis.
Ablations
nonsense-mediated
mRNA
decay
(NMD)
factor,
UPF1,
SF3B1,
found
increase
proportion
transcripts.
NetMHC
evaluation
binding
affinities
each
type
molecule
reveals
that
potentially
generate
neoantigen
candidates.
We
also
identify
seven
specimens.
An
enzyme-linked
immune
absorbent
spot
assay
indicates
approximately
half
peptide
candidates
have
activate
T
responses
through
their
interaction
with
molecules.
Finally,
we
estimate
number
Cancer
Genome
Atlas
(TCGA)
datasets
referring
constructed
disruption
NMD
factors
significantly
correlated
TCGA-Lung
Adenocarcinoma
data
collection.
Conclusions
Our
results
indicate
essential
for
precise
identification
transcript
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
31(7)
Published: Dec. 27, 2018
Together
with
the
evolution
of
digital
health
care,
wearable
electronics
field
has
evolved
rapidly
during
past
few
years
and
is
expected
to
be
expanded
even
further
within
first
next
decade.
As
stage
wearables
predicted
move
toward
integrated
wearables,
nanomaterials
nanocomposites
are
in
spotlight
search
for
novel
concepts
integration.
In
addition,
conversion
current
devices
attachment-based
into
technology
may
involve
a
significant
size
reduction
while
retaining
their
functional
capabilities.
Nanomaterial-based
sensors
have
already
marked
presence
distinction
nanomaterial-based
actuators
still
at
embryonic
stage.
This
review
looks
contribution
focus
on
actuators.
Biology,
Journal Year:
2019,
Volume and Issue:
8(3), P. 54 - 54
Published: July 12, 2019
The
Munich
ChronoType
Questionnaire
(MCTQ)
has
now
been
available
for
more
than
15
years
and
its
original
publication
cited
1240
times
(Google
Scholar,
May
2019).
Additionally,
online
version,
which
was
until
July
2017,
produced
almost
300,000
entries
from
all
over
the
world
(MCTQ
database).
MCTQ
gone
through
several
versions,
translated
into
13
languages,
validated
against
other
objective
measures
of
daily
timing
in
independent
studies.
Besides
being
used
as
a
method
to
correlate
circadian
features
human
biology
with
factors—ranging
health
issues
geographical
factors—the
gave
rise
quantification
old
wisdoms,
like
“teenagers
are
late”,
new
concepts,
social
jetlag.
Some
MCTQ’s
simplicity
some
view
it
critically.
Therefore,
is
time
present
self-critical
on
MCTQ,
address
misunderstandings,
give
definitions
MCTQ-derived
chronotype
concept
Proceedings of the National Academy of Sciences,
Journal Year:
2019,
Volume and Issue:
116(30), P. 15086 - 15095
Published: July 8, 2019
Significance
Malaria
transmission
persists
even
when
mosquito
control
is
used
effectively.
This
“residual
transmission”
measures
all
forms
of
that
are
beyond
the
reach
standard
insecticidal
nets
and
indoor
residual
spraying
insecticides
optimally.
The
epidemiological
importance
time
day
mosquitoes
bite
how
much
this
contributes
to
unclear.
scale
problem
must
be
understood
demonstrate
need
for
outdoor
vector
tools.
An
additional
10.6
million
clinical
cases
malaria
predicted
annually
given
10%
higher
level
biting
observed
here.
Mosquito
species
behavior
data
together
with
people’s
resting
sleeping
patterns
needed
fully
measure
intervention
efficacy
accurately
quantify
transmission.
Cellular and Molecular Immunology,
Journal Year:
2020,
Volume and Issue:
17(9), P. 901 - 913
Published: July 29, 2020
Abstract
Mycobacterium
tuberculosis
(Mtb)
is
an
extremely
successful
intracellular
pathogen
that
causes
(TB),
which
remains
the
leading
infectious
cause
of
human
death.
The
early
interactions
between
Mtb
and
host
innate
immune
system
largely
determine
establishment
TB
infection
disease
development.
Upon
infection,
cells
detect
through
a
set
receptors
launch
range
cellular
events.
However,
these
defense
mechanisms
are
extensively
modulated
by
to
avoid
clearance.
In
this
review,
we
describe
emerging
role
cytosolic
nucleic
acid-sensing
pathways
at
–
interface
summarize
recently
revealed
circumvents
strategies
such
as
membrane
trafficking
integrity,
cell
death
autophagy.
addition,
discuss
newly
elucidated
manipulates
molecular
regulatory
machinery
immunity,
including
intranuclear
machinery,
ubiquitin
system,
intrinsic
components.
A
better
understanding
evasion
adopted
will
provide
new
insights
into
pathogenesis
contribute
development
more
effective
vaccines
therapies.
Nature Communications,
Journal Year:
2019,
Volume and Issue:
10(1)
Published: Feb. 12, 2019
Abstract
Crystal
phase
control
in
layered
transition
metal
dichalcogenides
is
central
for
exploiting
their
different
electronic
properties.
Access
to
metastable
crystal
phases
limited
as
direct
synthesis
challenging,
restricting
the
spectrum
of
reachable
materials.
Here,
we
demonstrate
solution
distorted
octahedrally
coordinated
structure
(1T’
phase)
WSe
2
nanosheets.
We
design
a
kinetically-controlled
regime
colloidal
enable
formation
phase.
1T’
branched
few-layered
nanosheets
are
produced
high
yield
and
reproducible
controlled
manner.
The
fully
convertible
into
semiconducting
2H
upon
thermal
annealing
at
400
°C.
metallic
nature
exhibited
by
an
enhanced
electrocatalytic
activity
hydrogen
evolution
reaction
compared
comparable
other
phases.
This
can
potentially
be
extended
materials
providing
access
Frontiers in Physiology,
Journal Year:
2018,
Volume and Issue:
9
Published: Aug. 23, 2018
Recently,
two
alternative
targets
in
insect
periphery
nerve
system
have
been
explored
for
environmentally-friendly
approaches
pest
management,
namely
odorant-binding
proteins
(OBPs)
and
odorant
receptors
(ORs).
Located
antennae,
OBPs
are
thought
to
be
involved
the
transport
of
odorants
ORs
specific
signal
transduction
behaviorally
active
odorants.
There
is
rich
information
on
OBP
binding
affinity
molecular
docking
bioactive
compounds
as
well
ample
3D
crystal
structures
due
feasible
production
recombinant
proteins.
Although
these
provide
excellent
opportunities
them
considered
control
a
tool
design
agents,
debates
their
specificity
represent
an
obstacle.
On
other
hand,
recently
functionally
characterized
with
increasing
evidence
specificity,
sensitivity
functional
roles
behaviors.
However,
major
barrier
use
semiochemical
discovery
lack
structures.
Thus,
not
analyzed
comparatively
together
so
far
feasibility
targets.
Here,
we
summarize
state
research
terms
its
application
management.
We
discuss
suitability
both
selection
toward
new
potent
semiochemicals.
argue
that
promising
can
used
identify
super-ligands
likely
present
nature
reduced
risk
resistance
development
than
pesticides
currently
agriculture.
massive
identification
through
RNA-seq
improved
measurements,
could
reconsidered
suitable
discovery.
