New perspectives on PPAR, VDR and FXRα as new actors in testicular pathophysiology DOI

M. Monrose,

Laura Thirouard, Pérez García

et al.

Molecular Aspects of Medicine, Journal Year: 2020, Volume and Issue: 78, P. 100886 - 100886

Published: Aug. 30, 2020

Language: Английский

Zingerone modulates the circulating steroids hormone levels and testicular steroidogenic markers expression in mice: An in vivo and in silico study DOI

Miti Jerang,

Guruswami Gurusubramanian, Ved Prakash Singh

et al.

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 106748 - 106748

Published: April 1, 2025

Language: Английский

Citations

0
Vitamin D alleviates chronic stress-induced testicular steroidogenesis disruption in Wistar rats DOI
Siddhi Srivastava,

Sukriti Srivastava,

Vipul Agarwal

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102910 - 102910

Published: April 1, 2025

Language: Английский

Citations

0
Portulaca oleracea seeds’ extract alleviates acrylamide-induced testicular dysfunction by promoting oxidative status and steroidogenic pathway in rats DOI Creative Commons

Ola M. Farag,

Reham M. Abd‐Elsalam, Shymaa A. El Badawy

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2021, Volume and Issue: 21(1)

Published: April 14, 2021

Acrylamide (ACR) is a widespread industrial and food contaminant that garnered considerable attention for its carcinogenic, neurotoxic, reproductive toxic effects. The antioxidant effects of Portulaca oleracea seeds extract (POS) fertility-enhancing were inspiring to evaluate the protective potential pinpoint mechanisms molecular targets UPLC-MS fingerprinted POS on ACR-induced testicular toxicity in rats.Male Wistar rats divided into 6 equal groups negative control, ACR model (10 mg/kg b.wt.), at doses (200 400 b.wt.) POS-treated groups. All treatments given by oral dosing every day 60 days.Administration reversed epididymides weight loss with improved semen quality count, ameliorated ACR-decreased lesion scoring, oxidative stress, degeneration, Leydig cell apoptosis dysregulated PCNA Caspase-3 expression dose-dependent manner. It upregulated declined level serum testosterone steroidogenic genes such as CYP11A1 17β3-HSD an obvious histologic improvement testes re-establishment normal spermatogenic series, Sertoli cells.The supplementation may provide effect dysfunction which mediated antioxidant, antiapoptotic modulatory

Language: Английский

Citations

26
Effects of melatonin on a d-galactose-induced male reproductive aging mouse model DOI

Won-Young Lee,

Heyon Woo Sim,

Hyun-Jung Park

et al.

Theriogenology, Journal Year: 2023, Volume and Issue: 206, P. 181 - 188

Published: May 4, 2023

Language: Английский

Citations

9
Cell-type specific and differential expression of LINC-RSAS long noncoding RNA declines in the testes during ageing of the rat DOI
Ajay Kumar Danga, Sukhleen Kour, A. Leela Kumari

et al.

Biogerontology, Journal Year: 2024, Volume and Issue: 25(3), P. 543 - 566

Published: Feb. 14, 2024

Language: Английский

Citations

3
Male and female gonadal ageing: its impact on health span and life span DOI
Mónica Beatriz Frungieri,

Ricardo S. Calandra,

Andrzej Bartke

et al.

Mechanisms of Ageing and Development, Journal Year: 2021, Volume and Issue: 197, P. 111519 - 111519

Published: June 15, 2021

Language: Английский

Citations

21
Effect of vitamin D on cardiac hypertrophy in D-galactose-induced aging model through cardiac mitophagy DOI
‬Siamak Shahidi,

Khadijeh Ramezani-Aliakbari,

Alireza Komaki‬

et al.

Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(12), P. 10147 - 10155

Published: Nov. 3, 2023

Language: Английский

Citations

8
Alginate oligosaccharide alleviates senile osteoporosis via the RANKL–RANK pathway in D‐galactose‐induced C57BL/6J mice DOI Creative Commons
Shan Wang, Wenjing Feng,

Jianya Liu

et al.

Chemical Biology & Drug Design, Journal Year: 2021, Volume and Issue: 99(1), P. 46 - 55

Published: June 19, 2021

Osteoporosis is a systemic skeletal disorder characterized by reduced bone mineral density (BMD) and quality increased porosity, which increase the risk of fracture. Inflammation, one important mechanisms related to aging, associated with osteoporosis. Treatment anti-inflammatory agents effective for alleviating senile Alginate oligosaccharide (AOS) can prevent treat diseases inflammation, oxidative stress, immunity. This study evaluates effect AOS on osteoporosis investigates underlying mechanism. model was induced D-galactose (D-gal) (200 mg kg-1 day-1 ) eight weeks. Three groups were administered via (50, 100, 150 four weeks, while control group received sterile water (5 ml 8 The results showed that improved microstructure in D-gal-induced mice. inhibited osteoclast proliferation, probably through suppression receptor activator nuclear factor-kappa B ligand (RANKL)-associated factor kappa (NF-κB) c-Fos signaling pathway. also osteoprotegerin (OPG) expression competitively binding between RANK RANKL Further, decreased secretion serum osteocalcin conversion. Together, these demonstrate anti-osteoporosis activity mice

Language: Английский

Citations

19
Possible role of apelin on the ovarian steroidogenesis and uterine apoptosis of infantile mice: An in vitro study DOI

Borgohain Anima,

Guruswami Gurusubramanian, Vikas Kumar Roy

et al.

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2024, Volume and Issue: 238, P. 106463 - 106463

Published: Jan. 21, 2024

Language: Английский

Citations

2
Effect of vitamin D on oxidative stress indices and ram semen parameters DOI

Y. Teymoori,

Mehrdad Mohri, Pezhman Mirshokraei

et al.

Small Ruminant Research, Journal Year: 2024, Volume and Issue: 232, P. 107207 - 107207

Published: Jan. 28, 2024

Language: Английский

Citations

2