Chemical Variability and Pharmacological Potential of Propolis as a Source for the Development of New Pharmaceutical Products

Molecules, Journal Year: 2022, Volume and Issue: 27(5), P. 1600 - 1600

Published: Feb. 28, 2022

This review aims to analyze propolis as a potential raw material for the development and manufacture of new health-promoting products. Many scientific publications were retrieved from Scopus, PubMed, Google Scholar databases via searching word "propolis". The different extraction procedures, key biologically active compounds, biological properties, therapeutic analyzed. It was concluded that possesses variety properties because very complex chemical composition mainly depends on plant species visited by bees bees. Numerous studies found versatile pharmacological activities propolis: antimicrobial, antifungal, antiviral, antioxidant, anticancer, anti-inflammatory, immunomodulatory, etc. In this review, are presented point view origin standardization purpose pharmaceutical products its base. revealed some types propolis, especially European contain flavonoids phenolic acids, which could be markers quality evaluation preparations. One more focus paper overview microorganisms' sensitivity further antimicrobial antioxidant treatment various infectious diseases with an emphasis illnesses oral cavity. established activity is quite significant, Gram-negative bacteria lipophilic viruses. present study also interest industry appropriate design standardized preparations such mouthwashes, toothpastes, drops, sprays, creams, ointments, suppositories, tablets, capsules, Moreover, regarded source isolation substances. Furthermore, can facilitate partially overcoming problem preparations, principal obstacle broader use in industry. Finally, area food nutritionally well-balanced results indicate deserves better studied promising effects connection locality collection, vegetation, methods, standardization.

Language: Английский

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Polyphenols: Secondary Metabolites with a Biological Impression

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2550 - 2550

Published: Aug. 3, 2024

Polyphenols are natural compounds which plant-based bioactive molecules, and have been the subject of growing interest in recent years. Characterized by multiple varieties, polyphenols mostly found fruits vegetables. Currently, many diseases waiting for a cure or solution to reduce their symptoms. However, drug other chemical strategies limitations using treatment agent still detection tool diseases, thus researchers need investigate preventive improving treatment. Therefore, it is elucidate polyphenols, bioactivity effects, supplementation, consumption. The disadvantage that they limited bioavailability, although beneficial outcomes with roles. In this context, several different developed improve particularly liposomal nanoparticles. As nutrition one most important factors health, inclusion molecules daily diet significant continues be enthusiastically researched. Nutrition, individuals all ages, key polyphenols.

Language: Английский

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Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing

Evidence-based Complementary and Alternative Medicine, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 15

Published: July 21, 2022

Propolis is a kind of reduct collected by bees from various plant sources. Because propolis mixture, it has variety biological activities, excellent anti-inflammatory and bactericidal effects. Especially in the treatment infectious wounds, acute burns, scalds promoting wound healing, more scientists began to apply research field healing. The standard preparation combined with other compound components safer less toxic effect trauma. In order effectively use products treatment. This paper reviews mechanism on different types as well synergistic compounds, provide ideas for further exploration activity pharmacological function future, its in-depth development It will also theoretical reference utilization propolis.

Language: Английский

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Bioactive Phytochemical Composition of Grape Pomace Resulted from Different White and Red Grape Cultivars

Separations, Journal Year: 2022, Volume and Issue: 9(12), P. 395 - 395

Published: Nov. 28, 2022

Grapes are rich in phenolic compounds, being important for human health with anti-inflammatory, antiatherosclerotic, antimutagenic, anticarcinogenic, antibacterial, antiviral, and antimicrobial activity. The winemaking of the grapes generates significant amounts waste. These wastes contain bioactive compounds their biomass that can be used as a source food improvement or nutrition supplementation. This study looks at content polyphenolic profile, antioxidant activity different white red grape pomaces. investigation characteristics (total polyphenols, total flavonoids, catechins, tannins, activity) was carried out by UV-Vis spectrophotometric methods, while individual composition investigated target screening UHPLC-HRMS/MS analysis. Principal components (PCA) heat maps analysis allows discrimination between pomace resulted from cultivars (Muscat Ottonel Tamaioasa Romaneasca) pomaces (Cabernet Sauvignon, Merlot, Feteasca Neagra, Burgund Mare, Pinot Nore), identification specific each type.

Language: Английский

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Exploring the Functional Properties of Propolis, Geopropolis, and Cerumen, with a Special Emphasis on Their Antimicrobial Effects

Foods, Journal Year: 2023, Volume and Issue: 12(21), P. 3909 - 3909

Published: Oct. 25, 2023

Bee propolis has been touted as a natural antimicrobial agent with the potential to replace antibiotics. Numerous reports and reviews have highlighted functionalities applications of compound. Despite much clamor for downstream application propolis, there remain many grounds cover, especially in upstream production, factors affecting quality propolis. Moreover, geopropolis cerumen, akin hold promise diverse human applications, yet their benefits intricate manufacturing processes subjects intensive research. Specialized cement bees are pivotal gathering transporting plant resins from suitable sources nests. Contrary common belief, these directly applied within hive, smoothed out by bees, blended beeswax trace components create raw Beekeepers subsequently harvest perform extraction form final extract that is sold on market. As result production process, intrinsic extrinsic factors, such botanical origins, bee species, direct impact extract. Towards end this paper, section dedicated highlighting potency

Language: Английский

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Exploring the corrosion-inhibitory properties of propolis extract via density functional theory and data science approaches

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136286 - 136286

Published: Feb. 1, 2025

Language: Английский

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Curcumin-infused nanostructured lipid carriers: a promising strategy for enhancing skin regeneration and combating microbial infection

BMC Veterinary Research, Journal Year: 2023, Volume and Issue: 19(1)

Published: Oct. 16, 2023

Curcumin is a biomolecule that can be extracted from the Curcuma longa has been shown to have potential aid skin wound healing. It studied for its anti-inflammatory and antioxidant properties, which may help reduce swelling promote tissue repair. However, curcumin low solubility in water, limit absorption bioavailability. Encapsulating it lipid nanoparticles increase absorption, leading improved bioavailability.Curcumin-loaded nanostructure nanocarriers (CURC-NLCs) were prepared characterized. Also, phenolic, flavonoid contents, antimicrobial efficacy against gram-positive gram-negative bacteria investigated. Furthermore, vivo rabbit animal model was used test regenerative capacity wound-healing efficiency.The CURC-NLCs significantly increased content of phenolic compounds compared curcumin, resulting dramatic activity. also showed potent inhibitory effect on Gram-positive, Gram-negative, fungi, two times higher than curcumin. fasten healing full-thickness injuries as resulted 1.15- 1.9-fold closure at first week injury control, respectively (p < 0.0001).These results suggest an excellent regeneration, could attributed broad-spectrum effect.

Language: Английский

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Spectrum–Effect Relationships as an Effective Approach for Quality Control of Natural Products: A Review

Molecules, Journal Year: 2023, Volume and Issue: 28(20), P. 7011 - 7011

Published: Oct. 10, 2023

As natural products with biological activity, the quality of traditional Chinese medicines (TCM) is key to their clinical application. Fingerprints based on types and contents chemical components in TCM are an internationally recognized evaluation method but ignore correlation between efficacy. Through chemometric methods, fingerprints represented by were correlated its pharmacodynamic activity results obtain spectrum–effect relationships TCM, which can reveal information related solve limitations segmentation research TCM. In 20th anniversary proposed relationships, this paper reviews progress field including establishment fingerprints, methods practical applications Furthermore, new strategy recent years was also discussed, application prospects technology discussed.

Language: Английский

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Discrimination of Olive Oil and Extra-Virgin Olive Oil from Other Vegetable Oils by Targeted and Untargeted HRMS Profiling of Phenolic and Triterpenic Compounds Combined with Chemometrics

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5292 - 5292

Published: March 10, 2023

Extra-virgin olive oil (EVOO) and virgin (VOO) are valuable natural products of great economic interest for their producing countries, therefore, it is necessary to establish methods capable proving the authenticity these oils on market. This work presents a methodology discrimination extra-virgin from other vegetable based targeted untargeted high-resolution mass spectrometry (HRMS) profiling phenolic triterpenic compounds coupled with multivariate statistical analysis data. Some (cinnamic acid, coumaric acids, apigenin, pinocembrin, hydroxytyrosol maslinic acid), secoiridoids (elenolic ligstroside oleocanthal) lignans (pinoresinol hydroxy acetoxy derivatives) could be biomarkers, whereby quantified in higher amounts EVOO compared oils. The principal component (PCA) performed samples confirmed that cinnamic acid considered as tracers authentication. heat map profiles HRMS data indicate clear proposed extended authentication classification EVOOs depending variety, geographical origin, or adulteration practices.

Language: Английский

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Baicalein glycymicelle ophthalmic solution: Preparation, in vitro antimicrobial activities, and antimicrobial mechanism evaluations

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 654, P. 123964 - 123964

Published: March 1, 2024

Language: Английский

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