Salivary Biomarkers for Alzheimer’s Disease: A Systematic Review with Meta-Analysis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1168 - 1168

Published: Jan. 18, 2024

Alzheimer’s Disease (AD) is the most common neurodegenerative disease which manifests with progressive cognitive impairment, leading to dementia. Considering noninvasive collection of saliva, we designed systematic review answer question “Are salivary biomarkers reliable for diagnosis Disease?” Following inclusion and exclusion criteria, 30 studies were included in this (according PRISMA statement guidelines). Potential include mainly proteins, metabolites even miRNAs. Based on meta-analysis, AD patients, levels beta-amyloid42 p-tau significantly increased, t-tau lactoferrin decreased at borderline statistical significance. However, according pooled AUC, showed a significant predictive value salivary-based diagnosis. In conclusion, potential markers such as beta-amyloid42, tau can be detected saliva could reliably support early disease.

Language: Английский

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An electrochemical immunosensor based on AgNPs/Nafion-GCE for detection of salivary lactoferrin: Alzheimer’s disease biomarker

Microchemical Journal, Journal Year: 2024, Volume and Issue: 207, P. 112079 - 112079

Published: Nov. 1, 2024

Language: Английский

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Multi-Omics Assessment of Puff Volume-Mediated Salivary Biomarkers of Metal Exposure and Oxidative Injury Associated with Electronic Nicotine Delivery Systems

Environmental Health Perspectives, Journal Year: 2025, Volume and Issue: 133(1)

Published: Jan. 1, 2025

Since their inception, electronic nicotine delivery systems (ENDS) have gained increasing popularity, sparking a vaping epidemic among adolescents in the US and globally. Several ENDS safety concerns emerged as device features formats that contribute to heavy metal exposure toxicity continue evolve outpace regulatory efforts. Our objective was integrate emission profiles with salivary proteome metabolome data characterize factors may influence adverse vaping-mediated health outcomes. A total of 56 participants (38 exclusive users 18 non-ENDS users) were recruited. subset 15 completed puffing topography assessments obtain individual behavior patterns using each participant's device. Inductively coupled plasma mass spectrometry used determine content emissions (12 devices) generated programmable aerosol generation system saliva (15 5 users). Saliva samples from 10 analyzed for proteomic, metabolomic, inflammatory, oxidative stress/damage biomarkers. linear puff volume-dependent increase particle metals observed aerosols users. Elevated levels cytokines, including tumor necrosis factor-alpha (TNFα), interleukin-1 beta (IL-1β), IL-6, alongside damage indicators malondialdehyde (MDA), superoxide dismutase (SOD), 8-hydroxy-2'-deoxyguanosine (8-OHdG). Proteome-metabolome network analysis showed higher risk potentially developing neurological respiratory diseases compared Integrated proteome-metabolome-metallome further demonstrated associated proteomic metabolomic perturbations, notable alterations inflammatory response, immune function, disease-related pathways. significant correlation between metals, stress markers reveals potential role changes DNA inflammation. study demonstrates importance characterizing when examining human implications use. https://doi.org/10.1289/EHP14321.

Language: Английский

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Dietary methionine restriction improves gut microbiota composition and prevents cognitive impairment ind-galactose-induced aging mice

Food & Function, Journal Year: 2022, Volume and Issue: 13(24), P. 12896 - 12914

Published: Jan. 1, 2022

Dietary methionine restriction (MR) has been shown to delay aging and ameliorate age-related cognitive impairments. We hypothesized that changes in the gut microbiota may mediate these effects. To test this hypothesis, ICR mice subcutaneously injected with 150 mg kg-1 day-1D-galactose were fed a normal (0.86% methionine) or an MR (0.17% diet for 2 months. Multiple behavioral experiments performed, composition, metabolite profiles related short-chain fatty acids (SCFAs) feces, indicators redox inflammatory states hippocampus further analyzed. Our results indicated alleviated impairment (including non-spatial memory deficits, working hippocampus-dependent spatial deficits) anxiety-like behavior D-Gal-induced mice. Furthermore, increased abundance of putative SCFA-producing bacteria such as Lachnospiraceae, Turicibacter, Roseburia, Ruminococcaceae_UCG-014, Intestinimonas, Rikenellaceae, Tyzzerella, H2S-producing Desulfovibrio feces. Moreover, reversed normalized levels intestinal SCFAs (acetate, propionate, butyrate) important intermediate metabolites (pyruvate, lactate, malate, fumarate, succinate), abolished aging-induced oxidative stress responses, H2S plasma hippocampus, selectively modulated expression multiple learning- memory-related genes hippocampus. These findings suggest improved composition SCFA production responses which might prevent D-galactose-induced

Language: Английский

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The Interplay between Mitochondrial Dysfunction and Ferroptosis during Ischemia-Associated Central Nervous System Diseases

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(10), P. 1367 - 1367

Published: Sept. 25, 2023

Cerebral ischemia, a leading cause of disability and mortality worldwide, triggers cascade molecular cellular pathologies linked to several central nervous system (CNS) disorders. These disorders primarily encompass ischemic stroke, Alzheimer's disease (AD), Parkinson's (PD), epilepsy, other CNS conditions. Despite substantial progress in understanding treating the underlying pathological processes various neurological diseases, there is still notable absence effective therapeutic approaches aimed specifically at mitigating damage caused by these illnesses. Remarkably, ischemia causes severe cells ischemia-associated diseases. initiates oxygen glucose deprivation, which subsequently promotes mitochondrial dysfunction, including permeability transition pore (MPTP) opening, mitophagy excessive fission, triggering forms cell death such as autophagy, apoptosis, well ferroptosis. Ferroptosis, novel type regulated (RCD), characterized iron-dependent accumulation lethal reactive species (ROS) lipid peroxidation. Mitochondrial dysfunction ferroptosis both play critical roles pathogenic progression In recent years, growing evidence has indicated that interplays with aggravate cerebral injury. However, potential connections between have not yet been clarified. Thus, we analyzed mechanism We also discovered GSH depletion GPX4 inactivation lipoxygenase activation calcium influx following injury, resulting MPTP opening dysfunction. Additionally, electron transport an imbalanced fusion-to-fission ratio can lead ROS iron overload, further contribute occurrence This creates vicious cycle continuously worsens this study, our focus on exploring interplay ferroptosis, may offer new insights into for treatment

Language: Английский

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Current developments and opportunities of pluripotent stem cells-based therapies for salivary gland hypofunction

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 19, 2024

Salivary gland hypofunction (SGH) caused by systemic disease, drugs, aging, and radiotherapy for head neck cancer can cause dry mouth, which increases the risk of disorders such as periodontitis, taste disorders, pain burning sensations in dental caries, dramatically reduces quality life patients. To date, treatment SGH is still aimed at relieving patients’ clinical symptoms improving their life, not able to repair regenerate damaged salivary glands. Pluripotent stem cells (PSCs), including embryonic (ESCs), induced pluripotent (iPSCs), extended (EPSCs), are an emerging source cellular therapies that capable unlimited proliferation differentiation into all three germ layers. In recent years, immunomodulatory tissue regenerative effects PSCs, derived cells, paracrine products these have received increasing attention demonstrated promising therapeutic some preclinical studies targeting SGH. This review outlined etiologies available treatments The existing efficacy potential role summarized, with a focus on PSC-derived stem/progenitor (SGS/PCs) mesenchymal (MSCs). this Review, we provide conceptual outline our current understanding PSCs-based therapy its importance treatment, may inform serve design future studies.

Language: Английский

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The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1590 - 1590

Published: Aug. 16, 2022

Atopic dermatitis (AD) and chronic urticaria (CU) are common skin diseases with an increasing prevalence pathogenesis that not fully understood. Emerging evidence suggests oxidative stress plays a role in AD CU. The aim of the single-center cross-sectional study was to compare markers 21 patients AD, 19 CU patients. products protein oxidation, total antioxidant capacity (TAC), lipid peroxidation were estimated serum. had higher level advanced oxidation lower thiol groups than healthy participants. However, statistically levels AOPP 3-nitrotyrosine subjects. serum TAC decreased significantly There no difference concentration products, Amadori ratio reduced oxidized glutathione, ability albumin binding cobalt between or compared We found moderate positive significant correlation age AD. In CU, negatively correlated age. These results may shed light on etiopathogenesis confirm burden these Furthermore, our could be useful developing new therapeutic methods include using antioxidants dermatological diseases.

Language: Английский

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Metformin mitigates amyloid β1-40-induced cognitive decline via attenuation of oxidative/nitrosative stress and neuroinflammation

Metabolic Brain Disease, Journal Year: 2023, Volume and Issue: 38(4), P. 1127 - 1142

Published: Feb. 1, 2023

Language: Английский

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Antioxidant, Antibacterial Properties of Novel Peptide CP by Enzymatic Hydrolysis of Chromis notata By-Products and Its Efficacy on Atopic Dermatitis

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(1), P. 44 - 44

Published: Jan. 12, 2024

This study investigated the antioxidant, antimicrobial, and anti-atopic dermatitis (AD) effects of a novel peptide (CP) derived from Chromis notata by-product hydrolysate. Alcalase, Flavourzyme, Neutrase, Protamex enzymes were used to hydrolyze C. protein, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging activity was measured. Alcalase hydrolysate exhibited highest ABTS activity, leading selection for further purification. The CHAO-1-I fraction, with isolated purified, resulting in identification CP amino acid sequence Ala-Gln-Val-Met-Lys-Leu-Pro-His-Arg-Met-Gln-His-Ser-Gln-Ser. demonstrated antimicrobial against Staphylococcus aureus, inhibiting its growth. In 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin model mice, significantly alleviated lesions, reduced epidermal dermal thickness, inhibited mast cell infiltration. Moreover, suppressed elevated levels interleukin-6 (IL-6) plasma DNCB-induced mice. These findings highlight potential as therapeutic agent AD suggest application this fish processing industry.

Language: Английский

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Atrophy and Inflammatory Changes in Salivary Glands Induced by Oxidative Stress after Exposure to Drugs and Other Chemical Substances: A Systematic Review

Medicina, Journal Year: 2023, Volume and Issue: 59(9), P. 1692 - 1692

Published: Sept. 21, 2023

Background and Objectives: Oxidative stress is involved in the alterations at level of salivary glands, being cause oral pathologies like xerostomia, periodontitis, gingivitis, leucoplakia, cancer. It known that antioxidants can reverse changes induced by drugs or other chemicals some organs, but question whether these substances reduce revert effects oxidative gland level. Our aim was to find histopathological data glands supporting hypothesis reversal stress-induced after treatment with antioxidant effect. Materials Methods: A systematic search conducted PubMed, Science Direct, Springer databases, including research articles on histological aspects biomarkers glands. Results: Out 1756 articles, 25 were selected tissue homogenate used for biochemical analysis antioxidative markers, along routine hematoxylin eosin (HE) immunohistochemical diagnosis. Drugs (antineoplastic drugs, antibiotics, analgesics), alcohol, heavy metals, fluoride stress, resulting morphological different tissues, There are many only a few evaluated regarding animal studies, such as hesperidin selenium, which damage cyclophosphamide; 10-dehydrogingerdione (10-DHGD), compound extracted from ginger, has protective effect against apoptosis tramadol; glycyrrhizic acid, may repair injuries incurred administration sodium nitrite. Conclusions: Substances hesperidin, 10-dehydrogingerdione, acid proven restorative exposure chemical substances; however, demonstrating their similar human challenging.

Language: Английский

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