Harnessing the power of multi‐omics data for predicting climate change response DOI
Kara K S Layton, Ian Bradbury

Journal of Animal Ecology, Journal Year: 2021, Volume and Issue: 91(6), P. 1064 - 1072

Published: Oct. 22, 2021

Predicting how species will respond to future climate change is of central importance in the midst global biodiversity crisis, and recent work has demonstrated utility population genomics for improving these predictions. Here, we suggest a broadening approach include other types genomic variants that play an important role adaptation, like structural (e.g. copy number variants) epigenetic DNA methylation). These data could provide additional power forecasting response, especially weakly structured or panmictic species. Incorporating variation into estimates vulnerability, maladaptation, may not only improve prediction but also insight molecular mechanisms underpinning species' response change.

Language: Английский

Heat Stress and Histopathological Changes of Vital Organs: A Novel Approach to Assess Climate Resilience in Farm Animals DOI Open Access
Ebenezer Binuni Rebez, Veerasamy Sejian, M. V. Silpa

et al.

Sustainability, Journal Year: 2023, Volume and Issue: 15(2), P. 1242 - 1242

Published: Jan. 9, 2023

Heat stress causes functional and metabolic alterations in different cells tissues. There are several pathomorphological changes biomarkers associated with head load adaptive productive organs of livestock. stress-induced histopathological livestock were categorized as degenerative (fatty degeneration, steatosis, hydropic degeneration), necrosis (pyknosis, fibrosis), circulatory disturbances (hyperemia, edema, hemorrhage, congestion, thrombosis, ischemia), growth (hyperplasia, atrophy) focal/diffuse inflammation (vascular changes, exudation). Upon immunohistochemical analysis, the identified growth-related HSP70, HSP60, GABA, GABAAR, GABABR, HSP90, GnRH, LH, FSH, m6A, Nrf2, C/EBPβ. The reproductive Bax, Bcl-2, Caspase-3, HSPB9, HSPB10, HSF1, HSP40, T, E2, Cyt-C, CAT, BCL2L1, VEGF. immune CD3+ T cells, CD4+ CD8+ Bcl-2. All these could serve reliable variables heat assessment Further, NPY, HSP27, NF-κB, AQP2, Insulin, CD172a, EGF, AQP1, AQP3, AQP4, AQP5, CRYAB, GHR, 5-HT, CCK, GLP-1 stress-related that help assessing climate resilience a species improving understanding about mechanisms. Among biomarkers, HSP70 was established to be ideal cellular biomarker for scaling response Thus, examining heat-stressed organ histopathology identifying markers by immunohistochemistry may lay foundation screening climate-resilient breeds challenging climatic scenario. such an approach developing concepts combat detrimental consequences ensure sustainability production.

Language: Английский

Citations

18
An expert review of environmental heat exposure and stillbirth in the face of climate change: Clinical implications and priority issues DOI Creative Commons
Ana Bonell, Chérie Part, Uduak Okomo

et al.

BJOG An International Journal of Obstetrics & Gynaecology, Journal Year: 2023, Volume and Issue: 131(5), P. 623 - 631

Published: July 28, 2023

Abstract Exposure to extreme heat in pregnancy increases the risk of stillbirth. Progress reducing stillbirth rates has stalled, and populations are increasingly exposed high temperatures climate events that may further undermine health strategies. This narrative review summarises current clinical epidemiological evidence impact maternal exposure on risk. Out 20 studies, 19 found an association between Recent studies based low‐ middle‐income countries tropical settings add existing literature demonstrate all at Additionally, both short‐term whole‐pregnancy increase A definitive threshold effect not been identified, as most define above 90th centile usual temperature for population. Therefore, with exposures from low >12.64°C up >46.4°C. The pathophysiological pathways by which lead stillbirth, human animal include placental embryonic or fetal impacts. Although gaps remain research is needed characterise these mechanistic more detail, preliminary suggests epigenetic changes, alteration imprinted genes, congenital abnormalities, reduction blood flow, size function play a part. Finally, we explore this topic public perspective; discuss evaluate guidance minimising community. There limited pregnancy‐specific within heatwave planning, no evidence‐based interventions have established prevent poor outcomes. We highlight priority questions move forward field specifically note urgent need sustainable.

Language: Английский

Citations

16
PHYSIOLOGY SYMPOSIUM: Effects of heat stress during late gestation on the dam and its calf12 DOI
Sha Tao, G.E. Dahl, Jimena Laporta

et al.

Journal of Animal Science, Journal Year: 2019, Volume and Issue: 97(5), P. 2245 - 2257

Published: Feb. 7, 2019

Heat stress during late gestation in cattle negatively affects the performance of dam and its calf. This brief exposure to an adverse environment before parturition physiological responses, tissue development, metabolism, immune function her offspring, thereby limiting their productivity. During dry period a dairy cow, heat blunts mammary involution by attenuating apoptosis autophagic activity reduces subsequent cell proliferation, leading impaired milk production next lactation. Dairy cows early lactation that experience prepartum display reduced adipose mobilization lower degree insulin resistance peripheral tissues. Similar gland placental is as evidenced secretion hormones (e.g., estrone sulfate) cows, which partly explains fetal growth rate lighter birth weight calves. Compared with calves born dams are exposed evaporative cooling summer, noncooled maintain BW until 1 yr age, but stronger ability absorb glucose metabolic challenges postnatally. Immunity calves, both passive cell-mediated function, also prenatal stress, resulting increased susceptibility diseases postnatal life. In fact, heifers heat-stressed without have greater chance leaving herd puberty compared provided (12.2% vs. 22.7%). late-gestation yield at maturity first second lactations. Emerging evidence suggests alters microstructure exerts epigenetic alterations might explain, part,

Language: Английский

Citations

53
Carry over effects of late-gestational heat stress on dairy cattle progeny DOI Creative Commons
Bethany Dado-Senn, Jimena Laporta, G.E. Dahl

et al.

Theriogenology, Journal Year: 2020, Volume and Issue: 154, P. 17 - 23

Published: May 12, 2020

Language: Английский

Citations

41
Developmental programming of production and reproduction in dairy cows: II. Association of gestational stage of maternal exposure to heat stress with offspring's birth weight, milk yield, reproductive performance and AMH concentration during the first lactation period DOI

Mohammad Javad Mozaffari Makiabadi,

Mohammad Bafandeh,

Faramarz Gharagozlou

et al.

Theriogenology, Journal Year: 2023, Volume and Issue: 212, P. 41 - 49

Published: Sept. 2, 2023

Language: Английский

Citations

13
Omics approaches to understand impact of heat stress on semen quality and fertility in bovines DOI

Meenakshi Chitkara,

Ankita Gurao, Harsimran Kaur

et al.

Animal Reproduction Science, Journal Year: 2025, Volume and Issue: unknown, P. 107786 - 107786

Published: Jan. 1, 2025

Language: Английский

Citations

0
Le stress thermique environnemental dans l’espèce bovine : 3. Effets sur la reproduction DOI Creative Commons
Christian Hanzen, Pauline Delhez, Françoise Lessire

et al.

Revue d’élevage et de médecine vétérinaire des pays tropicaux, Journal Year: 2025, Volume and Issue: 78, P. 1 - 15

Published: Feb. 28, 2025

Contexte : L’augmentation régulière depuis plusieurs décennies de la température environnementale s’est accompagnée dans l’espèce bovine, notamment d’une diminution fertilité différentes régions du monde. Objectifs Cette revue littérature passe en les divers effets et leurs mécanismes sur aspects reproduction mâle femelle bovine. Méthode À partir base PubMed, cette concentrée un premier temps articles synthèse puis a été complétée par références des identifiés. Résultats La résulte stress thermique croissance folliculaire ovarienne, avec une incidence plus marquée follicules pré-antraux que antraux, l’ovocyte le corps jaune. Ces sont conséquence réduction d’oestradiol, progestérone, l’inhibine l’hormone lutéotrope (LH) ainsi l’augmentation celle folliculostimulante (FSH), modification gradients au niveau système génital n’étant pas non à exclure. Le est également responsable augmentation fréquence mortalité embryonnaire particulièrement durant première semaine gestation. L’exposition vaches gestation raccourcit durée, affecte placenta, modifie métabolisme vache lors sa lactation, altère son immunité exerce négatifs pondérale, développement mammaire folliculaire, longévité performances veau. Chez mâle, se traduit motilité anomalies morphologiques spermatozoïdes. Conclusions reconnaissance croissante reproductives bovins souligne nécessité pour responsables santé animale intégrer approches. Il essentiel mettre place stratégies visant atténuer impacts rentabilité élevages, d’autant influence épigénétique descendance mieux documentée.

Citations

0
Stress Responses to Changing Environmental Factors in the Domestic Animals: An Epigenetic Perspective DOI Creative Commons
Basavaraj Sajjanar, Narayanan Krishnaswamy, Vijay Kumar Saxena

et al.

Journal of Animal Physiology and Animal Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

ABSTRACT Extreme environmental variations act as stress factors that disturb homeostasis and reduce the fitness of animals. The outcomes responses range from acclimation to adaptation animals stressors. Gene expression patterns shape neuro‐endocrine cellular signalling involved in these responses. Epigenetic modifications are one major gene regulatory mechanisms connect animal response. dynamic well stable modes epigenetic changes carry memory regulation at transgenerational levels. In this review, we highlight involvement domestication process, an captive environment summarize recently identified regulate different factors. We underline possible role developmentally basis for fetal programming methods such thermal conditioning prenatal nutritional interventions. These examples indicate potential scope understanding regulations improving performance domestic

Language: Английский

Citations

0
Symposium review: Late-gestation maternal factors affecting the health and development of dairy calves DOI Creative Commons
Ángel Abuelo

Journal of Dairy Science, Journal Year: 2020, Volume and Issue: 103(4), P. 3882 - 3893

Published: Feb. 7, 2020

Language: Английский

Citations

38
Heat stress during late gestation disrupts maternal microbial transmission with altered offspring’s gut microbial colonization and serum metabolites in a pig model DOI
Jianwen He, Weijiang Zheng, Chengyuan Tao

et al.

Environmental Pollution, Journal Year: 2020, Volume and Issue: 266, P. 115111 - 115111

Published: June 29, 2020

Language: Английский

Citations

38