Short-chain fatty acids promote the effect of environmental signals on the gut microbiome and metabolome in mice DOI Creative Commons
Francesco Marrocco,

Mary Delli Carpini,

Stefano Garofalo

et al.

Communications Biology, Journal Year: 2022, Volume and Issue: 5(1)

Published: May 31, 2022

Abstract Gut microorganisms and the products of their metabolism thoroughly affect host brain development, function behavior. Since alterations plasticity cognition have been demonstrated upon motor, sensorial social enrichment housing conditions, we hypothesized that gut microbiota metabolome could be altered by environmental stimuli, providing part missing link among signals effects. In this preliminary study, metagenomic metabolomic analyses mice housed in different standard enriched, identify environment-specific microbial communities metabolic profiles. We show an enriched environment distinctive composition with a reduction bacterial richness biodiversity are characterized fingerprint increase formate acetate decrease bile salts. demonstrate treated mixture recapitulate some effects modulated enrichment, such as hippocampal neurogenesis, neurotrophin production, short-term cognitive behaviors, can further exploited to decipher mechanisms involved experience-dependent plasticity.

Language: Английский

The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health DOI Creative Commons

Bianca J. Parker,

Pamela A. Wearsch, A.C.M. Veloo

et al.

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: June 9, 2020

Alistipes is a relatively new genus of bacteria isolated primarily from medical clinical samples, although at low rate compared to other members the Bacteroidetes phylum, which are highly relevant in dysbiosis and disease. According taxonomy database The National Center for Biotechnology Information, consists thirteen species: A. finegoldii, putredinis, onderdonkii, shahii, indistinctus, senegalensis, timonensis, obesi, ihumii, inops, megaguti, provencensis, massiliensis. Although typically human gut microbiome various species this have been patients suffering appendicitis, abdominal rectal abscess. It possible that as spp. emerge, their identification samples may be underrepresented novel MS-TOF methods not fully capable discriminate distinct separate since it will require upgrading databases. In terms pathogenicity, there contrasting evidence indicating protective effects against some diseases, including liver fibrosis, colitis, cancer immunotherapy, cardiovascular contrast, studies indicate pathogenic colorectal associated with mental signs depression. Gut seems play role determining compositional abundance feces (e.g., nonalcoholic steatohepatitis, hepatic encephalopathy, fibrosis). Since recent sub-branch commonly chronic intestinal inflammation, narrative review illustrates emerging immunological mechanistic implications by correlate health.

Language: Английский

Citations

1192
Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders DOI
Judith Aron‐Wisnewsky, Chloé Vigliotti, Julia J. Witjes

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2020, Volume and Issue: 17(5), P. 279 - 297

Published: March 9, 2020

Language: Английский

Citations

787
RETRACTED ARTICLE: Role of the gut microbiome in chronic diseases: a narrative review DOI Creative Commons
Amrita Vijay, Ana M. Valdes

European Journal of Clinical Nutrition, Journal Year: 2021, Volume and Issue: 76(4), P. 489 - 501

Published: Sept. 28, 2021

Language: Английский

Citations

329
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis DOI Creative Commons
Tae Gyu Oh,

Susy M. Kim,

Cyrielle Caussy

et al.

Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(5), P. 878 - 888.e6

Published: June 30, 2020

Language: Английский

Citations

244
Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis DOI Open Access
Jasmohan S. Bajaj, Alexander Khoruts

Journal of Hepatology, Journal Year: 2020, Volume and Issue: 72(5), P. 1003 - 1027

Published: Jan. 28, 2020

Language: Английский

Citations

140
Hepatic encephalopathy DOI
Dieter Häussinger, Radha K. Dhiman, Vicente Felipo

et al.

Nature Reviews Disease Primers, Journal Year: 2022, Volume and Issue: 8(1)

Published: June 23, 2022

Language: Английский

Citations

134
Diet preference of zebrafish (Danio rerio) for bio-based polylactic acid microplastics and induced intestinal damage and microbiota dysbiosis DOI
Zhenghua Duan,

Haodong Cheng,

Xinyue Duan

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 429, P. 128332 - 128332

Published: Jan. 25, 2022

Language: Английский

Citations

105
Differences in Alpha Diversity of Gut Microbiota in Neurological Diseases DOI Creative Commons
Zhuoxin Li, Jie Zhou, Hao Liang

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: June 28, 2022

Neurological diseases are difficult to diagnose in time, and there is currently a lack of effective predictive methods. Previous studies have indicated that variety neurological cause changes the gut microbiota. Alpha diversity major indicator describe At present, relationship between alpha microbiota remains unclear.We performed systematic literature search Pubmed Bioproject databases up January 2021. Six indices were used measure diversity, including community richness (observed species, Chao1 ACE), (Shannon, Simpson), phylogenetic (PD). Random-effects meta-analyses on standardized mean difference (SMD) carried out indices. Subgroup analyses explore sources interstudy heterogeneity. Meta-analysis was articles by matching age, sex, body mass index (BMI) disease group with control group. Meanwhile, subgroup analysis variability sequencing region, platform, geographical instrument, diseases. The area under curve (AUC) value receiver operating characteristic (ROC) calculated assess prediction effectiveness microbial indices.We conducted meta-analysis 24 published 16S rRNA gene amplified from database (patients, n = 1,469; controls, 1,289). pooled estimate demonstrated no significant patients controls (P < 0.05). decreased only Parkinson's patients, while it increased anorexia nervosa compared controls. After adjusting for BMI, none associated In terms Illumina HiSeq 2000 V3-V5 results showed significantly comparison 2500. ROC curves suggested could be as biomarker predict AD (Simpson, AUC= 0.769, P 0.0001), MS 0.737, 0.001), schizophrenia (Chao1, AUC 0.739, 0.002).Our review summarized promising predictor AD, schizophrenia, MS, but not all

Language: Английский

Citations

94
Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases DOI Creative Commons
Susana Rodrigues, Van der Merwe, Aleksander Krag

et al.

Seminars in Immunology, Journal Year: 2024, Volume and Issue: 71, P. 101859 - 101859

Published: Jan. 21, 2024

Language: Английский

Citations

19
Targeting the gut-liver-immune axis to treat cirrhosis DOI
Thomas H. Tranah, Lindsey Edwards, Bernd Schnabl

et al.

Gut, Journal Year: 2020, Volume and Issue: 70(5), P. 982 - 994

Published: Oct. 15, 2020

Cirrhotic portal hypertension is characterised by development of the decompensating events ascites, encephalopathy, hypertensive bleeding and hepatorenal syndrome, which arise in a setting cirrhosis-associated immune dysfunction (CAID) define morbidity prognosis. CAID describes dichotomous observations that systemic cells are primed display an inflammatory phenotype, while failing to mount robust responses pathogen challenge. Bacterial infections including spontaneous bacterial peritonitis common complications advanced chronic liver disease can precipitate variceal haemorrhage, syndrome acute-on-chronic failure; they frequently from gut-derived organisms closely linked with dysbiosis commensal intestinal microbiota disease. Here, we review links between cirrhotic dysbiosis, barrier deficits host-microbiome compartmentalisation mucosal homoeostasis occur settings We discuss established emerging therapeutic strategies targeted at restoring eubiosis, augmenting gut function ameliorating characterise course decompensated cirrhosis.

Language: Английский

Citations

124