Traditional uses of Cannabis: An analysis of the CANNUSE database DOI Creative Commons
Manica Balant, Airy Gras, Mario Humberto Ruz Sosa

et al.

Journal of Ethnopharmacology, Journal Year: 2021, Volume and Issue: 279, P. 114362 - 114362

Published: June 24, 2021

Cannabis is one of the most versatile genera in terms plant use and has been exploited by humans for millennia. Nowadays, centre many scientific studies, them focusing on chemical composition medicinal values. While new varied applications are continuously being developed, knowledge surrounding less common uses slowly disappearing. We have analysed diversity global data traditional uses, to investigate if certain parts significantly associated with particular use. wanted uncover potential associations between used treatment different body systems ailments. extensive database (CANNUSE). This contains 2330 entries ethnobotanical from over 40 countries across world. The dataset was divided into five general groups based type use: medicinal, alimentary, psychoactive, fibre other uses. Given abundance human detailed analysis done subset 1167 entries. relationship 16 system categories ailments treated parts. a Pearson's chi-square Fisher's exact test, determine which characteristic specific In this dataset, majority reports were represented (75.41%), followed psychoactive (8.35%) alimentary (7.29%) commonly leaf (50.51%), seed (15.38%) inflorescence (11.35%). found that uses; typically Regarding treatments digestive nutritional disorders (17.66%), nervous mental (16.24%), pain inflammations (12.21%). significant categories; two categories: skin subcutaneous tissue circulatory blood disorders; musculoskeletal traumas; while shows statistical support disorders. Several pharmaceutical companies intensely working developing drugs isolated compounds or crude extracts, almost exclusively inflorescences. However, our review revealed medicine often more important than A provides an initial pathway identify landraces could role future research. confident still large modern medicine. As information (genetics, biochemistry, clinical studies) becomes available, poised be much greater significance.

Language: Английский

Evolution, genetics and biochemistry of plant cannabinoid synthesis: a challenge for biotechnology in the years ahead DOI Creative Commons
Rainer Melzer, Paul F. McCabe, Susanne Schilling

et al.

Current Opinion in Biotechnology, Journal Year: 2022, Volume and Issue: 75, P. 102684 - 102684

Published: Jan. 24, 2022

Cannabis sativa is most prominent for its psychoactive secondary compound tetrahydrocannabinol, or THC. However, THC only one of many phytocannabinoids found in this (in)famous medicinal plant. The stepwise legalization countries has opened opportunities and commercial use, sparking scientific interest the genetics biochemistry phytocannabinoid synthesis. Advances plant biology genomics help to accelerate research field, which still lagging behind other comparable high-value crops. Here, we discuss intriguing evolutionary history synthases, also show that an increased understanding developmental morphology are critical importance leverage full potential production.

Language: Английский

Citations

70
The Medicinal Natural Products of Cannabis sativa Linn.: A Review DOI Creative Commons
Anwuli Endurance Odieka,

Gloria Ukalina Obuzor,

Opeoluwa O. Oyedeji

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(5), P. 1689 - 1689

Published: March 4, 2022

is known among many cultures for its medicinal potential. Its complexity contributes to the historical application of various parts plant in ethno-medicines and pharmacotherapy.

Language: Английский

Citations

67
Cannabinoids and Terpenes: How Production of Photo-Protectants Can Be Manipulated to Enhance Cannabis sativa L. Phytochemistry DOI Creative Commons
Vincent Desaulniers Brousseau, Bo-Sen Wu, Sarah MacPherson

et al.

Frontiers in Plant Science, Journal Year: 2021, Volume and Issue: 12

Published: May 31, 2021

Cannabis sativa L. is cultivated for its secondary metabolites, of which the cannabinoids have documented health benefits and growing pharmaceutical potential. Recent legal cannabis production in North America Europe has been accompanied by an increase reported findings optimization naturally occurring synthetic cannabinoid production. Of many environmental cues that can be manipulated during plant growth controlled environments, cultivation with different lighting spectra indicates differential accumulation medically important cannabinoids, including Δ 9 -tetrahydrocannabinol (Δ -THC), cannabidiol (CBD), cannabigerol (CBG), as well terpenes flavonoids. Ultraviolet (UV) radiation shows potential stimulating biosynthesis trichomes pre-harvest or post-harvest UV treatment merits further exploration to determine if metabolite could enhanced this manner. Visible LED light augment THC terpene accumulation, but not CBD. Well-designed experiments wavelengths other than blue red will provide more insight into light-dependent regulatory molecular pathways cannabis. Lighting strategies such subcanopy varied at developmental stages lower energy consumption optimize PSM Although evidence demonstrates metabolites may modulated spectrum like species, several questions remain fast-paced industry. In summarizing recent research progress on cannabis, along pertinent responses model future directions are presented.

Language: Английский

Citations

65
Chemical composition and antioxidant potential of Cannabis sativa L. roots DOI Creative Commons

Christoph Kornpointner,

Aitor Sainz Martinez,

Silvija Marinovic

et al.

Industrial Crops and Products, Journal Year: 2021, Volume and Issue: 165, P. 113422 - 113422

Published: March 18, 2021

Cannabis sativa L. has long been exploited for multiple purposes. Whereas all parts of the shoots are extensively used and well investigated, roots have always received less attention. The phytochemical spectrum differs significantly from rest plant, as no significant amounts cannabinoids found, whereas triterpenes phytosterols abundantly present. To shed light on unique phytochemistry hemp related industrial potential, three chemovars were investigated secondary metabolite composition antioxidant activities by using in vitro vivo methods. Five triterpenes, ten five aliphatic compounds identified GC–MS analysis. Glutinol, ß-amyrone, stigmastanol, fucosterol, stigmasta-3,5-diene, stigmasta-3,5,22-triene, oleamide described first time cannabis root extracts. predominant triterpenoids friedelin (0.100−0.709 mg/g) epifriedelinol (0.059−0.205 quantified dependence chemovar, harvest times, drying conditions, extraction efficiency with ethanol, n-hexane, supercritical CO2.

Language: Английский

Citations

64
Positive Effect of Cannabis sativa L. Herb Extracts on Skin Cells and Assessment of Cannabinoid-Based Hydrogels Properties DOI Creative Commons
Martyna Zagórska-Dziok, Tomasz Bujak, Aleksandra Ziemlewska

et al.

Molecules, Journal Year: 2021, Volume and Issue: 26(4), P. 802 - 802

Published: Feb. 4, 2021

The skin is an organ that constantly exposed to many external factors can affect its structure and function. Due the presence of different cannabinoid receptors on types cells, cannabinoids interact directly with them. Therefore, as part this work, impact two Cannabis sativa L. herb extracts keratinocytes fibroblasts was assessed. content biologically active compounds such phenols, flavonoids, chlorophylls evaluated. antioxidant capacity prepared using DPPH radical, H2DCFDA probe measurement superoxide dismutase activity also cytotoxicity hemp determined Alamar Blue, Neutral Red LDH assays. ability inhibit matrix metalloproteinases, collagenase elastase, Preparations model hydrogels were their effect transepidermal water loss hydration measured. obtained results indicate be a valuable source substances reduce oxidative stress, aging processes positively viability cells. analysis showed based cannabis have positive hydration.

Language: Английский

Citations

57
Analytical Techniques for Phytocannabinoid Profiling of Cannabis and Cannabis-Based Products—A Comprehensive Review DOI Creative Commons
Gjoshe Stefkov, Ivana Cvetkovikj Karanfilova, Veronika Stoilkovska Gjorgievska

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(3), P. 975 - 975

Published: Feb. 1, 2022

Cannabis is gaining increasing attention due to the high pharmacological potential and updated legislation authorizing multiple uses. The development of time- cost-efficient analytical methods crucial importance for phytocannabinoid profiling. This review aims capture versatility profiling cannabis cannabis-based products in past four decades (1980-2021). thorough overview more than 220 scientific papers reporting different techniques points out their respective advantages drawbacks terms complexity, duration, selectivity, sensitivity robustness specific application, along with most widely used sample preparation strategies. In particular, chromatographic spectroscopic methods, are presented discussed. Acquired knowledge profile became extremely relevant further enhanced chemotaxonomic classification, cultivation set-ups examination, association medical adverse health effects potency and/or interplay certain phytocannabinoids other active constituents, quality control (QC), stability studies, as well harmonization global standards. Further improvement should be focused on untargeted analysis using orthogonal which, joined cheminformatics approaches compound identification MSLs, would lead a multitude new phytocannabinoids.

Language: Английский

Citations

44
Nitrogen deficiency stimulates cannabinoid biosynthesis in medical cannabis plants by inducing a metabolic shift towards production of low-N metabolites DOI
Chao Song,

Avia Saloner,

Aaron Fait

et al.

Industrial Crops and Products, Journal Year: 2023, Volume and Issue: 202, P. 116969 - 116969

Published: June 21, 2023

Language: Английский

Citations

25
Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis DOI Creative Commons
Ziyan Xie,

Yaolei Mi,

Lingzhe Kong

et al.

Horticulture Research, Journal Year: 2023, Volume and Issue: 10(9)

Published: July 26, 2023

Is Cannabis a boon or bane? sativa has long been versatile crop for fiber extraction (industrial hemp), traditional Chinese medicine (hemp seeds), and recreational drugs (marijuana). faced global prohibition in the twentieth century because of psychoactive properties ∆9-tetrahydrocannabinol; however, recently, perspective changed with recognition additional therapeutic values, particularly pharmacological potential cannabidiol. A comprehensive understanding underlying mechanism cannabinoid biosynthesis is necessary to cultivate promote globally medicinal application resources. Here, we comprehensively review historical usage Cannabis, trichome-specific cannabinoids, regulatory network trichome development, synthetic biology cannabinoids. This provides valuable insights into efficient green production development utilization novel varieties.

Language: Английский

Citations

25
Partially substituting alfalfa hay with hemp forage in the diet of goats improved feed efficiency, ruminal fermentation pattern and microbial profiles DOI Creative Commons
Ran Tao, Zhipeng Xu, Wenzhu Yang

et al.

Animal nutrition, Journal Year: 2024, Volume and Issue: 17, P. 49 - 60

Published: Jan. 29, 2024

The use of hemp as a forage source in livestock diets has been less studied because bioactive residues animal tissues may pose risk to consumers. This study investigated the effects partial substitution alfalfa hay (AH) with (HF) growing goat on growth performance, carcass traits, ruminal fermentation characteristics, rumen microbial communities, blood biochemistry, and antioxidant indices. Forty Xiangdong black goats body weight (BW) 7.82 ± 0.57 kg (mean SD) were grouped by BW randomly assigned into one four treatment (

Language: Английский

Citations

11
Influence of different priming treatments on germination potential and seedling establishment of four important hemp (Cannabis sativa L.) cultivars DOI Creative Commons

Saba Latif,

Rahmatullah Qureshi, Abdul Rauf

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 24, 2025

Language: Английский

Citations

1