A systematic review and meta‐analysis of long‐term sequelae of COVID‐19 2‐year after SARS‐CoV‐2 infection: A call to action for neurological, physical, and psychological sciences

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(6)

Published: June 1, 2023

Abstract Long‐term sequelae conditions of COVID‐19 at least 2‐year following SARS‐CoV‐2 infection are unclear and little is known about their prevalence, longitudinal trajectory, potential risk factors. Therefore, we conducted a comprehensive meta‐analysis survivors' health‐related consequences infection. PubMed/MEDLINE, CENTRAL, EMBASE were systematically searched up to February 10, 2023. A systematic review performed calculate the pooled effect size, expressed as event rate (ER) with corresponding 95% confidence interval (CI) each outcome. Twelve studies involving 1 289 044 participants from 11 countries included. total 41.7% survivors experienced one unresolved symptom 14.1% unable return work after The most frequent symptoms investigated findings fatigue (27.4%; CI 17%–40.9%), sleep difficulties (25.1%; 22.4%–27.9%), impaired diffusion capacity for carbon monoxide (24.6%; 10.8%–46.9%), hair loss (10.2%; 7.3%–14.2%), dyspnea (10.1%; 4.3%–21.9%). Individuals severe suffered more anxiety (OR = 1.69, 1.17–2.44) had impairments in forced vital 9.70, 1.94–48.41), lung 3.51, 1.77–6.99), residual volume 3.35, 1.85–6.07) recovery. Existing evidence suggest that higher long‐term older, mostly female, pre‐existing medical comorbidities, status, underwent corticosteroid therapy, inflammation acute Our recovery infection, still suffer either neurological, physical, psychological sequela. These indicate there an urgent need preclude persistent or emerging provide intervention strategies reduce long COVID.

Language: Английский

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Alcohol induces long-lasting sleep deficits in Drosophila via subsets of cholinergic neurons

Current Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Sleep and liver disease: a bidirectional relationship

˜The œLancet. Gastroenterology & hepatology, Journal Year: 2021, Volume and Issue: 6(10), P. 850 - 863

Published: July 15, 2021

Language: Английский

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Alcohol and aging – An area of increasing concern

Alcohol, Journal Year: 2022, Volume and Issue: 107, P. 19 - 27

Published: Aug. 5, 2022

Language: Английский

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Harmonization of alcohol use data and mortality across a multi‐national HIV cohort collaboration

Alcohol Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 49(2), P. 407 - 417

Published: Jan. 8, 2025

Alcohol use is measured in diverse ways across settings. Harmonization of measures necessary to assess effects alcohol multi-cohort collaborations, such as studies people with HIV (PWH). Data were combined from 14 cohort (nine European, five North American) participating the Antiretroviral Therapy Cohort Collaboration. We analyzed data on adult PWH at any time 6 months before starting antiretroviral therapy. Five cohorts AUDIT-C and others used cohort-specific measures. harmonized grams/day, calculated using country-level definitions a standard drink. For Use Disorders Identification Test (AUDIT-C), we Items 1 (frequency) 2 (number drinks typical day). Where was categories, mid-point calculate grams/day. multivariable Cox models estimate associations mortality. available for 83,424 PWH, 22,447 (27%) had 60,977 (73%) recorded number drinks/units per week/day. Of sample, 19,150 (23%) female, 54,006 (65%) White ethnicity, median age 42 years. Median 0.3 g/day (interquartile range [IQR] 0-4.8) 0 (IQR 0-20) those without AUDIT-C. There J-shaped relationship between grams/day mortality, higher mortality reporting no (adjusted hazard ratio [aHR] 1.46; 95% CI: 1.23-1.72) heavier (>61.0 g/day) (aHR 1.92; 1.41-2.59) compared 0.1-5.5 among Associations similar non-AUDIT-C Grams/day useful metric harmonize use. Magnitudes may differ by setting measurement method. Higher strengthens case interventions reduce drinking.

Language: Английский

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Association between alcohol consumption and sleep traits: observational and mendelian randomization studies in the UK biobank

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(3), P. 838 - 846

Published: Jan. 18, 2024

Language: Английский

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Association between dietary habits and the risk of migraine: a Mendelian randomization study

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: June 7, 2023

The important contribution of dietary triggers to migraine pathogenesis has been recognized. However, the potential causal roles many habits on risk in whole population are still under debate. objective this study was determine association between and (and its subtypes) development, as well possible mediator factors.Based summary statistics from large-scale genome-wide studies, we conducted two-sample Mendelian randomization (MR) bidirectional MR investigate associations 83 subtypes, network performed explore 8 factors.After correcting for multiple testing, found evidence genetically predicted coffee, cheese, oily fish, alcohol (red wine), raw vegetables, muesli, wholemeal/wholegrain bread intake with decreased migraine, those odds ratios ranged 0.78 (95% CI: 0.63-0.95) overall cheese 0.61 0.47-0.80) drinks usually meals among current drinkers (yes + it varies vs. no); while white bread, cornflakes/frosties, poultry were positively associated migraine. Additionally, genetic liability fish a higher insomnia (or) major depression disorder (MDD), each them may act pathway several Finally, negative drinking types, positive cups tea per day.Our provides about demonstrates that some partly mediated through one or both MDD. These results provide new insights further nutritional interventions prevention.

Language: Английский

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A systematic review of self-report measures used in epidemiological studies to assess alcohol consumption among older adults

PLoS ONE, Journal Year: 2021, Volume and Issue: 16(12), P. e0261292 - e0261292

Published: Dec. 16, 2021

Background There is a lack of standardization regarding how to assess and categorize alcohol intake in older adults. The aim this study was systematically review methods used epidemiological studies define drinking patterns measure consumption among Methods A systematic search conducted the MEDLINE, PubMed, PsycINFO, EMBASE, CINAHL databases for published from January 2009 April 2021. Studies were included if they observational with quantitative design; mean age participants ≥ 65 years; questionnaires, screening tools, or diagnostic tools consumption; self-reported. Results Of 492 considered, 105 included. Among studies, we detected 19 different patterns, each pattern had wide range definitions. abstaining alcohol, current drinking, risk seven, 12 21 diverse definitions, respectively. most questionnaire quantity-frequency questionnaire, recall period months, full short versions Alcohol Use Disorders Identification Test, Conclusion No consensus found assess, define, Identical assessments definitions must be developed make valid comparisons We recommend that surveys adults following patterns: lifetime abstainers, former drinkers, heavy episodic drinking. Standardized should developed. expanded including three questions focused on frequency, volume, could used.

Language: Английский

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Association between early life second-hand smoke exposure on child sleep and psychoactive substance use on adult sleep patterns in an urban informal settlement in Uganda

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0312127 - e0312127

Published: Jan. 3, 2025

Background Psychoactive substance use in adults and second-hand smoke (SHS) exposure among children are leading contributors to sleeping problems. Despite this, there is limited data on how these exposures influence sleep patterns informal settings. Our study assessed the associations between use, SHS disturbances an urban settlement Uganda. Methods We conducted a cross-sectional Kampala, Data was collected self-reported problems including duration, insomnia dissatisfaction, as well, sleep-disordered breathing (SDB) children. evaluated children’s early-life psychoactive using questionnaires. modelled modified Poisson regression. Results were from 284 adults, who also reported their experience. Among 59.2% insufficient (less than 7 hours), 34.9% experienced insomnia, 28.3% dissatisfied with patterns. Active smoking associated (Prevalence Ratio (PR) = 2.74, 95% Confidence Interval (CI): 1.14–6.59), alcohol dissatisfaction (PR 1.81, CI 1.23–2.69). In children, 40.0% (88/220) exhibited SDB Those exposed either during pregnancy or within six months post-birth had higher risk of unexposed 1.78, 1.21–2.61). The elevated for both periods 1.48, 1.02–2.13). Conclusions findings suggest that adults. Early-life increased These results emphasize need support ongoing public health initiatives maintain smoke-free environment, particularly early life.

Language: Английский

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Factores sociodemográficos asociados a los patrones de consumo de alcohol de los trabajadores de industrias maquiladoras

Horizon Interdisciplinary Journal, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 3, 2025

Introducción: El consumo de alcohol, se considera un problema salud pública por su gran carga social y económica para la población en general. Además ser el causante una serie consecuencias sanitarias sociales. Entre 3% 5% que trabaja son dependientes al siendo 25% consumidores riesgosos. Existen cifras indican altas incidencias accidentes letales donde 20% los trabajadores estaban estado intoxicación; nivel ausentismo trabajo es 2 a 3 veces más alto demás empleados. Objetivo: Conocer asociación patrones alcohol con factores sociodemográficos industrias maquiladoras. Metodología: diseño del estudio fue descriptivo, correlacional corte transversal, participaron maquiladoras ciudad Nuevo Laredo; Tamaulipas. La muestra 184. Se empleó muestreo no probabilístico conveniencia. Los instrumentos medición fueron cédula datos personales prevalencia además cuestionario identificación trastornos debidos (AUDIT). investigación fundamentó lo dispuesto Reglamento Ley General Salud Materia Investigación Salud. Para análisis, utilizó paquete estadístico las ciencias sociales (IBM-SPSS) versión 26 Windows 10. Resultados: 91.3% han probado alguna vez vida consumieron últimos 12 meses. 68.5% consumió 30 días 44.6% siete días. tipo prevaleció riesgoso 46.4%, seguido dependiente 36.3% y, hasta 17.3% forma perjudicial. Además, encontró mayor proporción hombres. Las mujeres reportaron dependiente; hombres Por último, existe relación negativa significativa entre edad (rs=-0.340, p<.001) positiva años antigüedad (rs=0.162, p<0.050) cantidad (rs=-0.542, p<.001). Conclusiones: consumen cuentan menor edad, tienen laboral bebidas estándar.

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