A comprehensive review on graphene oxide-based nanocarriers: Synthesis, functionalization and biomedical applications

FlatChem, Journal Year: 2023, Volume and Issue: 38, P. 100484 - 100484

Published: Feb. 13, 2023

Language: Английский

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Graphene oxide nanoarchitectures in cancer biology: Nano-modulators of autophagy and apoptosis

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 503 - 522

Published: Jan. 20, 2023

Language: Английский

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pH-sensitive ameliorated quercetin delivery using graphene oxide nanocarriers coated with potential anticancer gelatin-polyvinylpyrrolidone nanoemulsion with bitter almond oil

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 82, P. 104339 - 104339

Published: March 10, 2023

The rapid rise of cancer worldwide demonstrates the importance treatment strategies. In addition to reduce side effects conventional treatments, targeted drug delivery systems increase performance and effectiveness. this research, nanocarriers comprising gelatin (G)-polyvinylpyrrolidone (PVP) coated graphene oxide (GO) were prepared for first time. nanocarries loaded with quercetin (QC) a dual nanoemulsion water/oil/water bitter almond oil was developed as membrane around nanocomposite control further release. XRD, FTIR, FESEM, DLS analysis confirmed success synthesis loading. resulting pH-sensitive system showed an 87.5% encapsulation efficiency 45% loading, which are among highest values reported up date. zeta potential nanocomposites about −40 mV, indicating good stability. release kinetics followed Higuchi model, presence resulted in better entrapping efficiency, controlled long-term MTT assay flow cytometry methods revealed rate cell death 53.14%, 36.51% apoptotic phase. Taking into account results obtained herein, PVP-G-GO-QC can be considered new promising treatment.

Language: Английский

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Roadmap to 2D Graphene Nanomaterials-Based Biosensors for Early Cancer Detection

Plasmonics, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Language: Английский

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Reshaping the immune microenvironment and reversing immunosenescence by natural products: prospects for immunotherapy in gastric cancer

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 110, P. 1 - 16

Published: Feb. 8, 2025

Language: Английский

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Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(15), P. 2672 - 2672

Published: Aug. 4, 2022

Cancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder success of different cancer therapeutics. The traditional therapeutic approach has been proven insufficient and lacking in suppression tumor growth. simultaneous delivery small-molecule chemotherapeutic drugs genes improves effectiveness each treatment, thus optimizing efficacy improving synergistic effects. Nanomedicines integrating inorganic, lipid, polymeric-based nanoparticles designed to regulate spatiotemporal release encapsulated drugs. Multidrug-loaded nanocarriers are a potential strategy fight incorporation co-delivery systems as feasible treatment method projected benefits limited undesirable Moreover, development for maximum impact necessitates better knowledge appropriate agent ratio well inherent heterogeneity cells. Co-delivery can simplify clinical processes increase patient quality life, even though such more difficult prepare than single drug systems. This review highlights progress attained design nano carrier-based discusses limitations, challenges, future perspectives fabrication

Language: Английский

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Curcumin delivery and co-delivery based on nanomaterials as an effective approach for cancer therapy

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 78, P. 103982 - 103982

Published: Nov. 12, 2022

Language: Английский

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Bioprinting of self-healing materials and nanostructures for biomedical applications: Recent advances and progresses on fabrication and characterization techniques

Bioprinting, Journal Year: 2024, Volume and Issue: 38, P. e00335 - e00335

Published: Feb. 1, 2024

Language: Английский

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Anticancer and Antibacterial Properties of Curcumin-Loaded Mannosylated Solid Lipid Nanoparticles for the Treatment of Lung Diseases

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(4), P. 2175 - 2185

Published: March 13, 2024

Lung cancer and Mycobacterium avium complex infection are lung diseases associated with high incidence mortality rates. Most conventional anticancer drugs antibiotics have certain limitations, including drug resistance rates adverse effects. Herein, we aimed to synthesize mannose surface-modified solid lipid nanoparticles (SLNs) loaded curcumin (Man-CUR SLN) for the effective treatment of disease. The synthesized Man-CUR SLNs were analyzed using various instrumental techniques structural physicochemical characterization. Loading into improved encapsulation efficiency release capacity, as demonstrated by high-performance liquid chromatography analysis. Furthermore, characterized effect A549 cell line. Cells treated SLN exhibited an increased cellular uptake cytotoxicity. Moreover, free CUR could more effectively reduce migration than SLNs. Similarly, elicited a stronger apoptosis-inducing that SLNs, reverse transcription-quantitative PCR Finally, examined antibacterial effects against intracellulare (M.i.) M.i.-infected macrophages, revealing exerted strongest effect. Collectively, these findings indicate mannose-receptor-targeted delivery be in treating diseases. Accordingly, this system can used target variety cancers immune cells.

Language: Английский

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A biocompatible drug controlled release system based on β-cyclodextrin crosslinked magnetic lactose/ZIF-8 metal-organic frameworks for cancer treatment

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 703, P. 135227 - 135227

Published: Aug. 30, 2024

Language: Английский

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