Silver Nanoparticles: Bactericidal and Mechanistic Approach against Drug Resistant Pathogens

Microorganisms, Journal Year: 2023, Volume and Issue: 11(2), P. 369 - 369

Published: Feb. 1, 2023

This review highlights the different modes of synthesizing silver nanoparticles (AgNPs) from their elemental state to particle format and mechanism action against multidrug-resistant biofilm-forming bacterial pathogens. Various studies have demonstrated that AgNPs cause oxidative stress, protein dysfunction, membrane disruption, DNA damage in bacteria, ultimately leading death. also been found alter adhesion cells prevent biofilm formation. The benefits using medicine are, some extent, counter-weighted by toxic effect on humans environment. In this review, we compiled recent demonstrating antibacterial activity AgNPs, are discussing known mechanisms Ongoing clinical trials involving briefly presented. A particular focus is placed interaction with biofilms, which a significant pathogenicity determinant. brief overview use other medical applications (e.g., diagnostics, promotion wound healing) non-medical sectors Finally, current drawbacks limitations discussed, perspectives for improved future functionalized

Language: Английский

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Green Synthesis and Potential Antibacterial Applications of Bioactive Silver Nanoparticles: A Review

Polymers, Journal Year: 2022, Volume and Issue: 14(4), P. 742 - 742

Published: Feb. 15, 2022

Green synthesis of silver nanoparticles (AgNPs) using biological resources is the most facile, economical, rapid, and environmentally friendly method that mitigates drawbacks chemical physical methods. Various such as plants their different parts, bacteria, fungi, algae, etc. could be utilized for green bioactive AgNPs. In recent years, several approaches non-toxic, facile AgNPs have been reported. Plant extract contains various biomolecules, including flavonoids, terpenoids, alkaloids, phenolic compounds, vitamins act reducing capping agents during biosynthesis process. Similarly, microorganisms produce primary secondary metabolites play a crucial role synthesis. Biosynthesized gained significant attention from researchers because potential applications in fields biomedical science. The widest application bactericidal activity. Due to emergence multidrug-resistant microorganisms, are exploring therapeutic abilities antibacterial agents. Already, reports suggested biosynthesized exhibited action against numerous human pathogens. Because small size large surface area, ability easily penetrate bacterial cell walls, damage membranes, reactive oxygen species, interfere with DNA replication well protein synthesis, result death. This paper provides an overview green, rapid use AgNPs, highlighting mechanisms.

Language: Английский

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Effect of Kaolin clay and Ficus carica mediated silver nanoparticles on chitosan food packaging film for fresh apple slice preservation

Food Chemistry, Journal Year: 2023, Volume and Issue: 410, P. 135470 - 135470

Published: Jan. 11, 2023

Language: Английский

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Green Synthesis of Silver Nanoparticles from Root Extracts of Rubus ellipticus Sm. and Comparison of Antioxidant and Antibacterial Activity

Journal of Nanomaterials, Journal Year: 2022, Volume and Issue: 2022(1)

Published: Jan. 1, 2022

The fabrication of metal nanoparticles through green synthetic pathways using plant extracts has increased attention due to low cost, benevolent methods, fewer hazardous byproducts, and applications. Silver (AgNPs) were synthesized by reacting aqueous root Rubus ellipticus Sm. (RERE) with AgNO 3 solution (1 mM) at an ambient condition. visual change color from light yellow reddish brown the absorption peak 416‐420 nm in UV‐visible spectra indicated formation AgNPs solution. shifting positions FTIR potential role functional groups as capping stabilizing agents. powder XRD diffractogram exposed crystalline nature nanoparticles. surface morphology elemental composition established FESEM EDX analysis. TEM images revealed spherical monodispersed size ranging 13.85 34.30 average 25.20 ± 7.01 ( n = 10). biogenic showed a better 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activity lower IC 50 (13.83 0.33 μ g/mL) compared that RERE (15.86 4.14 g/mL). higher zones inhibition (ZOI) on agar well diffusion method against Enterococcus faecalis (ATCC 29212), Escherichia coli 25922), Staphylococcus aureus 25923), Klebsiella pneumoniae 700603). result this study highlights benefits R. extract‐based for biomedical practices.

Language: Английский

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Antibiofilm activity of green synthesized silver nanoparticles against biofilm associated enterococcal urinary pathogens

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: March 9, 2022

Abstract Biofilm-formed enterococcal urinary tract clinical isolates (n = 92) were used for studying the antibiofilm activity of cinnamon, ginger, and chemical AgNPs. The average particle sizes AgNPs 8.7, 41.98, 55.7 nm, respectively. results Fourier transform infrared analysis revealed that phytocompounds, such as cinnamaldehyde gingerol, main compounds incorporated in synthesis cinnamon ginger AgNPs, purity crystalline nature have been confirmed by energy dispersive X-ray Diffraction analysis. antimicrobial showed MIC 37.64, 725.7, 61.08 μg/ml, On at sub-MIC values (1/2, 1/4, 1/8 MIC), it was concentration dependent. Therefore, further studies carried out to evaluate a 18 μg/ml. reduced formed biofilm 39.14% 65.32% number adherent cells on catheter surface 42.73% 69.84%, respectively, compared control, while no significant activity. Accordingly, had most potent antibacterial antiadherent against biofilm-associated isolates.

Language: Английский

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An intriguing approach toward antibacterial activity of green synthesized Rutin-templated mesoporous silica nanoparticles decorated with nanosilver

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: April 12, 2023

Abstract In recent years, mesoporous silica nanoparticles (MSNs) have been applied in various biomedicine fields like bioimaging, drug delivery, and antibacterial alternatives. MSNs could be manufactured through green synthetic methods as environmentally friendly sustainable synthesis approaches, to improve physiochemical characteristics for biomedical applications. the present research, we used Rutin (Ru) extract, a biocompatible flavonoid, reducing agent nonsurfactant template of Ag-decorated MSNs. Transmission electron microscopy (TEM), zeta-potential, x-ray powder diffraction (XRD), fourier transform infrared (FTIR) spectroscopy analysis, scanning (SEM), brunauer–emmett–teller (BET) energy-dispersive system (EDS) were evaluate physical characteristics. The antimicrobial properties evaluated against Staphylococcus aureus (S . aureus), Escherichia coli ( E coli), also different types candida. cytotoxicity test was performed by using MTT assay. Based on findings, significant efficacy Ru-Ag-decorated both gram positive negative bacteria fungi detected well acceptable safety low even at lower concentrations. Our results given straightforward cost-effective method fabricating biodegradable applications these domains appear promising.

Language: Английский

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Metal-Based Nanoparticles in Food Packaging and Coating Technologies: A Review

Biomolecules, Journal Year: 2023, Volume and Issue: 13(7), P. 1092 - 1092

Published: July 7, 2023

Food security has continued to be a topic of interest in our world due the increasing demand for food. Many technologies have been adopted enhance food supply and narrow gap. Thus, attempt use nanotechnology improve increase emerged severe shortcomings conventional technologies, which made them insufficient cater continuous products. Hence, nanoparticles identified play major role areas involving production, protection, shelf-life extensions. Specifically, metal-based singled out an important manufacturing materials with outstanding properties, can help different materials. The physicochemical biological properties nanoparticles, such as large surface area antimicrobial suitable adequately useful, not just regular packaging material but functional upon incorporation into biopolymer matrices. These, amongst many other reasons, led their wide synthesis applications, even though methods preparation risk evaluation remain concern. This review, therefore, briefly explores available synthetic methods, roles, packaging. Furthermore, associated limitations, alongside quality safety considerations, these were summarily explored. Although this research continues garner attention, review showed that possess great potential leading if problem migration toxicity effectively modulated.

Language: Английский

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Bioinspired silver nanoparticle-based nanocomposites for effective control of plant pathogens: A review

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 908, P. 168318 - 168318

Published: Nov. 11, 2023

Language: Английский

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Mechanochemical Synthesis of Nanoparticles for Potential Antimicrobial Applications

Materials, Journal Year: 2023, Volume and Issue: 16(4), P. 1460 - 1460

Published: Feb. 9, 2023

There is an increased interest in porous materials due to their unique properties such as high surface area, enhanced catalytic properties, and biological applications. Various solvent-based approaches have been already used synthesize materials. However, the use of large volume solvents, toxicity, time-consuming synthesis make this process less effective, at least terms principles green chemistry. Mechanochemical one effective eco-friendly alternatives conventional synthesis. It adopts efficient mixing reactants using ball milling without or with a very small gives smaller size nanoparticles (NPs) larger facilitates functionalization, which highly beneficial for antimicrobial A variety nanomaterials different applications synthesized by method. This review emphasizes comparison between mechanochemical methods mainly inorganic NPs potential applications, although some metal-organic framework are briefly presented too.

Language: Английский

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Silver Nanoparticles: A Comprehensive Review of Synthesis Methods and Chemical and Physical Properties

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(18), P. 1527 - 1527

Published: Sept. 20, 2024

Recently, silver nanoparticles (NPs) have attracted significant attention for being highly desirable nanomaterials in scientific studies as a result of their extraordinary characteristics. They are widely known effective antibacterial agents that capable targeting wide range pathogens. Their distinct optical characteristics, such localized surface plasmon resonance, enlarge utilization, particularly the fields biosensing and imaging. Also, capacity to control charge modify them using biocompatible substances offers improved durability specific interactions with biological systems. Due exceptional stability minimal chemical reactivity, NPs suitable diverse array applications. These produced through chemical, biological, physical processes, each which has advantages disadvantages. Chemical techniques often encounter issues complicated purification, reactive substances, excessive energy usage. However, eco-friendly approaches exist, even though they require longer processing times. A key factor affecting stability, size distribution, purity is synthesis process selected. This review focuses on how essential it choose appropriate method order optimize characteristics use NPs.

Language: Английский

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