Breathing coordinates cortico-hippocampal dynamics in mice during offline states

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Jan. 24, 2022

Network dynamics have been proposed as a mechanistic substrate for the information transfer across cortical and hippocampal circuits. However, little is known about mechanisms that synchronize coordinate these processes widespread brain regions during offline states. Here we address hypothesis breathing acts an oscillatory pacemaker, persistently coupling distributed circuit dynamics. Using large-scale recordings from number of subcortical in behaving mice, uncover presence intracerebral respiratory corollary discharge, modulates neural activity During states, modulation underlies sharp-wave ripples DOWN/UP state transitions, which mediates systems memory consolidation. These results highlight breathing, perennial rhythm, scaffold functional coordination limbic supports segregation integration flow neuronal networks

Language: Английский

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Temporal Relations between Cortical Network Oscillations and Breathing Frequency during REM Sleep

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(24), P. 5229 - 5242

Published: May 7, 2021

Nasal breathing generates a rhythmic signal which entrains cortical network oscillations in widespread brain regions on cycle-to-cycle time scale. It is unknown, however, how respiration and neuronal activity interact larger scale: are frequency typical oscillation patterns correlated? Is there any directionality or temporal relationship? To address these questions, we recorded field potentials from the posterior parietal cortex of mice together with during REM sleep. In this state, exhibits prominent θ γ while behavioral minimal, reducing confounding signals. We found that instantaneous strongly correlates amplitude both oscillations. Cross-correlograms Granger causality revealed specific directionalities for different rhythms: changes precede Granger-cause frequency, suggesting control by functional state brain. On other hand, causes influenced peripheral reafference signal. These findings show temporally relate to activity. hypothesize such relations mediated common central drive likely be located brainstem.

Language: Английский

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Respiration-Driven Brain Oscillations in Emotional Cognition

Frontiers in Neural Circuits, Journal Year: 2021, Volume and Issue: 15

Published: Oct. 27, 2021

Respiration paces brain oscillations and the firing of individual neurons, revealing a profound impact rhythmic breathing on activity. Intriguingly, respiration-driven entrainment neural activity occurs in variety cortical areas, including those involved higher cognitive functions such as associative neocortical regions hippocampus. Here we review recent findings respiration-entrained with particular focus emotional cognition. We summarize studies from different areas behavior fear, despair, motivation, compile activities across species. Furthermore, discuss proposed cellular network mechanisms by which circuits are entrained respiration. The emerging synthesis large body literature suggests that respiration function is widespread highly relevant for distinct functions. These intricate links between processes call mechanistic role timing signal

Language: Английский

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Delta-range coupling between prefrontal cortex and hippocampus supported by respiratory rhythmic input from the olfactory bulb in freely behaving rats

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: April 14, 2021

Abstract Respiratory rhythm (RR) during sniffing is known to couple with hippocampal theta rhythm. However, outside of the short bouts, a more stable ~ 2 Hz RR was recently shown rhythmically modulate non-olfactory cognitive processes, as well. The underlying coupling wide-spread forebrain activity confirmed using advanced techniques, creating solid premise for investigating how higher networks use this mechanism in their communication. Here we show essential differences way prefrontal cortex (PFC) and hippocampus (HC) process signal from olfactory bulb (OB) that may support dynamic, flexible PFC-HC utilizing input. We used inter-regional coherences correlations rats, breathing at low rate (~ Hz), bouts. found strong OB-PFC coherence wake states, contrasting OB-HC which but highly variable. Importantly, variability establishing synchrony RR, whereas variations RRO OB PFC had no significant effect. findings help understand rhythmic modulation processes by on-going regular respiration, reported rodents well humans. These mechanisms be impaired when nasal limited or OB-pathology, including malfunctions epithelium due infections, such Covid-19.

Language: Английский

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Respiratory sinus arrhythmia (RSA), vagal tone and biobehavioral integration: Beyond parasympathetic function

Biological Psychology, Journal Year: 2023, Volume and Issue: 186, P. 108739 - 108739

Published: Dec. 25, 2023

Linchpin to the entire area of psychophysiological research and discussion vagus is respiratory cardiovascular phenomenon known as sinus arrhythmia (RSA; often synonymous with high-frequency heart-rate variability when it specifically linked frequency), i.e. rhythmic fluctuations in heart rate synchronized inspiration expiration. This article aims 1) clarify concepts, terms measures commonly employed during last half century scientific literature, which relate vagal function psychological processes general aspects health; 2) expand upon an earlier theoretical model, emphasizing importance RSA well beyond current focus parasympathetic mechanisms. A close examination its relations may dispel certain held beliefs about associations between functioning, nervous system (for nerve plays a major role), offer fresh perspectives likely functions adaptive significance RSA, RSA's relationship control. neither invariably reliable index cardiac tone nor central outflow heart. The model here presented posits that represents evolutionarily entrenched, significantly contributes meeting continuously changing metabolic, energy behavioral demands.

Language: Английский

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Circuit formation and sensory perception in the mouse olfactory system

Frontiers in Neural Circuits, Journal Year: 2024, Volume and Issue: 18

Published: Feb. 16, 2024

In the mouse olfactory system, odor information is converted to a topographic map of activated glomeruli in bulb (OB). Although arrangement genetically determined, glomerular structure plastic and can be modified by environmental stimuli. If pups are exposed particular odorant, responding become larger recruiting dendrites connecting projection neurons interneurons. This imprinting not only increases sensitivity odor, but also imposes positive quality on imprinted memory. External represented as an OB transmitted cortex (OC) amygdala for decision making elicit emotional behavioral outputs using two distinct neural pathways, innate learned. Innate circuits start work right after birth, whereas learned functional later on. this paper, recent progress will summarized study circuit formation perception mice. We propose new hypotheses timing gating activity relation respiration cycle.

Language: Английский

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The timing of sleep spindles is modulated by the respiratory cycle in humans

Clinical Neurophysiology, Journal Year: 2024, Volume and Issue: 166, P. 252 - 261

Published: July 9, 2024

Coupling of sleep spindles with cortical slow waves and hippocampus sharp-waves ripples is crucial for sleep-related memory consolidation. Recent literature evidenced that nasal respiration modulates neural activity in large-scale brain networks. In rodents, this respiratory drive strongly varies according to vigilance states. Whether oscillations are also respiration-modulated humans remains open. work, we investigated the influence breathing on during non-rapid-eye-movement humans. Full night polysomnography twenty healthy participants were analysed. Spindles automatically detected N2 N3 stages. Spindle-related sigma power as well spindle wave events analysed phase. We found a significant coupling between both fast cycle, enhanced occurrence probability middle part expiration A different was observed negative peaks which rather distributed around two phase transitions. Our findings suggest cycle influences dynamics sleep. This may enable synchronize other facilitate information transfer

Language: Английский

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Behavioral State-Dependent Modulation of Prefrontal Cortex Activity by Respiration

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(26), P. 4795 - 4807

Published: June 5, 2023

Respiration-rhythmic oscillations in the local field potential emerge mPFC, a cortical region with key role regulation of cognitive and emotional behavior. Respiration-driven rhythms coordinate activity by entraining fast γ as well single-unit discharges. To what extent respiration entrainment differently engages mPFC network behavioral state-dependent manner, however, is not known. Here, we compared mouse PFC spiking (23 male 2 female mice) across distinct states: during awake immobility home cage (HC), passive coping response to inescapable stress under tail suspension (TS), reward consumption (Rew). emerged all three states. However, prefrontal were more strongly entrained HC than TS or Rew. Moreover, neuronal spikes putative pyramidal cells interneurons showed significant phase-coupling throughout behaviors characteristic phase preferences depending on state. Finally, while dominated deep layers Rew conditions, resulted recruitment superficial layer neurons respiration. These results jointly suggest that dynamically entrains state.SIGNIFICANCE STATEMENT The through its extensive connections (e.g., amygdala, striatum, serotoninergic dopaminergic nuclei), flexibly regulates behaviors. Impairment functions can lead disease states, such depression, addiction, anxiety disorders. Deciphering complex defined states thus an essential challenge. investigated slow oscillation has recently attracted rising interest, rhythm, modulating We show rhythm cell type- behavior-dependent manner. provide first insight into modulation patterns rhythmic breathing.

Language: Английский

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Confounding effects of heart rate, breathing rate, and frontal fNIRS on interoception

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Nov. 30, 2022

Recent studies have established that cardiac and respiratory phases can modulate perception related neural dynamics. While heart rate sinus arrhythmia possibly affect interoception biomarkers, such as heartbeat-evoked potentials, the relative changes in cardiorespiratory dynamics interoceptive processes not yet been investigated. In this study, we investigated variation breathing rates, well higher functional including correlation frontal hemodynamics measured with fNIRS, during a heartbeat counting task. To further investigate physiology linked to vagal activity caused by specific performed task together controlled The results demonstrate focusing on heartbeats decreases rates comparison, which may be part of physiological mechanisms "listening" heart, focus attention, self-awareness. Focusing was also observed increase connectivity, supporting role structures monitoring visceral inputs. However, is affected both tasks. Based these results, concluded variations are confounding factors assessment abilities fluctuations should considered mode covariate measurement processes.

Language: Английский

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Respiratory influence on brain dynamics: the preponderant role of the nasal pathway and deep slow regime

Pflügers Archiv - European Journal of Physiology, Journal Year: 2022, Volume and Issue: 475(1), P. 23 - 35

Published: June 30, 2022

Language: Английский

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