Exploring the Use of Cold Atmospheric Plasma to Overcome Drug Resistance in Cancer

Biomedicines, Journal Year: 2023, Volume and Issue: 11(1), P. 208 - 208

Published: Jan. 14, 2023

Drug resistance is a major problem in cancer treatment, as it limits the effectiveness of pharmacological agents and can lead to disease progression. Cold atmospheric plasma (CAP) technology that uses ionized gas (plasma) generate reactive oxygen nitrogen species (RONS) kill cells. CAP novel approach for overcoming drug cancer. In recent years, there has been growing interest using enhance chemotherapy drugs. this review, we discuss mechanisms behind phenomenon explore its potential applications treatment. Going through existing literature on cancer, highlight challenges opportunities further research field. Our review suggests could be promising option warrants investigation.

Language: Английский

---

Effects of cold atmospheric-pressure plasma in combination with doxorubicin drug against breast cancer cells in vitro and in vivo

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 209, P. 202 - 210

Published: Oct. 27, 2023

Language: Английский

---

Recent Advances in Liposomes Efficacy as a Drug Delivery Platform for Melanoma Treatment

Russian Journal of Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 51(1), P. 93 - 116

Published: Feb. 1, 2025

Language: Английский

---

Synergistic effect of cold gas plasma and experimental drug exposure exhibits skin cancer toxicity in vitro and in vivo

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: unknown

Published: June 1, 2023

Skin cancer is often fatal, which motivates new therapy avenues. Recent advances in treatment are indicative of the importance combination treatments oncology. Previous studies have identified small molecule-based therapies and redox-based technologies, including photodynamic or medical gas plasma, as promising candidates to target skin cancer. We aimed identify effective combinations experimental molecules with cold plasma for dermato-oncology. Promising drug were after screening an in-house 155-compound library using 3D spheroids high content imaging. Combination effects selected drugs investigated respect oxidative stress, invasion, viability. Drugs that had combined well further vascularized tumor organoids ovo a xenograft mouse melanoma model vivo. The two chromone derivatives Sm837 IS112 enhanced plasma-induced histone 2A.X phosphorylation, reduced proliferation cell grown confirmed principal anti-cancer effect drugs. While one compounds exerted severe toxicity vivo, other (Sm837) resulted significant synergistic anti-tumor at good tolerability. Principal component analysis protein phosphorylation profiles profound contrast monotherapies. novel compound that, topical represents approach

Language: Английский

---

Cold atmospheric plasma (CAP): a revolutionary approach in dermatology and skincare

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Oct. 5, 2024

Language: Английский

---

Development of linagliptin-loaded liposomes using aspartic acid conjugate for bone-targeted delivery to combat osteoporosis

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Feb. 13, 2025

Osteoporosis is a common metabolic bone disorder that requires new treatment strategies. Linagliptin, dipeptidyl peptidase-4 (DPP-4) inhibitor proven osteogenic agent in diabetes-linked loss. However, poor solubility, low oral bioavailability, and inadequate bone-targeting limit its use osteoporosis. We have successfully developed the bone-targeted liposomes of linagliptin using an aspartic acid conjugate i.e., poly (aspartic acid-co-lactide)-1,2-dipalmitoyl-sn-glycero-3-phospho ethanolamine (PAL-DPPE), which was prior synthesized identified FTIR & NMR. Liposomes were evaluated for particle size, encapsulation efficacy, drug loading, release study addition to vitro hydroxyapatite binding ability. To determine anti-osteoporosis effect liposomes, vivo testing performed glucocorticoid-induced osteoporosis model mice. Bone targeted having size 281.7 nm affinity 89%, significantly improved architecture parameters mineral density micro-computed tomography analysis. Further, these positively modulated sclerostin, morphogenetic protein-2, receptor activator nuclear factor kappa beta/osteoprotegerin ratio showed favourable changes other turnover biomarkers. The findings demonstrate (PAL-DPPE) based hold promise Moreover, possible mechanistic pathways involved here Wnt AMPK pathway.

Language: Английский

---

Synergistic effects of cold atmospheric plasma and doxorubicin on melanoma: A systematic review and meta-analysis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 6, 2025

Melanoma is responsible for the majority of skin cancer deaths, but there are ways to combat this deadly disease. One method using anti-neoplastic agents, such as Doxorubicin (DOX). Unfortunately, DOX can be toxic and may lead drug resistance. However, researchers excited about potential Cold Atmospheric Plasma (CAP) treatment cells overcome resistance selectively. To better understand effectiveness combination CAP on melanoma cell viability, cytotoxicity, death, we conducted a comprehensive evaluation meta-analysis in study. 41 studies out 121 met our inclusion criteria. The pooled analysis found that had significant effect viability (ES = 6.75, 95% CI 1.65 11.85, I2 71%) cytotoxicity 11.71, 3.69 19.73, 56%). however, no statistically association was between death with treatment. Our have confirmed combined has synergistic reducing increasing cells. These results assist selecting more effective methods address melanoma.

Language: Английский

---

Moxifloxacin Liposomes: Effect of Liposome Preparation Method on Physicochemical Properties and Antimicrobial Activity against Staphylococcus epidermidis

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(2), P. 370 - 370

Published: Feb. 7, 2022

The aim of this study was the development optimal sustained-release moxifloxacin (MOX)-loaded liposomes as intraocular therapeutics endophthalmitis. Two methods were compared for preparation MOX liposomes; dehydration-rehydration (DRV) method and active loading (AL). Numerous lipid-membrane compositions studied to determine potential effect on retention in liposomes. phospholipid contents measured by HPLC a colorimetric assay phospholipids, respectively. Vesicle size distribution surface charge DLS, morphology evaluated cryo-TEM. AL conferred with higher encapsulation DRV all lipid used. Cryo-TEM showed that both liposome types had round vesicular structure around 100-150 nm, while granular texture evident entrapped aqueous compartments most liposomes, but substantially less X-ray diffraction analysis demonstrated slight crystallinity especially ones highest encapsulation. retained significantly longer time periods DRVs. Lipid composition did not affect release from altered drug loading/release Interestingly, antimicrobial towards S. epidermidis growth biofilm susceptibility corresponding indicating importance their activity. In conclusion, method/type determines rate modulates potential, finding deserves further vitro vivo exploitation.

Language: Английский

---

Cold atmospheric plasma enhances doxorubicin selectivity in metastasic bone cancer

Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 189, P. 32 - 41

Published: July 14, 2022

High-dose systemic chemotherapy constitutes a main strategy in the management of bone metastases, employing drugs like doxorubicin (DOX), related with severe side effects. To solve this issue, Cold Atmospheric Plasmas (CAP) have been proposed as potential non-invasive anti-cancer agents capable improving efficacy traditional drugs. Here, we investigate cytotoxic effects Plasma Conditioned Medium (PCM) combination DOX prostate cancer cells from metastases (PC-3) well non-malignant bone-cells. PCM was able to enhance both monolayer and 3D bioengineered model mimicking matrix. The combined treatment + resulted profound downregulation redox defenses (CAT1, SOD2, GPX1) drug resistance genes (MRP1, MDR1, BCRP1), resulting an enhanced uptake coupled overload intracellular ROS. Besides, improved interfering on migratory clonogenic PC-3 cells. Importantly, were unaffected by DOX. Overall, these new findings may represent therapeutic approach for metastatic future.

Language: Английский

---

Medical Gas Plasma Technology Combines with Antimelanoma Therapies and Promotes Immune‐Checkpoint Therapy Responses

Advanced Science, Journal Year: 2023, Volume and Issue: 10(28)

Published: Aug. 4, 2023

Abstract Strategies to improve activity and selectivity are major goals in oncological drug development. Medical gas plasma therapy has been subject intense research dermatooncology recently. Based on partial ionization, this approach is exceptional generating a variety of reactive oxygen species simultaneously that can be applied locally at the tumor side. It hypothesized combined treatment potentiate responses melanoma. Using jet approved as medical device Europe, systematic screening 46 mitochondria‐targeted drugs identifies five agents synergizing vitro vivo. Increased intratumoral leucocyte infiltration points immunomodulatory aspects treatment, motivating investigate immune checkpoint blockade combination with plasma. Tumor growth monitored based bioluminescent imaging, single‐cell suspensions retrieved from each characterize tumor‐infiltrating leucocytes using multicolor flow cytometry. Gene expression profiling done validated NanoString panel targeting 770 genes specifically designed for immuno‐oncological research. Cell type abundancies characterized bulk RNA samples CIBERSORT computational framework. Collectively, results indicate local application technology synergizes anti‐PD1 treating

Language: Английский

---