Experimental, molecular docking and molecular dynamic studies of natural products targeting overexpressed receptors in breast cancer DOI Creative Commons
Mohammad Sadegh Taghizadeh, Ali Niazi‎, Ali Moghadam

et al.

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(5), P. e0267961 - e0267961

Published: May 10, 2022

Natural compounds are proper tools for inhibiting cancer cell proliferation. Hence, the search these ligands of overexpressed receptors in breast has been a competitive challenge recently and opens new avenues drug discovery. In this research, we have investigated molecular interactions between natural products using docking dynamic simulation approaches followed by extraction best ligand from Citrus limetta developing nanoscale encapsulation composed soy lecithin sonicator machine. The process was confirmed DLS TEM analyses. Anticancer activity also examined MTT method. Among compounds, hesperidin found to bind specific targets with stronger binding energy. dynamics results indicated that hesperidin-MCL-1 complex is very stable at 310.15 K 200 ns. RP-HPLC analysis revealed purity extracted 98.8% yield 1.72%. showed strong interaction an entrapped efficiency 92.02 ± 1.08%. Finally, cytotoxicity effect increased against MDA-MB-231 line IC50 value 62.93 μg/mL after encapsulation, whereas no significant MCF10A line. We first time flexible MCL-1 receptor. Also, it vitro ability kill lines without having on lines. Therefore, could be used as food ingredient generate functional foods.

Language: Английский

Enhanced In Vivo Radiotherapy of Breast Cancer Using Gadolinium Oxide and Gold Hybrid Nanoparticles DOI Creative Commons

Hamed Nosrati,

Marziyeh Salehiabar,

Jalil Charmi

et al.

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(2), P. 784 - 792

Published: Jan. 24, 2023

Radiation therapy has demonstrated promising effectiveness against several types of cancers. X-ray radiation can be made further effective by utilizing nanoparticles high-atomic-number (high-Z) materials that act as radiosensitizers. Here, in purpose maximizing the within tumors, bovine serum albumin capped gadolinium oxide and gold (Gd2O3@BSA-Au NPs) are developed a bimetallic radiosensitizer. In this study, we incorporate two high-Z-based nanoparticles, Au Gd, single nanoplatform. The radiosensitizing ability was assessed with series vitro tests, following evaluation vivo breast cancer murine model. Enhanced tumor suppression is observed group received after administration Gd2O3@BSA-Au NPs. As result, efficacy significantly improved applying NPs under irradiation, evidenced studies evaluating cell viability, proliferation, reactive oxygen species production, anti-tumor effect.

Language: Английский

Citations

50
Chronic inflammation and cancer; the two sides of a coin DOI
Queenie Fernandes,

Varghese Inchakalody,

Takwa Bedhiafi

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 338, P. 122390 - 122390

Published: Dec. 30, 2023

Language: Английский

Citations

46
Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress DOI
Mustafa İleritürk, Özge Kandemir, Nurhan Akaras

et al.

Reproductive Toxicology, Journal Year: 2023, Volume and Issue: 118, P. 108369 - 108369

Published: March 24, 2023

Language: Английский

Citations

44
Optimized Hesperidin-Loaded Lipid Nanoparticles with Tea Tree Oil for Enhanced Wound Healing: Formulation, Characterization, and Evaluation DOI Creative Commons
Borros Arneth, Rehab Abdelmonem, Mohamed A. El-Nabarawi

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 290 - 290

Published: Feb. 20, 2025

Objectives: This study aimed to develop hesperidin solid lipid nanoparticles (HESP-SLNs) enhance their stability, solubility, and sustained release for wound healing; further enhancement was achieved through prepared nanostructured carriers (HESP-NLCs) using Tea Tree Oil (TTO) explore synergistic efficacy. Methods: A factorial design of 24 trials established evaluate the influence type (X1), conc (%) (X2), surfactant (X3), sonication amplitude (X4) HESP-SLNs on particle size (nm) (Y1), polydispersibility index (Y2), zeta potential (Y3), encapsulation efficiency (Y4). The optimized formula selected utilizing Design Expert® software version 13, which additionally enhanced by preparing TTO-loaded HESP-NLCs. In vitro release, Raman spectroscopy, transmission electron microscopy were carried out both nanoparticles. Cytotoxicity, in vivo wound-healing assessments, skin irritancy tests performed performance TTO-incorporated HESP-NLCs compared HESP-SLNs. Results: demonstrated PS (280 ± 1.35 nm), ZP (−39.4 0.92 mV), PDI (0.239 0.012), EE% (88.2 2.09%). NLCs Q6% (95.14%) vs. (79.69%), SLNs showed superior antimicrobial Both exhibited spherical morphology compatibility between HESP excipients. highest closure percentage, supported histological analysis inflammatory biomarker outcomes. Cytotoxicity evaluation 87% cell viability untreated HSF cells, test confirmed safety NLCs. Conclusions: are promising candidates exhibiting capabilities, making them a therapeutic option cutaneous management.

Language: Английский

Citations

2
Green synthesis of silver nanoparticles from Eriobotrya japonica extract: a promising approach against cancer cells proliferation, inflammation, allergic disorders and phagocytosis induction DOI Creative Commons
Majid S. Jabir,

Aya Ali Hussien,

Ghassan M. Sulaiman

et al.

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2021, Volume and Issue: 49(1), P. 48 - 60

Published: Jan. 1, 2021

Nanoparticles (NPs) have biological activities like antibacterial, antifungal, drug delivery, immunomodulation and antitumor activities. The aim of the current study was to investigate some biomedical applications silver NP synthesis using extracts from leaves Eriobotrya japonica. Colour changes, UV-visible spectroscopy, SEM, zeta potential, dynamic light scattering, FTIR XRD were used confirm AgNPs formation. UV-vis spectrum absorption band observed at almost 430 nm. SEM image shows quasi-spherical shape AgNPs. potential demonstrated negative surface charge NPs. results showed functional groups Crystalline nature confirmed by pattern. MTT assay anti-proliferative activity against MCF-7 HeLa cells. Apoptosis tested a DNA-fragmentation test, expression P53. inhibited proliferation cells, reduced inflammation. Treatment with significantly decreased allergic disorder. stimulated phagocytosis process in BMDMs. suggested that could be promising therapy for future preventing inflammation, reduce disorders prevent bacterial infection through up-regulation phagocytosis. Hence, work such as developed improved NPs adjuvants, immune-modulating substances nano-drug delivery system is needed.

Language: Английский

Citations

95
Ougan juice debittering using ultrasound-aided enzymatic hydrolysis: Impacts on aroma and taste DOI
Xianli Gao,

Tuo Feng,

Ermeng Liu

et al.

Food Chemistry, Journal Year: 2020, Volume and Issue: 345, P. 128767 - 128767

Published: Dec. 3, 2020

Language: Английский

Citations

93
Food additives containing nanoparticles induce gastrotoxicity, hepatotoxicity and alterations in animal behavior: The unknown role of oxidative stress DOI
Estefany I. Medina‐Reyes, Carolina Rodríguez‐Ibarra, Alejandro Déciga‐Alcaraz

et al.

Food and Chemical Toxicology, Journal Year: 2020, Volume and Issue: 146, P. 111814 - 111814

Published: Oct. 15, 2020

Language: Английский

Citations

91
Fe3O4 Nanoparticles Capped with PEG Induce Apoptosis in Breast Cancer AMJ13 Cells Via Mitochondrial Damage and Reduction of NF-κB Translocation DOI
Majid S. Jabir, Uday M. Nayef,

Waleed K. Abdulkadhim

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2020, Volume and Issue: 31(3), P. 1241 - 1259

Published: Oct. 24, 2020

Language: Английский

Citations

80
<p>Linalool-Loaded Glutathione-Modified Gold Nanoparticles Conjugated with CALNN Peptide as Apoptosis Inducer and NF-κB Translocation Inhibitor in SKOV-3 Cell Line</p> DOI Creative Commons
Majid S. Jabir,

Usama I. Sahib,

Zainab J. Taqi

et al.

International Journal of Nanomedicine, Journal Year: 2020, Volume and Issue: Volume 15, P. 9025 - 9047

Published: Nov. 1, 2020

Linalool is a monoterpene compound with various potential therapeutic applications in several medical fields. Previous studies have indicated the activity of linalool against cell lines; however, its high level toxicity restricts use. The aim this study was to design and manufacture compounds novel structure that can be used for loading linalool, reduce improve reachable ability.We synthesized characterized new molecule onto gold nanoparticles (GNPs) capped glutathione conjugated CALNN peptide. loaded GNPs via reaction surface groups both GNPs. Moreover, target peptide could chemical reaction. cytotoxic effects linalool-GNP (LG) linalool-GNP-CALNN (LGC) conjugates ovarian cancer cells were investigated, as possible mechanisms underlying induction apoptosis.Our findings illustrated significant antiproliferative effect LG LGC on SKOV-3 cells. cytotoxicity assay demonstrated selectively toxic induced apoptosis by activating caspase-8, p53 protein, proteins involved apoptosis. present data should given particular consideration anticancer drug-delivery systems, remarkably more line than alone.We concluded are promising treating (SKOV-3) through extrinsic intrinsic pathways.

Language: Английский

Citations

78
Biocompatibility of gold nanoparticles: In-vitro and In-vivo study DOI

Rua J. Kadhim,

Esraa H. Karsh,

Zainab J. Taqi

et al.

Materials Today Proceedings, Journal Year: 2021, Volume and Issue: 42, P. 3041 - 3045

Published: Jan. 1, 2021

Language: Английский

Citations

76